Trade-offs in human observer performance, image quality metrics, and patient dose

缺乏一个连贯的，以证据为基础的方法来确定“正确的”CT成像协议解释了一个 在很大程度上，在临床CT扫描中观察到的剂量和技术的相当大的变化， 最近受伤的病人接受CT脑成像。一个全面的，高效的，可翻译的 需要一种方法将CT剂量驱动到最低水平，以保持可接受的诊断准确性， 同时跟上不断变化的技术。我们的长期目标是开发和验证 定量方法，可以定量确定，对于特定的诊断任务，CT协议，提供 在最低的患者剂量下达到所需的诊断准确性。 本计画的目的是要在电脑断层影像品质与病人辐射剂量之间取得平衡 通过调查，超越当前的简单模型（例如标准差和CTDIvol）， 基于任务的图像质量指标、观察者表现、患者体型和患者 次给药结束该项目是以前的第四个项目，在一个POL提案题为定量系统 开发剂量优化的CT成像方案（参见P01 EB 014221 -01）。

The lack of a coherent, evidence-based approach for determining the "right" CT imaging protocol explains to a large degree the considerable variation in doses and techniques observed in clinical CT scanning and the recent injuries to patients undergoing CT brain imaging. A comprehensive, time-efficient, and translatable approach is needed to drive CT doses to the lowest levels that maintain acceptable diagnostic accuracy and to do so while keeping up with ever-changing technology. Our long term objective is to develop and validate quantitative methodsthat can quantitatively determine, for a specific diagnostic task, CT protocols that deliver the needed diagnostic accuracy at the lowest patient dose. The obiective of this project is to determine the tradeoffs between CT image quality and patient radiation dose in a way that moves beyond current simple models (e.g. standard deviation and CTDIvol) by investigating the relationships between task-based metrics of image quality, observer performance, patient size, and patient dose. This project was previously the 4th project in a POl proposal entitled Quantitative systematic development of dose-optimized CT imaging protocols {^ POl EB014221-01).