CALORIC RESTRICTION AND AGING IN NONHUMAN PRIMATE EYES

非人类灵长类动物眼睛的热量限制和衰老

• 批准号: 8357752
• 负责人: MARTHA NEURINGER
• 金额: $ 3.63万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357752
• 关键词: Address; Age; Aging; Atrophic; Caloric Restriction; Cataract; Cell physiology; Clinical; Development; Diet; Disease; Evaluation; Eye; Fishes; Funding; Glaucoma; Goals; Grant; Health; Human; Institutes; Intervention; Longevity; Macaca mulatta; Macular degeneration; Modeling; Monitor; Monkeys; National Center for Research Resources; Optic Nerve; Organ; Oxidative Stress; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Retinal Diseases; Rodent; Source; United States National Institutes of Health; age related; cost; fly; insight; nonhuman primate

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Dietary caloric restriction (CR) is the only intervention to reliably extend the lifespan of a variety of species, including worms, flies, fishes and rodents. Whether CR can also extend the human lifespan remains unknown. The National Institutes of Aging's Caloric Restriction Study maintains long-term colonies of nonhuman primates that are evaluated for many health parameters and markers of aging and provide the best available nonhuman primate model to address this question. As part of this unique resource, groups of rhesus monkeys, including young and old groups on 30% calorically restricted or ad libitum diets, were maintained at ONPRC for 4.5 years, and large groups are being followed throughout their lifespan at NIA. Because of its accessibility to noninvasive monitoring, the eye is an ideal organ to evaluate longitudinally whether CR can retard the occurrence of aging and age-related disease, and therefore we are conducting in-depth studies of ocular aging in these monkeys. The two major goals of our project are: 1) to determine whether CR retards the development of aging and age-related ocular diseases including macular degeneration, cataract, glaucoma and optic nerve atrophy; and 2) to correlate clinical observations with histopathological studies, using markers of age-related degeneration and oxidative stress. This research can provide new insights into the causes and possible treatment of human age-related ocular disorders. In the past year we continued evaluation of monkeys in the NIA CR colony, and completed morphological studies that contribute to understanding the cellular processes involved in age-related retinal disease.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 饮食热量限制（CR）是可靠地延长各种物种寿命的唯一干预措施，包括蠕虫，苍蝇，鱼类和啮齿动物。CR是否也可以延长人类寿命仍然未知。美国国立老龄化研究所的热量限制研究维持了非人类灵长类动物的长期群体，这些灵长类动物被评估了许多健康参数和衰老标志物，并提供了最好的非人类灵长类动物模型来解决这个问题。作为这一独特资源的一部分，恒河猴群体，包括30%热量限制或随意饮食的年轻和老年群体，在ONPRC维持了4.5年，并且在NIA的整个生命周期中对大群体进行了跟踪。由于其无创监测的可及性，眼睛是纵向评估CR是否可以延缓衰老和年龄相关疾病发生的理想器官，因此我们正在这些猴子中进行眼睛衰老的深入研究。我们项目的两个主要目标是：1）确定CR是否延缓衰老和年龄相关性眼病（包括黄斑变性、白内障、青光眼和视神经萎缩）的发展; 2）使用年龄相关性变性和氧化应激的标志物，将临床观察与组织病理学研究相关联。这项研究可以为人类年龄相关性眼部疾病的原因和可能的治疗提供新的见解。 在过去的一年中，我们继续评估NIA CR群体中的猴子，并完成了有助于理解年龄相关性视网膜疾病所涉及的细胞过程的形态学研究。