ARCHER - An Extremely Fast Medical Radiation Dose Computing Software

ARCHER - 极快的医疗辐射剂量计算软件

• 批准号: 9340330
• 负责人: Xie George Xu
• 金额: $ 42.95万
• 依托单位: VIRTUAL PHANTOMS, INC.
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-12-15 至 2018-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9340330
• 关键词: Address; Adopted; Algorithms; Architecture; Benchmarking; Cancer Patient; Clinic; Clinical; Code; Complex; Computer software; Computers; Development; Dose; Electrons; Emerging Technologies; Environment; Funding; Future; Future Generations; Gamma Rays; Goals; Health; High Performance Computing; Hour; Human body; Image; Industry; Institutes; Licensing; Malignant neoplasm of prostate; Marketing; Medical; Methods; Modeling; Monte Carlo Method; Nature; Nuclear Weapon; Patients; Performance; Phase; Positioning Attribute; Price; Procedures; Process; Protons; Published Comment; Radiation; Radiation Oncology; Radiation Physics; Radiation therapy; Radiology Specialty; Reporting; Research; Research Personnel; Resources; Scientist; Small Business Technology Transfer Research; Software Design; Software Engineering; Speed; Stream; System; Technology; Testing; Text; Time; Translating; Treatment Protocols; Uncertainty; United States National Institutes of Health; Universities; Wisconsin; Work; base; cancer radiation therapy; clinical practice; computer game; computerized; cost; design; experience; improved; multidisciplinary; novel strategies; oncology; parallel computer; prototype; research and development; research study; response; simulation software; software development; supercomputer; theories; treatment planning; virtual

 DESCRIPTION (provided by applicant): The goal of this project is to develop a commercial software package for rapid Monte Carlo-based dose computation in imaging and radiation therapy. The product takes advantage of a desktop parallel computer equipped with emerging hardware originally developed gaming and high-performance computing. The project is motivated by the fact that the market is ripe for a product that brings massively parallel computing power currently available only to National Labs and major research universities to busy and resource-limited radiology/oncology clinics. The preliminary studies by us, as well as other groups, on this very new research topic have thus far revealed a number of major challenges. Specific Aims: (Phase I Segment) 1. To develop a prototype ARCHER software/hardware system suitable for third-party user testing. 2. To demonstrate performance advantage of ARCHER against clinical radiation treatment planning system. (Phase II Segment) 1. To finish the ARCHER software design for radiation therapy dose calculations using emerging parallel-computing hardware platforms. 2. To systematically benchmark radiation physics modeling using experiments and well-tested Monte Carlo code packages. 3. To evaluate clinical benefits of ARCHER for selected radiation treatment protocols involving prostate cancer patients. 4. To evaluate software user experience for interactive and easy-to-use dose verification and treatment planning.

 描述（由申请人提供）：本项目的目标是开发一个商业软件包，用于成像和放射治疗中基于蒙特卡罗的快速剂量计算。该产品利用了一个桌面并行计算机配备了新兴的硬件最初开发的游戏和高性能计算。该项目的动机是这样一个事实，即市场已经成熟的产品，带来了大规模并行计算能力，目前只有国家实验室和主要的研究大学，忙碌繁忙和资源有限的放射学/肿瘤学诊所。我们和其他小组对这一非常新的研究课题进行的初步研究迄今为止揭示了一些重大挑战。具体目标：（第一阶段）1.开发适合第三方用户测试的原型ARCHER软件/硬件系统。2.证明ARCHER相对于临床放射治疗计划系统的性能优势。（第二阶段）使用新兴的并行计算硬件平台完成ARCHER放射治疗剂量计算软件设计。2.使用实验和经过良好测试的Monte Carlo代码包系统地对辐射物理建模进行基准测试。3.评价ARCHER用于选定的前列腺癌患者放射治疗方案的临床获益。4.旨在评价交互式和易于使用的剂量验证和治疗计划的软件用户体验。