PROJECT 2 TENOFOVIR

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 在这项合作协议中，一种新型的局部杀菌剂阴道涂膜给药系统将与阴道凝胶制剂进行比较。我们将使用我们的猕猴模型来评估含有替诺福韦和/或达匹韦林的各种膜剂的安全性、分散性和药代动力学特性，并将这些结果与凝胶配方汇编的结果进行比较。这些研究将在一定程度上指导联合局部杀微生物剂递送系统的优化。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. In this cooperative agreement, a novel delivery system for topical microbicides, vaginal films, will be compared to vaginal gel formulations. We will use our macaque model to assess safety, dispersal and pharmacokinetic characteristics of various film formulations containing tenofovir and/or dapivirine, and compare these findings to those compiled for gel formulations. These studies will in part guide the optimization of a combination topical microbicide delivery system.