EVALUATION OF NOVEL COATING OF METAL OXIDES IN A BABOON ARTERIO-VENOUS SHUNT MOD

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 本项目将在动静脉分流模型中评估新型金属氧化物涂层上血栓的形成。该模型已被广泛应用于人工表面和心血管装置的评估，并被证明在量化血栓在表面的发展和生长方面具有良好的重复性。在涉及血小板和血浆凝血因子的分子激活和抑制途径方面，狒狒与人类非常相似，因此在这些材料的临床前评估中发挥着重要作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project will evaluate thrombus formation on novel coatings for metal oxides in the arterio-venous baboon shunt model. This model has been used extensively in the evaluation of artificial surfaces and cardiovascular devices and has proven to be advantageous in its reproducibility in quantifying thrombus development and growth on surfaces. The baboon closely resemble humans with respect to molecular activation and inhibitory pathways involving platelets and plasma coagulation factors and therefore serve an important role in pre-clinical evaluation of these materials.