Frontiers in Lipid Biology

描述（由申请人提供）：本申请是为了部分支持由美国生物化学和分子生物学学会（ASBMB）主办的名为“脂质生物学前沿”的独特国际会议。本次会议将汇集科学家，他们将展示、交流和传播他们的研究，并探讨未来可能的合作。会议由ASBMB、国际脂质生物科学会议（ICBL）和加拿大脂蛋白会议（CLC）联合举办。预计参加人数为250至300人。与会者将包括遗传学家、内科科学家、分子生物学家、生物化学家、细胞生物学家、生理学家和结构生物学家，以及来自工业界的科学家和许多学员。该计划将重点关注脂质生物学中的新兴主题，包括脂质代谢的遗传调控、脂肪储存的调控、脂质细胞生物学、脂质运输、脂质信号传导、膜动力学，以及肺部疾病、神经退行性疾病、心脏病、2型糖尿病和肥胖症中脂质稳态的损害。ICBL和CLC每年召开一次关于脂质代谢的会议，分别有52年和35年的历史。重要的是，今年的会议是ASBMB作为“专题研讨会”共同主办的。因此，这次独特的联合会议将由美国，加拿大和欧洲的科学家组织，并将提供一个独特的机会，将来自不同国际背景的脂质生物学家聚集在一起。会议将于2012年9月5日至9日在加拿大班夫的班夫中心举行。会议将重点关注越来越多的人认识到，脂质代谢功能失调是许多人类疾病（如肥胖、动脉粥样硬化、代谢综合征、肝脏和肺部疾病以及神经退行性疾病）发展的基础。该计划包括7个科学会议，每个会议将有3或4个演讲，每个30分钟加上10分钟的讨论。这次会议的一个特别之处在于强调研究生、博士后研究员和初级教师的演讲。国际公认的科学家将因其卓越的科学成就以及清晰而有逻辑地展示其工作的能力而被选中，他们将在每次会议上发表演讲。此外，每天将有3.5小时用于海报展示，这将为学员和知名科学家之间的非正式讨论提供一个极好的论坛。该项目和组委会包括来自不同种族的杰出男女科学家。公共卫生相关性：西方世界最普遍的人类疾病以脂质稳态失调为特征。例如，储存为脂肪的过量脂质（甘油三酯）会导致与肥胖、脂肪肝和2型糖尿病相关的健康问题。血浆胆固醇过高会显著增加动脉粥样硬化的风险，并与阿尔茨海默病等几种神经退行性疾病有关。这次独特的国际会议将讨论当前脂质代谢过程及其与人类疾病的关系。脂质合成、分解和储存的基本过程将在从基本机制到临床意义的研究中讨论。因此，会议将汇集国际公认的基础科学家和内科科学家，展示他们关于脂质代谢过程损伤如何导致动脉粥样硬化、肥胖、2型糖尿病、肝脏和肺部疾病以及神经变性等疾病发展的最新数据。

DESCRIPTION (provided by applicant): This application is for partial support of a unique international conference sponsored by the American Society of Biochemistry and Molecular Biology (ASBMB) and entitled "Frontiers in Lipid Biology". This conference will bring together scientists who will present, exchange and disseminate their research and explore possible future collaborations. The conference is jointly organized by ASBMB, the International Conference on the Bioscience of Lipids (ICBL) and the Canadian Lipoprotein Conference (CLC). The expected number of attendees is 250 to 300. The participants will include geneticists, physician scientists, molecular biologists, biochemists, cell biologists, physiologist and structural biologists, as well as scientists from industry and many trainees. The program will focus on emerging topics in lipid biology including genetic regulation of lipid metabolism, regulation of fat storage, cell biology of lipids, lipid trafficking, lipid signaling, membrane dynamics, as well as impairment of lipid homeostasis in lung disease, neurodegenerative diseases, heart disease, type 2 diabetes and obesity. The ICBL and the CLC each hold annual conferences on lipid metabolism that have been well attended for 52 and 35 years, respectively. Importantly, this year's conference is co-sponsored by the ASBMB as a "Special Symposium". Thus, this unique combined meeting will be organized by scientists based in the US, Canada and Europe, and will provide a unique opportunity to bring together lipid biologists from diverse international backgrounds. The conference will take place from Sept 5 to 9, 2012, at the Banff Centre in Banff, Canada. The conference will focus on the growing recognition that dysfunctional lipid metabolism underlies the development of many human diseases such as obesity, atherosclerosis, metabolic syndrome, liver and lung disease and neurodegenerative disorders. The program includes 7 scientific sessions that will each feature 3 or 4 talks, each 30 min long plus 10 min discussion. A special feature of this conference is the emphasis on presentations by graduate students, postdoctoral fellows and junior faculty. Internationally recognized scientists who will be selected for their scientific excellence as well as their abilityto present their work clearly and logically will give talks in each of the sessions. In addition, 3.5 hours each day will be devoted to poster presentations that will provide an excellent forum for informal discussions among trainees and established scientists. The program and the organizing committee include outstanding women and men scientists of diverse ethnicities. PUBLIC HEALTH RELEVANCE: The most prevalent human diseases in the western world are characterized by dysregulation of lipid homeostasis. For example, excess lipids that is stored as fat (triglycerides) contribute to health problems associated with obesity, fatty liver and type 2 diabetes. An excess of plasma cholesterol markedly increases the risk of atherosclerosis and has been associated with several neurodegenerative diseases such as Alzheimer disease. This unique international conference will address current issues in lipid metabolic processes and their relationship to human disease. The fundamental processes of lipid synthesis, breakdown and storage will be discussed in studies that range from basic mechanisms to clinical implications. The meeting will, therefore, bring together internationally recognized basic scientists and physician scientists to present their latest data on how impairment of lipid metabolic processes contribute to the development of disorders such as atherosclerosis, obesity, type 2 diabetes, liver and lung disease and neurodegeneration.