Development and evaluation of a low-cost, portable, LED-based device for PDT treatment of early-stage oral cancer in resource-limited settings.
Development and evaluation of a low-cost, portable, LED-based device for PDT treatment of early-stage oral cancer in resource-limited settings.
复制标题
DOI：
10.1002/lsm.23019
复制
发表时间：
2019-04
影响因子：
2.4
通讯作者：
Celli JP
中科院分区：
文献类型：
--
作者：
Liu H;Daly L;Rudd G;Khan AP;Mallidi S;Liu Y;Cuckov F;Hasan T;Celli JP
采用δ-氨基乙酰丙酸（ALA）光敏的光动力疗法（PDT）在临床研究中显示出治疗早期口腔恶性肿瘤的前景，与传统疗法相比，其潜在副作用更少。在医疗基础设施有限的情况下，也可以对口腔病变进行轻递送，这表明在全球卫生环境中实施PDT的潜力。我们试图开发一种具有成本效益的、电池供电的、光纤耦合的PDT系统，该系统适用于通过智能手机接口和嵌入式电子设备实现的口腔内光传输，以方便操作。通过测量光功率输出、光谱稳定性和ala光敏鳞状癌细胞培养物和小鼠皮下肿瘤异种移植物的PDT反应的临床前评估来评估设备性能。该系统实现了目标光电性能，在PpIX激活所需的光谱窗口内，光纤尖端稳定的电池供电输出功率约为180 mW。该装置结构紧凑，操作方便，可灵活地为口腔输送光。在细胞培养中，我们发现总体剂量反应与既定光源一致，ALA光敏细胞在辐照区可以完全死亡。体内PDT反应（肿瘤体积减少）与商用635 nm激光相当。我们开发了一种低成本、基于led的光纤耦合PDT光源，该光源具有稳定的电池输出功率，并且适合在农村和/或资源有限的环境中部署。
Photodynamic therapy (PDT) using δ-aminolevulinic acid (ALA) photosensitization has shown promise in clinical studies for the treatment of early-stage oral malignancies with fewer potential side effects than traditional therapies. Light delivery to oral lesions can also carried out with limited medical infrastructure suggesting the potential for implementation of PDT in global health settings. We sought to develop a cost-effective, battery-powered, fiber-coupled PDT system suitable for intraoral light delivery enabled by smartphone interface and embedded electronics for ease of operation. Device performance was assessed in measurements of optical power output, spectral stability, and preclinical assessment of PDT response in ALA-photosensitized squamous carcinoma cell cultures and murine subcutaneous tumor xenografts. The system achieves target optoelectronic performance with a stable battery-powered output of approximately 180 mW from the fiber tip within the desired spectral window for PpIX activation. The device has a compact configuration, user friendly operation and flexible light delivery for the oral cavity. In cell culture, we show that the overall dose-response is consistent with established light sources and complete cell death of ALA photosensitized cells can be achieved in the irradiated zone. In vivo PDT response (reduction in tumor volume) is comparable with a commercial 635 nm laser. We developed a low-cost, LED-based, fiber-coupled PDT light delivery source that has stable output on battery power and suitable form factor for deployment in rural and/or resource-limited settings.
登录
查看更多内容
影响因子：
3.4
作者：
Pogue, BW;Hasan, T
通讯作者：
Hasan, T
影响因子：
3.5
作者：
Mallidi, Srivalleesha;Mai, Zhiming;Hasan, Tayyaba
通讯作者：
Hasan, Tayyaba
DOI：
10.1016/s1011-1344(97)00124-3
发表时间：
1998-01-01
影响因子：
5.4
作者：
Muller, S;Walt, H;Haller, U
通讯作者：
Haller, U
影响因子：
62.1
作者：
Celli, Jonathan P.;Spring, Bryan Q.;Rizvi, Imran;Evans, Conor L.;Samkoe, Kimberley S.;Verma, Sarika;Pogue, Brian W.;Hasan, Tayyaba
通讯作者：
Hasan, Tayyaba
影响因子：
2.4
作者：
Yu, Chuan-Hang;Lin, Hung-Pin;Chiang, Chun-Pin
通讯作者：
Chiang, Chun-Pin