VECTOR-BORNE DISEASES CORE
媒介传播疾病核心
基本信息
- 批准号:8358066
- 负责人:
- 金额:$ 3.72万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-05-01 至 2012-04-30
- 项目状态:已结题
- 来源:
- 关键词:AdultAffectAnopheles GenusBlack-legged TickBloodBlood capillariesBorrelia burgdorferiCollaborationsDevelopmentEnsureFemaleFundingFutureGrantHealth SciencesHumanImmersion Investigative TechniqueImmune responseInfectionLarvaLiquid substanceLyme DiseaseMacaca mulattaModelingMoltingMusNational Center for Research ResourcesNymphOrder SpirochaetalesPlasmodium cynomolgiPrimatesPrincipal InvestigatorResearchResearch InfrastructureResourcesSourceSpecimenStagingTechniquesTexasTicksTimeUnited States National Institutes of HealthUniversitiesVirulenceVivax Malariacapillarycosteggfeedingresearch studytissue culture
项目摘要
This subproject is one of many research subprojects utilizing the resources
provided by a Center grant funded by NIH/NCRR. Primary support for the subproject
and the subproject's principal investigator may have been provided by other sources,
including other NIH sources. The Total Cost listed for the subproject likely
represents the estimated amount of Center infrastructure utilized by the subproject,
not direct funding provided by the NCRR grant to the subproject or subproject staff.
The VBD core has continued to maintain an Anopheles stephensi colony, which is used to transmit Plasmodium cynomolgi, a model of human vivax malaria, to rhesus macaques. The tick colony has continued to be instrumental in enabling our division to do research in Lyme borreliosis using the natural mode of infection. The technique of capillary feeding of nymphal ticks, which we have available, allows us to infect ticks with spirochetal clonal isolates. This is often essential to ensure defined host-responses to infection. We also are able to infect larval ticks by immersion in tissue-culture fluid that contains spirochetes. The tick section of the core has currently available numerous specimens of all of the developmental stages of Ixodes scapularis. Larvae, nymphs, and adults are stored at 4¿C in a staggered fashion. Therefore, we usually have all of the stages available at most times throughout the year. This includes 5-10 jars of larvae (with about 1000 larvae each) and several hundred uninfected nymphs for experimental needs as they arise. We have continued our collaboration with the University of Texas Health Sciences Center, Houston, TX, on the identification of virulence determinants of B. burgdorferi the affect infectivity of spirochetes to ticks, and to mice via ticks. This year 81 adult females were collected and were blood fed. A total of 51 of those fed successfully, and 36 of those laid eggs. The number of larvae that fed and were collected were 1982, and 1535 of those successfully molted into nymphs to be used in future experiments. A total of 497 nymphs were capillary-fed successfully. Those ticks were used in 3 large experiments. The remainder of the nymphs will be used in the current year.
这个子项目是利用资源的许多研究子项目之一。
由NIH/NCRR资助的中心拨款提供。对子项目的主要支持
子项目的首席调查员可能是由其他来源提供的,
包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能
表示该子项目使用的中心基础设施的估计数量,
不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。
VBD核心继续保持着一个斯氏按蚊群体,用于将食蟹猴疟原虫(一种人类间日疟的模型)传播给恒河猴。在使我们的部门能够利用自然感染模式对莱姆型疏螺旋体病进行研究方面,壁虱群体继续发挥着重要作用。我们现有的若虫毛细血管喂养技术,使我们能够用螺旋体克隆分离株感染壁虱。这通常是确保明确的宿主对感染的反应所必需的。我们也能够通过浸泡在含有螺旋体的组织培养液中感染幼虫。核心的扁虱部分目前有大量肩部硬蜱发育阶段的标本。幼虫、若虫和成虫以交错方式储存在4℃。因此,我们通常在一年中的大部分时间都有所有的舞台。这包括5-10瓶幼虫(每个约有1000只幼虫)和数百只未感染的若虫,以供实验需要。我们继续与德克萨斯州休斯敦的德克萨斯大学健康科学中心合作,确定伯氏杆菌的毒力决定因素,以影响螺旋体对扁虱和通过扁虱对小鼠的传染性。今年收集了81只成年雌性,并进行了血液喂养。总共有51只喂食成功,36只产卵。取食和采集的幼虫数量为1982头,其中1535头成功蜕皮成若虫,供未来实验使用。共成功喂食若虫497头。这些扁虱被用在三个大型实验中。其余的仙女将在本年度使用。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
MARIO TOMAS PHILIPP其他文献
MARIO TOMAS PHILIPP的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('MARIO TOMAS PHILIPP', 18)}}的其他基金
PATHOGENESIS OF LYME NEUROBORRELIOSIS: STUDIES EX VIVO & IN VIVO
莱姆病神经疏螺旋体病的发病机制:离体研究
- 批准号:
8358068 - 财政年份:2011
- 资助金额:
$ 3.72万 - 项目类别:
A RHESUS MACAQUE MODEL OF STREPTOCOCCUS PNEUMONIAE CARRIAGE
肺炎链球菌携带的恒河猴模型
- 批准号:
8358165 - 财政年份:2011
- 资助金额:
$ 3.72万 - 项目类别:
PATHOGENESIS OF LYME NEUROBORRELIOSIS IN THE RHESUS MONKEY: STUDIES IN VITRO
恒河猴莱姆病神经疏螺旋体病的发病机制:体外研究
- 批准号:
8358082 - 财政年份:2011
- 资助金额:
$ 3.72万 - 项目类别:
TICK SALIVA INHIBITS INFLAMMATION IN MONOCYTES STIMULATED WITH B BURGDORFERI
蜱唾液抑制布氏 B 氏菌刺激的单核细胞炎症
- 批准号:
8358087 - 财政年份:2011
- 资助金额:
$ 3.72万 - 项目类别:
TICK SALIVA INHIBITS INFLAMMATION IN MONOCYTES STIMULATED WITH B BURGDORFERI
蜱唾液抑制布氏 B 氏菌刺激的单核细胞炎症
- 批准号:
8172987 - 财政年份:2010
- 资助金额:
$ 3.72万 - 项目类别:
PATHOGENESIS OF LYME NEUROBORRELIOSIS IN THE RHESUS MONKEY: STUDIES IN VITRO
恒河猴莱姆病神经疏螺旋体病的发病机制:体外研究
- 批准号:
8172979 - 财政年份:2010
- 资助金额:
$ 3.72万 - 项目类别:
CHARACTERIZATION OF A MORAXELLA SPECIES THAT CAUSES EPSTAXIS IN MACAQUES
导致猕猴腹泻的莫拉氏菌属物种的特征
- 批准号:
8173026 - 财政年份:2010
- 资助金额:
$ 3.72万 - 项目类别:
相似海外基金
How Does Particle Material Properties Insoluble and Partially Soluble Affect Sensory Perception Of Fat based Products
不溶性和部分可溶的颗粒材料特性如何影响脂肪基产品的感官知觉
- 批准号:
BB/Z514391/1 - 财政年份:2024
- 资助金额:
$ 3.72万 - 项目类别:
Training Grant
BRC-BIO: Establishing Astrangia poculata as a study system to understand how multi-partner symbiotic interactions affect pathogen response in cnidarians
BRC-BIO:建立 Astrangia poculata 作为研究系统,以了解多伙伴共生相互作用如何影响刺胞动物的病原体反应
- 批准号:
2312555 - 财政年份:2024
- 资助金额:
$ 3.72万 - 项目类别:
Standard Grant
RII Track-4:NSF: From the Ground Up to the Air Above Coastal Dunes: How Groundwater and Evaporation Affect the Mechanism of Wind Erosion
RII Track-4:NSF:从地面到沿海沙丘上方的空气:地下水和蒸发如何影响风蚀机制
- 批准号:
2327346 - 财政年份:2024
- 资助金额:
$ 3.72万 - 项目类别:
Standard Grant
Graduating in Austerity: Do Welfare Cuts Affect the Career Path of University Students?
紧缩毕业:福利削减会影响大学生的职业道路吗?
- 批准号:
ES/Z502595/1 - 财政年份:2024
- 资助金额:
$ 3.72万 - 项目类别:
Fellowship
Insecure lives and the policy disconnect: How multiple insecurities affect Levelling Up and what joined-up policy can do to help
不安全的生活和政策脱节:多种不安全因素如何影响升级以及联合政策可以提供哪些帮助
- 批准号:
ES/Z000149/1 - 财政年份:2024
- 资助金额:
$ 3.72万 - 项目类别:
Research Grant
感性個人差指標 Affect-X の構築とビスポークAIサービスの基盤確立
建立个人敏感度指数 Affect-X 并为定制人工智能服务奠定基础
- 批准号:
23K24936 - 财政年份:2024
- 资助金额:
$ 3.72万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
How does metal binding affect the function of proteins targeted by a devastating pathogen of cereal crops?
金属结合如何影响谷类作物毁灭性病原体靶向的蛋白质的功能?
- 批准号:
2901648 - 财政年份:2024
- 资助金额:
$ 3.72万 - 项目类别:
Studentship
Investigating how double-negative T cells affect anti-leukemic and GvHD-inducing activities of conventional T cells
研究双阴性 T 细胞如何影响传统 T 细胞的抗白血病和 GvHD 诱导活性
- 批准号:
488039 - 财政年份:2023
- 资助金额:
$ 3.72万 - 项目类别:
Operating Grants
New Tendencies of French Film Theory: Representation, Body, Affect
法国电影理论新动向:再现、身体、情感
- 批准号:
23K00129 - 财政年份:2023
- 资助金额:
$ 3.72万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
The Protruding Void: Mystical Affect in Samuel Beckett's Prose
突出的虚空:塞缪尔·贝克特散文中的神秘影响
- 批准号:
2883985 - 财政年份:2023
- 资助金额:
$ 3.72万 - 项目类别:
Studentship