Improving anti-cancer therapy by stromal targeting and remodelling

通过基质靶向和重塑改善抗癌治疗

• 批准号: nhmrc : GNT1122108
• 负责人: A/Pr Juliana Hamzah
• 金额: $ 67.37万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/improving-anti-cancer-targeting-remodelling/1347248
• 关键词: Improving; anti; cancer; therapy; stromal

We have developed a new drug which binds to abnormal cancer blood vessels. Upon binding, shape and tone of cancer vessels are restored and they become tighter. Our research will now test whether combining this new drug with current standard-of-care therapies such as chemo- and immunotherapy, will improve cytotoxic drugs and also make the immune system work better to fight the cancer. We also expect that tightening of blood vessels will stop cancer cells from spreading throughout the body.

我们已经研制出一种新药，它能与不正常的癌血管结合。在结合后，癌血管的形状和色调得到恢复，它们变得更紧。我们的研究现在将测试这种新药与目前的标准治疗方法（如化疗和免疫治疗）相结合是否会改善细胞毒性药物，并使免疫系统更好地对抗癌症。我们还预计血管的收紧将阻止癌细胞在全身扩散。