Frontiers in Lipid Biology

描述(由申请者提供)：本申请是为一个由美国生物化学和分子生物学协会(ASBMB)主办的名为“脂质生物学前沿”的独特国际会议提供部分支持。这次会议将汇集科学家，他们将展示、交流和传播他们的研究，并探索未来可能的合作。这次会议由ASBMB、国际脂质生物科学会议(ICBL)和加拿大脂蛋白会议(CLC)联合举办。预计出席人数为250至300人。参加者包括遗传学家、内科科学家、分子生物学家、生物化学家、细胞生物学家、生理学家和结构生物学家，以及工业界的科学家和许多受训人员。该计划将侧重于脂类生物学中的新兴课题，包括脂代谢的遗传调控、脂肪储存的调控、脂类的细胞生物学、脂运输、脂信号、膜动力学以及肺部疾病、神经退行性疾病、心脏病、2型糖尿病和肥胖症中的脂平衡障碍。ICBL和CLC各自举办了关于脂类代谢的年度会议，分别参加了52年和35年。重要的是，今年的会议由ASBMB共同主办，是一次“特别研讨会”。因此，这次独特的联合会议将由美国、加拿大和欧洲的科学家组织，并将提供一个独特的机会，将来自不同国际背景的脂质生物学家聚集在一起。会议将于2012年9月5日至9日在加拿大班夫的班夫中心举行。会议将聚焦于人们越来越多地认识到，脂代谢失调是许多人类疾病发展的基础，如肥胖、动脉粥样硬化、代谢综合征、肝和肺疾病以及神经退行性疾病。该计划包括7个科学会议，每个会议将有3到4次演讲，每次30分钟长，外加10分钟的讨论。这次会议的一个特点是强调研究生、博士后研究员和初级教员的演讲。国际公认的科学家将因他们在科学上的卓越表现以及他们清楚而有逻辑地介绍其工作的能力而被选中，他们将在每一次会议上发表演讲。此外，每天将有3.5小时用于海报演示，这将为学员和知名科学家之间的非正式讨论提供一个极好的论坛。该计划和组委会包括来自不同种族的杰出女性和男性科学家。与公共卫生相关：西方世界最流行的人类疾病的特点是脂类平衡失调。例如，以脂肪(甘油三酯)的形式储存的过量脂肪会导致与肥胖、脂肪肝和2型糖尿病相关的健康问题。血浆胆固醇过高会显著增加动脉粥样硬化的风险，并与阿尔茨海默病等几种神经退行性疾病有关。这次独特的国际会议将讨论脂类代谢过程中的当前问题及其与人类疾病的关系。脂肪合成、分解和储存的基本过程将在从基本机制到临床意义的研究中讨论。因此，会议将汇集国际公认的基础科学家和内科科学家，介绍他们关于脂代谢过程障碍如何导致动脉粥样硬化、肥胖症、2型糖尿病、肝和肺疾病以及神经退化等疾病的最新数据。

DESCRIPTION (provided by applicant): This application is for partial support of a unique international conference sponsored by the American Society of Biochemistry and Molecular Biology (ASBMB) and entitled "Frontiers in Lipid Biology". This conference will bring together scientists who will present, exchange and disseminate their research and explore possible future collaborations. The conference is jointly organized by ASBMB, the International Conference on the Bioscience of Lipids (ICBL) and the Canadian Lipoprotein Conference (CLC). The expected number of attendees is 250 to 300. The participants will include geneticists, physician scientists, molecular biologists, biochemists, cell biologists, physiologist and structural biologists, as well as scientists from industry and many trainees. The program will focus on emerging topics in lipid biology including genetic regulation of lipid metabolism, regulation of fat storage, cell biology of lipids, lipid trafficking, lipid signaling, membrane dynamics, as well as impairment of lipid homeostasis in lung disease, neurodegenerative diseases, heart disease, type 2 diabetes and obesity. The ICBL and the CLC each hold annual conferences on lipid metabolism that have been well attended for 52 and 35 years, respectively. Importantly, this year's conference is co-sponsored by the ASBMB as a "Special Symposium". Thus, this unique combined meeting will be organized by scientists based in the US, Canada and Europe, and will provide a unique opportunity to bring together lipid biologists from diverse international backgrounds. The conference will take place from Sept 5 to 9, 2012, at the Banff Centre in Banff, Canada. The conference will focus on the growing recognition that dysfunctional lipid metabolism underlies the development of many human diseases such as obesity, atherosclerosis, metabolic syndrome, liver and lung disease and neurodegenerative disorders. The program includes 7 scientific sessions that will each feature 3 or 4 talks, each 30 min long plus 10 min discussion. A special feature of this conference is the emphasis on presentations by graduate students, postdoctoral fellows and junior faculty. Internationally recognized scientists who will be selected for their scientific excellence as well as their abilityto present their work clearly and logically will give talks in each of the sessions. In addition, 3.5 hours each day will be devoted to poster presentations that will provide an excellent forum for informal discussions among trainees and established scientists. The program and the organizing committee include outstanding women and men scientists of diverse ethnicities. PUBLIC HEALTH RELEVANCE: The most prevalent human diseases in the western world are characterized by dysregulation of lipid homeostasis. For example, excess lipids that is stored as fat (triglycerides) contribute to health problems associated with obesity, fatty liver and type 2 diabetes. An excess of plasma cholesterol markedly increases the risk of atherosclerosis and has been associated with several neurodegenerative diseases such as Alzheimer disease. This unique international conference will address current issues in lipid metabolic processes and their relationship to human disease. The fundamental processes of lipid synthesis, breakdown and storage will be discussed in studies that range from basic mechanisms to clinical implications. The meeting will, therefore, bring together internationally recognized basic scientists and physician scientists to present their latest data on how impairment of lipid metabolic processes contribute to the development of disorders such as atherosclerosis, obesity, type 2 diabetes, liver and lung disease and neurodegeneration.