Biomechanics in Regenerative Medicine (BiRM) Training Program

再生医学生物力学 (BiRM) 培训计划

• 批准号: 10628407
• 负责人: David Alan Vorp
• 金额: $ 22.23万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10628407
• 关键词: Biomechanics; Regenerative Medicine; Training Programs

This is a new application for continued support of a unique, vibrant, multi-institutional and multi-disciplinary pre- doctoral training program entitled “Biomechanics in Regenerative Medicine (BiRM)” jointly run by the Departments of Bioengineering at the University of Pittsburgh and Biomedical Engineering at Carnegie Mellon University. For the past 16 years, 38 trainees have gained a solid foundation that has led to independent careers in academia (n=10), industry (n=24), and government (n=4) with an additional seven (7) trainees currently enrolled. BiRM is an innovative training program with an in depth focus on multi-scale biomechanics as applied to regenerative medicine for the development or repair of tissues (and organs?) whose primary physiological function is mechanical. As the field of regenerative medicine matures, it is necessary to arm the next generation engineering workforce with a deeper understanding of multi-scale biomechanics, the relationship between biomechanics and growth and remodeling (mechanobiology), and the biological basis of repair and regeneration. To accomplish these, we will also hone our trainees with skills in contemporary engineering technologies (e.g., artificial intelligence (AI), mechatronics, robotics, computation, process control, and manufacturing). BiRM leverages the didactic and research experiences of distinct strengths and resources of two major universities plus clinical experience of a World-class medical center all located adjacent to one another without administrative roadblocks in conventional cross-institutional programs. Trainee candidates are primarily from bioengineering, but we also welcome those from other disciplines. Another unique aspect of BiRM is the significant clinical exposure for trainees (including a mandatory clinical mentor) to aid in appreciation of the enormous potential, opportunity, and challenge of translating regenerative medicine technologies. Similarly, challenges and opportunities in biomanufacturing and large-scale production of regenerative medicine technologies will be imparted to the trainees with our unique partnership with the Advanced Regenerative Manufacturing Institute. Professional and career development are offered, including innovation and entrepreneurship. In the next five years, we aim to maintain 6 pre-doctoral fellowships per year. Our multi-institutional program will provide a unique opportunity for our trainees to 1) develop key collaborative and multidisciplinary skills on multi- scale biomechanics, 2) to prepare them to enter the future regenerative medicine workforce as the field moves from conception to reality, and 3) to become innovators in upstream research and downstream production for the next generation of technologies.

这是一个新的应用程序，旨在持续支持独特的、充满活力的、多机构和多学科的预科项目。 与中科院联合举办“再生医学生物力学（BiRM）”博士生培养项目 匹兹堡大学生物工程系和卡内基梅隆大学生物医学工程系 大学。 16年来，38名学员奠定了独立职业生涯的坚实基础 在学术界 (n=10)、工业界 (n=24) 和政府 (n=4)，目前还有七 (7) 名学员 已注册。 BiRM 是一项创新培训计划，深入关注多尺度生物力学的应用 再生医学用于发育或修复其主要生理功能的组织（和器官？） 功能是机械的。随着再生医学领域的成熟，需要武装下一代 工程人员对多尺度生物力学、之间的关系有更深入的了解 生物力学、生长和重塑（力学生物学），以及修复和再生的生物学基础。 为了实现这些目标，我们还将磨练学员当代工程技术的技能（例如， 人工智能 (AI)、机电一体化、机器人、计算、过程控制和制造）。 BiRM 利用两所主要大学的独特优势和资源的教学和研究经验 加上世界一流医疗中心的临床经验，这些中心彼此相邻，无需行政管理 传统跨机构项目的障碍。 实习生候选人主要来自生物工程，但我们也欢迎来自其他学科的人。其他 BiRM 的独特之处在于受训者（包括强制性临床导师）有大量的临床经验 帮助认识转化再生医学的巨大潜力、机遇和挑战 技术。同样，生物制造和大规模生产的挑战和机遇 再生医学技术将通过我们与 先进再生制造研究所。提供专业和职业发展，包括 创新创业。 未来五年，我们的目标是保持每年 6 个博士前奖学金。我们的多机构计划将 为我们的学员提供独特的机会：1）培养多方面的关键协作和多学科技能 规模生物力学，2) 让他们做好准备，随着该领域的发展进入未来的再生医学队伍 从构想到现实，3）成为上游研究和下游生产的创新者 下一代技术。