ANTI-THROMBOGENIC MEMBRANE-MIMETIC ASSEMBLIES

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 子项目的主要研究者可能是由其他来源提供的， 包括其它NIH来源。 为子项目列出的总成本可能 表示子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 本项目的目标是开发和评价血液接触生物材料，该材料包含生物活性蛋白CD 39，一种降解ADP的酶，因此可能抑制血小板活化。正在狒狒动静脉分流模型中评价候选生物材料。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The goal of this project is to develop and evaluate blood contacting biomaterials that incorporate the bioactive protein, CD39, an enzyme that degrades ADP and therefore may inhibit platelet activation. Candidate biomaterials are being evaluated in the baboon arteriovenous shunt model.