Improving cancer diagnostic imaging and drug delivery by breaking down extracellular matrix barriers

通过打破细胞外基质屏障改善癌症诊断成像和药物输送

• 批准号: nhmrc : GNT1121131
• 负责人: A/Pr Juliana Hamzah
• 金额: $ 74.82万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/improving-cancer-diagnostic-matrix-barriers/1347186
• 关键词: Improving; cancer; diagnostic; imaging; drug

Solid tumours are stiffer than normal tissues. This stiffness is caused by over-production of non-cellular components known as extracellular matrix (ECM). ECM creates a barrier that restricts drug access in tumours. New methods to overcome tumour stiffness are crucial to improve drug delivery. We will study the use of a new compound to degrade tumour ECM to improve anti-cancer drug delivery. Our compound will be useful in treatment-resistant solid tumours such as breast and liver cancers.

实体瘤比正常组织硬。这种僵硬是由被称为细胞外基质（ECM）的非细胞成分的过度产生引起的。ECM形成了一个限制肿瘤中药物进入的屏障。克服肿瘤硬度的新方法对于改善药物输送至关重要。我们将研究使用一种新的化合物来降解肿瘤ECM，以改善抗癌药物的输送。我们的化合物将用于治疗耐药的实体瘤，如乳腺癌和肝癌。