PHARMACODYNAMIC EFFECTS OF ANT-SENSE

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 本项目的目的是确定反义寡核苷酸减少狒狒凝血因子Xi产生的药效学抗血栓形成作用。 皮下注射反义因子Xi，每周两次，持续1个月，现已显示在狒狒动静脉分流血栓形成模型中延长凝血时间并减少血栓传播。 这种治疗策略有可能产生有效但更安全的抗血栓治疗。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The goal of this project is to determine the pharmacodynamic anti-thrombotic effects of anti-sense oligonucleotides for reducing the production of coagulation factor XI in baboons. Subcutaneous administration of anti-sense factor XI, twice weekly for 1 month, has now been shown to prolong clotting times and reduce thrombus propagation in a baboon arteriovenous shunt thrombosis model. This treatment strategy has the potential to produce effective yet safer antithrombotic therapy.