PROJECT 2 TENOFOVIR

项目 2 替诺福韦

• 批准号: 8357634
• 负责人: DOROTHY L PATTON
• 金额: $ 37.79万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357634
• 关键词: Drug Formulations; Film; Funding; Gel; Grant; Local Microbicides; Macaca; Modeling; National Center for Research Resources; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Safety; Source; System; TMC120-R147681; Tenofovir; U-Series Cooperative Agreements; United States National Institutes of Health; Vagina; Vaginal Gel; cost; novel; pharmacokinetic characteristic

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. In this cooperative agreement, a novel delivery system for topical microbicides, vaginal films, will be compared to vaginal gel formulations. We will use our macaque model to assess safety, dispersal and pharmacokinetic characteristics of various film formulations containing tenofovir and/or dapivirine, and compare these findings to those compiled for gel formulations. These studies will in part guide the optimization of a combination topical microbicide delivery system.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 在这项合作协议中，一种新的局部杀微生物剂的递送系统，阴道膜，将与阴道凝胶制剂进行比较。 我们将使用我们的猕猴模型来评估各种含有替诺福韦和/或达匹韦林的薄膜制剂的安全性、分散性和药代动力学特征，并将这些结果与凝胶制剂的结果进行比较。这些研究将部分指导组合局部杀微生物剂递送系统的优化。