VECTOR-BORNE DISEASES CORE

媒介传播疾病核心

基本信息

  • 批准号:
    8358066
  • 负责人:
  • 金额:
    $ 3.72万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2011
  • 资助国家:
    美国
  • 起止时间:
    2011-05-01 至 2012-04-30
  • 项目状态:
    已结题

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The VBD core has continued to maintain an Anopheles stephensi colony, which is used to transmit Plasmodium cynomolgi, a model of human vivax malaria, to rhesus macaques. The tick colony has continued to be instrumental in enabling our division to do research in Lyme borreliosis using the natural mode of infection. The technique of capillary feeding of nymphal ticks, which we have available, allows us to infect ticks with spirochetal clonal isolates. This is often essential to ensure defined host-responses to infection. We also are able to infect larval ticks by immersion in tissue-culture fluid that contains spirochetes. The tick section of the core has currently available numerous specimens of all of the developmental stages of Ixodes scapularis. Larvae, nymphs, and adults are stored at 4¿C in a staggered fashion. Therefore, we usually have all of the stages available at most times throughout the year. This includes 5-10 jars of larvae (with about 1000 larvae each) and several hundred uninfected nymphs for experimental needs as they arise. We have continued our collaboration with the University of Texas Health Sciences Center, Houston, TX, on the identification of virulence determinants of B. burgdorferi the affect infectivity of spirochetes to ticks, and to mice via ticks. This year 81 adult females were collected and were blood fed. A total of 51 of those fed successfully, and 36 of those laid eggs. The number of larvae that fed and were collected were 1982, and 1535 of those successfully molted into nymphs to be used in future experiments. A total of 497 nymphs were capillary-fed successfully. Those ticks were used in 3 large experiments. The remainder of the nymphs will be used in the current year.
这个子项目是利用这些资源的众多研究子项目之一

项目成果

期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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MARIO TOMAS PHILIPP其他文献

MARIO TOMAS PHILIPP的其他文献

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{{ truncateString('MARIO TOMAS PHILIPP', 18)}}的其他基金

PATHOGENESIS OF LYME NEUROBORRELIOSIS: STUDIES EX VIVO & IN VIVO
莱姆病神经疏螺旋体病的发病机制:离体研究
  • 批准号:
    8358068
  • 财政年份:
    2011
  • 资助金额:
    $ 3.72万
  • 项目类别:
A RHESUS MACAQUE MODEL OF STREPTOCOCCUS PNEUMONIAE CARRIAGE
肺炎链球菌携带的恒河猴模型
  • 批准号:
    8358165
  • 财政年份:
    2011
  • 资助金额:
    $ 3.72万
  • 项目类别:
PATHOGENESIS OF LYME NEUROBORRELIOSIS IN THE RHESUS MONKEY: STUDIES IN VITRO
恒河猴莱姆病神经疏螺旋体病的发病机制:体外研究
  • 批准号:
    8358082
  • 财政年份:
    2011
  • 资助金额:
    $ 3.72万
  • 项目类别:
DIAGNOSTIC PARASITOLOGY CORE
诊断寄生虫学核心
  • 批准号:
    8358067
  • 财政年份:
    2011
  • 资助金额:
    $ 3.72万
  • 项目类别:
TICK SALIVA INHIBITS INFLAMMATION IN MONOCYTES STIMULATED WITH B BURGDORFERI
蜱唾液抑制布氏 B 氏菌刺激的单核细胞炎症
  • 批准号:
    8358087
  • 财政年份:
    2011
  • 资助金额:
    $ 3.72万
  • 项目类别:
TICK SALIVA INHIBITS INFLAMMATION IN MONOCYTES STIMULATED WITH B BURGDORFERI
蜱唾液抑制布氏 B 氏菌刺激的单核细胞炎症
  • 批准号:
    8172987
  • 财政年份:
    2010
  • 资助金额:
    $ 3.72万
  • 项目类别:
VECTOR-BORNE DISEASES CORE
媒介传播疾病核心
  • 批准号:
    8172960
  • 财政年份:
    2010
  • 资助金额:
    $ 3.72万
  • 项目类别:
PATHOGENESIS OF LYME NEUROBORRELIOSIS IN THE RHESUS MONKEY: STUDIES IN VITRO
恒河猴莱姆病神经疏螺旋体病的发病机制:体外研究
  • 批准号:
    8172979
  • 财政年份:
    2010
  • 资助金额:
    $ 3.72万
  • 项目类别:
DIAGNOSTIC PARASITOLOGY CORE
诊断寄生虫学核心
  • 批准号:
    8172961
  • 财政年份:
    2010
  • 资助金额:
    $ 3.72万
  • 项目类别:
CHARACTERIZATION OF A MORAXELLA SPECIES THAT CAUSES EPSTAXIS IN MACAQUES
导致猕猴腹泻的莫拉氏菌属物种的特征
  • 批准号:
    8173026
  • 财政年份:
    2010
  • 资助金额:
    $ 3.72万
  • 项目类别:

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