MicroRNA Regulation Of Cell Survival In Angiogenesis & Vessel Maturation

血管生成中细胞存活的 MicroRNA 调节

• 批准号: 8828397
• 负责人: Sudarshan Anand
• 金额: $ 24.9万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-05-01 至 2017-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8828397
• 关键词: Address; Affect; Angiogenic Factor; Apoptosis; Apoptotic; Attenuated; Blood Vessels; Cell Death; Cell Proliferation; Cell Survival; Cell physiology; Cells; Complex; Development; Disease; Endothelial Cells; Equilibrium; Functional RNA; Genome; Growth; Growth Factor; Hemangioma; Human; In Vitro; Inflammation; Laboratories; Macular degeneration; Malignant Neoplasms; Mediating; Mediator of activation protein; Medicine; Mentors; MicroRNAs; Modeling; Nature; Neonatal; Neoplasms in Vascular Tissue; Notch Signaling Pathway; Pathologic Neovascularization; Pathology; Pathway interactions; Pattern; Phase; Physiological Processes; Process; Regulation; Research; Rest; Retinal Diseases; Retinal Hemangioma; Role; Signal Transduction; Small RNA; Smooth Muscle Myocytes; Starvation; Stem cells; Stimulus; Strawberry nevus; Stress; Tissues; Training; Tumor Suppressor Genes; Work; Xenograft Model; angiogenesis; biological adaptation to stress; human disease; in vivo; malformation; mouse model; notch protein; p120 GTPase Activating Protein; postnatal; programs; response; retinal angiogenesis

PROJECT SUMMARY/ABSTRACT Aberrant growth of blood vessels termed 'angiogenesis' contributes to the pathology of several human diseases ranging from macular degeneration, retinopathy to inflammation and cancer. Recently small RNAs encoded in the genome termed microRNAs have been implicated in the regulation of diverse physiological processes including angiogenesis. We recently profiled microRNAs during activation of endothelial cells and identified microRNA-132 as a critical regulator of p120RasGAP during pathological neovascularization. In this proposal, I will characterize the role of miR-132/p120RasGAP in cell survival during stress responses in the vasculature using in vitro and in vivo angiogenesis models during the mentored phase. Using these models, in the independent phase, I will analyze the contribution of a different microRNA that functions as a negative regulator of cell survival in vascular cells. These studies will elucidate how distinct microRNA programs govern the balance between the pro and anti-angiogenic states in the vasculature during development and disease.

项目总结/文摘