VirtualDose Software for Diagnostic CT Doses to Adults and Children

用于成人和儿童诊断 CT 剂量的 VirtualDose 软件

• 批准号: 8261876
• 负责人: Xie George Xu
• 金额: $ 41.32万
• 依托单位: VIRTUAL PHANTOMS, INC.
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2014-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8261876
• 关键词: 10 year old; 15 year old; 5 year old; Accounting; Adopted; Adult; Age; Algorithms; American; American College of Radiology; Awareness; Body Image; Body Size; Cancer Center; Chest; Child; Childhood; Clinical; Clinical Protocols; Collimator; Communities; Comparative Study; Computer software; Computing Methodologies; Data Reporting; Databases; Development; Diagnostic; Diagnostic Imaging; Discipline of Nuclear Medicine; Dose; Exposure to; Family; Female; Filtration; Florida; Funding; Future; Goals; Heating; Human body; Image; Incidence; Individual; Institutes; Knowledge; Manufacturer Name; Marketing; Measurable; Measurement; Medical; Medical Imaging; Medicine; Methods; Modality; Modeling; New York; Obesity; Organ; Organ Model; Patients; Phase; Photons; Physics; Population; Pregnant Women; Procedures; Protocols documentation; Radiation; Radiation Protection; Radiation therapy; Radiation-Induced Cancer; Radiology Specialty; Recommendation; Registries; Reporting; Research; Research Activity; Research Personnel; Rest; Risk; Roentgen Rays; Role; Scanning; Shapes; Small Business Technology Transfer Research; Societies; Software Design; Software Engineering; Surveys; System; Technology; Technology Transfer; Three-Dimensional Image; Time; Tissues; Tomography, Computed, Scanners; Tube; United States National Institutes of Health; Universities; X-Ray Computed Tomography; base; design; detector; graphical user interface; imaging modality; improved; ionization; male; meetings; member; model design; patient population; pregnant; programs; public health relevance; radiologist; risk selection; sex; simulation; software systems; success; tool; trend; user-friendly; virtual

DESCRIPTION (provided by applicant): This project aims to develop a commercial software product, VirtualDoseTM, for calculating and analyzing patient radiation doses from x-ray computed tomography (CT) examinations. Despite its essential role in radiology, CT is responsible for raising the collective medical radiation dose to the American population to a level that is associated with measurable and predictable risk for carcinogenic effect today. Accurate knowledge and record of patient organ doses have now become critical in the successful and sustainable use of this imaging modality. It is recognized that existing software are insufficient in meeting the current and future needs involving modern MDCT scanners. Based on unique "virtual patient" technologies and extensive Monte Carlo modeling capabilities and modern software engineering, this proposed software system is expected to improve upon the accuracy and functionality in CT dose estimates. Specific aims of the project are: (1) To adopt a family of anatomically realistic phantoms including the adult male/female, pregnant female, and male/female children with the capability to adjust the body size and shape. (2) To develop a Monte Carlo based computational method for modeling various CT scanners and clinical protocols. (3) To establish a comprehensive organ dose database by using the Monte Carlo CT scanner models and ICRP algorithms. (4) To develop and refine the software graphical user interfaces by using 3D object- oriented programming. PUBLIC HEALTH RELEVANCE: A commercial software is developed to calculate and analyze patient radiation doses from x- ray computed tomography examinations using "virtual patient" technologies, Monte Carlo modeling and modern software engineering.

描述(由申请人提供)：该项目旨在开发一个商业软件产品VirtualDoseTM，用于计算和分析患者从X射线计算机断层扫描(CT)检查中获得的辐射剂量。尽管CT在放射学中起着重要作用，但它负责将美国人口的集体医疗辐射剂量提高到与当今致癌效应的可测量和可预测风险相关的水平。对患者器官剂量的准确了解和记录现在已成为成功和可持续使用这种成像方式的关键。人们认识到，现有软件不足以满足涉及现代多层螺旋CT扫描仪的当前和未来需要。基于独特的“虚拟患者”技术、广泛的蒙特卡罗建模能力和现代软件工程，这一拟议的软件系统有望提高CT剂量估计的准确性和功能。该项目的具体目标是：(1)采用一个解剖上逼真的幻影家庭，包括成年男性/女性、怀孕女性和能够调整身体大小和形状的男性/女性儿童。(2)开发一种基于蒙特卡罗的计算方法，用于模拟各种CT扫描仪和临床方案。(3)利用蒙特卡罗CT扫描仪模型和ICRP算法建立了一个完整的器官剂量数据库。(4)采用三维面向对象的程序设计方法，开发和提炼软件图形用户界面。 与公共健康相关：开发了一个商业软件，利用“虚拟患者”技术、蒙特卡罗建模和现代软件工程，计算和分析X射线计算机断层扫描检查中的患者辐射剂量。