4D Visible Human Modeling for Radiation Dosimetry

描述(由申请人提供)： 用于辐射剂量测量的4D可视人体建模 我们建议进行多学科研究，以解决与患者呼吸运动相关的问题。 在放射治疗期间，通过进一步将可见人图像数据集扩展到具有运动模拟功能的第四维(4D)。放射治疗是肿瘤治疗最有效的方法之一。在体外放射治疗中，致命的辐射剂量通过精确匹配的外部辐射传递到肿瘤，同时保留邻近的健康组织。然而，目前的模式是基于这样的假设，即肿瘤的位置和形状都是已知的，并且在放射治疗过程中保持不变。这种良好的刚体关系在胸腔和腹部等解剖部位并不存在，主要是由于呼吸运动。因此，放射肿瘤学家目前不得不使用不那么激进的治疗策略和大剂量裕度来容忍潜在的靶向错误。我们建议开发基于物理的、模拟运动的虚拟人体模型，该模型将提供对放射治疗期间呼吸运动管理的独特见解，从而允许更积极和有效的靶向和辐射传递。我们组建了一支拥有辐射剂量学、生物力学建模和临床放射肿瘤学专业知识的多学科研究团队，以实现以下具体目标：1)将基于高分辨率VHP冷冻图像数据开发的成年男性3D解剖模型与基于物理的组织变形模型相结合，以模拟呼吸运动。2)将这第一个基于物理学的4D运动模拟虚拟人应用于使用先进的蒙特卡罗模拟来研究组织中复杂的辐射相互作用和不同辐射传递策略的剂量分布模式，3)批判性地评估更逼真的内部器官表示将在多大程度上改善计划和提供的治疗剂量。4)建立基于互联网的虚拟人运动仿真和辐射剂量学信息共享资源。

DESCRIPTION (provided by applicant): 4D Visible Human Modeling for Radiation Dosimetry We propose a multidisciplinary research to solve problems associated with patient respiratory motions during radiation therapy by further extending the Visible Human image dataset into the 4th dimension (4D) with motion-simulating capabilities. Radiation therapy is one of the most effective methods of cancer management. In external beam radiation treatment, a lethal radiation dose is delivered through precisely conformed external radiation to the tumor while sparing the adjacent healthy tissues. However, the current paradigm is based on an assumption that both the tumor location and shape are known and remain unchanged during the course of radiation delivery. Such a favorable rigid-body relationship does not exist in anatomical sites such as the thoracic cavity and the abdomen, owing predominantly to respiratory motions. Consequently, the radiation oncologists currently have to use less aggressive treatment strategies with a large dose margin to tolerate potential targeting errors. We propose to develop physics-based, motion-simulating virtual human models that will provide a unique insight into the management of respiratory motion during radiation treatment, thus allowing for more aggressive and effective targeting and radiation delivery. A multidisciplinary research team with collective expertise in radiation dosimetry, biomechanical modeling and clinical radiation oncology is assembled to achieve the following Specific Aims: 1) To combine the 3D adult male anatomical model developed from high-resolution VHP cryosection image data with physics-based tissue deformation models to simulate respiratory motions. 2.)To apply this first physics-based, 4D motion-simulating virtual-human to the study of complex radiation interactions in tissues and dose distribution patterns for various radiation delivery strategies using advanced Monte Carlo simulations, 3).To critically evaluate the degrees to which the more realistic representations of internal organs will improve the planned and delivered treatment doses. 4).To establish an internet-based information-sharing resource on virtual-human motion simulation and radiation dosimetry.