VisualSonics Photoacoustic and Ultrasound Imaging System
VisualSonics 光声和超声成像系统
基本信息
- 批准号:8334908
- 负责人:
- 金额:$ 91.22万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-07-15 至 2013-07-14
- 项目状态:已结题
- 来源:
- 关键词:Animal ExperimentationAnimalsAntibiotic ResistanceAreaBiomedical ResearchBostonBrainCardiovascular DiseasesCommitComplementDermatologyDiseaseFill-ItFunctional disorderFundingGrantHousingImageImaging technologyInfectionInvestigationMalignant NeoplasmsMeasuresMedicineMinorNervous System TraumaPathologyPhysiologic MonitoringPhysiologicalProductivityRadiology SpecialtyRequest for ProposalsResearchResearch PersonnelResolutionScientistSystemTechnologyThree-Dimensional ImageTimeTissuesTranslatingUltrasonographyUnited States National Institutes of Healthclinical practicecost effectivedesignexperiencehemodynamicsinsightinstrumentneurological pathologyoptical imagingpre-clinicaltissue oxygenationtreatment planning
项目摘要
DESCRIPTION (provided by applicant): This proposal requests NIH support to purchase a VisualSonics Vevo LAZR Photoacoustic and Ultrasound (PA/US) Imaging system. This system is a uniquely integrated imaging system specifically designed for pre-clinical small animal research. This acquisition will reduce the number of animals sacrificed for studies and enable cost-effective, robust longitudinal investigations. The instrument will serve 4 different departments, 16 NIH funded grant projects as major users and 3 projects as minor users spanning a diverse array of topics. It fills a critical need as the existing systems in the Boston area, are not accessible either due to being housed in BL3 facilities, committed to single project use or being located at inconvenient distances. Key applications are listed below, where, by combining photoacoustic and ultrasound technologies into a single, integrated Vevo system, the will provide enhanced capabilities to: " Simultaneously capture and present in real time, both physiological and anatomical information of the imaged target " Obtain non-invasively high resolution 3D images for treatment planning, of tissue at a depth not obtainable with other optical imaging technologies " Measure tissue oxygenation and hemodynamics " Longitudinally monitor the physiological and anatomical changes in the same animal The investigators participating in this proposal from MGH's Wellman Center for Photomedicine (Dermatology and Pathology), Martinos Center (Radiology) and Cardiovascluar Research Center (Medicine) represent leading researchers in biomedical research focused on using imaging technology to understand the pathophysiology of a diverse array of high impact diseases such as cancer, cardiovascular disease, abnormal brain function, neurological pathologies and injury, and antibiotic resistant infections, and on translating that insight into clinical practice. Collectivey, these scientists have experience using the most sophisticated optical imaging technologies currently available to biomedical research, each of which has its own intrinsic strengths and weaknesses. As a group, they have determined that the capabilities of the recently commercially available VisualSonics PA/US instrument will complement, currently used systems. It will greatly enhance the quality and productivity of their research.
描述(由申请人提供):本提案请求 NIH 支持购买 VisualSonics Vevo LAZR 光声和超声(宾夕法尼亚州/美国)成像系统。该系统是一个独特的集成成像系统,专为临床前小动物研究而设计。此次收购将减少研究中牺牲的动物数量,并实现具有成本效益、稳健的纵向研究。该仪器将为 4 个不同的部门、16 个 NIH 资助的赠款项目(作为主要用户)和 3 个项目(作为次要用户)提供服务,涵盖各种主题。它满足了一项关键需求,因为波士顿地区的现有系统由于位于 BL3 设施中、致力于单一项目使用或位于不方便的距离而无法访问。下面列出了主要应用,其中,通过将光声和超声技术结合到一个集成的 Vevo 系统中,将提供增强的功能: “同时捕获并实时呈现成像目标的生理和解剖信息” 获得其他光学成像技术无法获得的深度组织的非侵入性高分辨率 3D 图像,用于治疗计划“ 测量组织氧合和 参与这项提案的研究人员来自麻省总医院威尔曼光医学中心(皮肤病学和病理学)、马蒂诺斯中心(放射学)和心血管研究中心(医学),他们代表了生物医学研究领域的领先研究人员,专注于利用成像技术来了解多种高影响疾病的病理生理学,例如 癌症、心血管疾病、脑功能异常、神经病理和损伤以及抗生素耐药性感染,并将这些见解转化为临床实践。总的来说,这些科学家拥有使用目前可用于生物医学研究的最先进光学成像技术的经验,每种技术都有其固有的优点和缺点。作为一个团队,他们确定最近商用的 VisualSonics PA/US 仪器的功能将补充当前使用的系统。这将极大地提高他们的研究质量和生产力。
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Development and evaluation of a low-cost, portable, LED-based device for PDT treatment of early-stage oral cancer in resource-limited settings.
- DOI:10.1002/lsm.23019
- 发表时间:2019-04
- 期刊:
- 影响因子:2.4
- 作者:Liu H;Daly L;Rudd G;Khan AP;Mallidi S;Liu Y;Cuckov F;Hasan T;Celli JP
- 通讯作者:Celli JP
DNA-Based Photoacoustic Nanosensor for Interferon Gamma Detection.
- DOI:10.1021/acssensors.9b00209
- 发表时间:2019-04
- 期刊:
- 影响因子:8.9
- 作者:Jennifer M. Morales;R. Pawle;N. Akkilic;Yi Luo;Marvin Xavierselvan;Rayan Albokhari;I. Calderon;Scott Selfridge;R. Minns;L. Takiff;S. Mallidi;H. Clark
- 通讯作者:Jennifer M. Morales;R. Pawle;N. Akkilic;Yi Luo;Marvin Xavierselvan;Rayan Albokhari;I. Calderon;Scott Selfridge;R. Minns;L. Takiff;S. Mallidi;H. Clark
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Tayyaba Hasan其他文献
Tayyaba Hasan的其他文献
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{{ truncateString('Tayyaba Hasan', 18)}}的其他基金
17th Biennial International Photodynamic Association World Congress
第十七届双年度国际光动力协会世界大会
- 批准号:
9763031 - 财政年份:2019
- 资助金额:
$ 91.22万 - 项目类别:
Dual function theranostic constructs for photoacoustic guided surgery and photodynamic therapy
用于光声引导手术和光动力治疗的双功能治疗诊断结构
- 批准号:
10381460 - 财政年份:2019
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$ 91.22万 - 项目类别:
Optical imaging guided resection and photodynamic therapy of glioma with targeted photoactivable agents
光学成像引导的神经胶质瘤切除和光动力治疗与靶向光活化剂
- 批准号:
9753714 - 财政年份:2017
- 资助金额:
$ 91.22万 - 项目类别:
Optical imaging guided resection and photodynamic therapy of glioma with targeted photoactivable agents
光学成像引导的神经胶质瘤切除和光动力治疗与靶向光活化剂
- 批准号:
9381959 - 财政年份:2017
- 资助金额:
$ 91.22万 - 项目类别:
Ovarian Cancer PDT: Multi-intracellular targeting and Image-guided dosimetry
卵巢癌 PDT:多细胞内靶向和图像引导剂量测定
- 批准号:
8162492 - 财政年份:2011
- 资助金额:
$ 91.22万 - 项目类别:
Heterocellular 3D ovarian tumor arrays for imaging and mechanistic combinations
用于成像和机械组合的异细胞 3D 卵巢肿瘤阵列
- 批准号:
8238894 - 财政年份:2011
- 资助金额:
$ 91.22万 - 项目类别:
Ovarian Cancer PDT: Multi-intracellular targeting and Image-guided dosimetry
卵巢癌 PDT:多细胞内靶向和图像引导剂量测定
- 批准号:
8306721 - 财政年份:2011
- 资助金额:
$ 91.22万 - 项目类别:
Targeted Photoactivable Nanocells: Image-based Drug Delivery and Dosimetry in GBM
靶向光敏纳米细胞:GBM 中基于图像的药物输送和剂量测定
- 批准号:
8598080 - 财政年份:2011
- 资助金额:
$ 91.22万 - 项目类别:
Targeted Photoactivable Nanocells: Image-based Drug Delivery and Dosimetry in GBM
靶向光敏纳米细胞:GBM 中基于图像的药物输送和剂量测定
- 批准号:
8786064 - 财政年份:2011
- 资助金额:
$ 91.22万 - 项目类别:
Targeted Photoactivable Nanocells: Image-based Drug Delivery and Dosimetry in GBM
靶向光敏纳米细胞:GBM 中基于图像的药物输送和剂量测定
- 批准号:
8034651 - 财政年份:2011
- 资助金额:
$ 91.22万 - 项目类别:
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