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MicroRNA regulation of cell survival in angiogenesis and vessel maturation

MicroRNA对血管生成和血管成熟中细胞存活的调节

基本信息

批准号：
8279906
负责人：
Sudarshan Anand
金额：
$ 9.79万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-06-01 至 2014-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8279906
关键词：
Address Affect Angiogenic Factor Apoptosis Apoptotic Attenuated Blood Vessels Cell Death Cell Proliferation Cell Survival Cell physiology Cells Complex Development Disease Endothelial Cells Equilibrium Functional RNA Genome Growth Growth Factor Hemangioma Human In Vitro Inflammation Laboratories Macular degeneration Malignant Neoplasms Mediating Mediator of activation protein Medicine Mentors MicroRNAs Modeling Nature Neonatal Neoplasms in Vascular Tissue Notch Signaling Pathway Pathologic Neovascularization Pathology Pathway interactions Pattern Phase Physiological Processes Process Regulation Research Rest Retinal Diseases Retinal Hemangioma Role Signal Transduction Small RNA Smooth Muscle Myocytes Starvation Stem cells Stimulus Strawberry nevus Stress Tissues Training Tumor Suppressor Genes Work Xenograft Model angiogenesis biological adaptation to stress human disease in vivo malformation mouse model notch protein p120 GTPase Activating Protein postnatal programs response retinal angiogenesis

项目摘要

DESCRIPTION (provided by applicant): Aberrant growth of blood vessels termed 'angiogenesis' contributes to the pathology of several human diseases ranging from macular degeneration, retinopathy to inflammation and cancer. Recently small RNAs encoded in the genome termed microRNAs have been implicated in the regulation of diverse physiological processes including angiogenesis. We recently profiled microRNAs during activation of endothelial cells and identified microRNA-132 as a critical regulator of p120RasGAP during pathological neovascularization. In this proposal, I will characterize the role of miR-132/p120RasGAP in cell survival during stress responses in the vasculature using in vitro and in vivo angiogenesis models during the mentored phase. Using these models, in the independent phase, I will analyze the contribution of a different microRNA that functions as a negative regulator of cell survival in vascular cells. These studies will elucidate how distinct microRNA programs govern the balance between the pro and anti-angiogenic states in the vasculature during development and disease.

描述（由申请人提供）：被称为“血管生成”的血管异常生长导致多种人类疾病的病理学，包括黄斑变性、视网膜病、炎症和癌症。最近，基因组中编码的小RNA（称为microRNA）与包括血管生成在内的多种生理过程的调节有关。我们最近分析了内皮细胞激活过程中的 microRNA，并确定 microRNA-132 是病理性新生血管形成过程中 p120RasGAP 的关键调节因子。在本提案中，我将在指导阶段使用体外和体内血管生成模型来描述 miR-132/p120RasGAP 在脉管系统应激反应期间细胞存活中的作用。使用这些模型，在独立阶段，我将分析不同 microRNA 的贡献，该 microRNA 作为血管细胞中细胞存活的负调节因子。这些研究将阐明不同的 microRNA 程序如何控制发育和疾病期间脉管系统中促血管生成状态和抗血管生成状态之间的平衡。