PROJECT 2 TENOFOVIR

项目 2 替诺福韦

• 批准号: 8357634
• 负责人: DOROTHY L PATTON
• 金额: $ 37.79万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357634
• 关键词: Drug Formulations; Film; Funding; Gel; Grant; Local Microbicides; Macaca; Modeling; National Center for Research Resources; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Safety; Source; System; TMC120-R147681; Tenofovir; U-Series Cooperative Agreements; United States National Institutes of Health; Vagina; Vaginal Gel; cost; novel; pharmacokinetic characteristic

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. In this cooperative agreement, a novel delivery system for topical microbicides, vaginal films, will be compared to vaginal gel formulations. We will use our macaque model to assess safety, dispersal and pharmacokinetic characteristics of various film formulations containing tenofovir and/or dapivirine, and compare these findings to those compiled for gel formulations. These studies will in part guide the optimization of a combination topical microbicide delivery system.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 在这一合作协议中，将比较一种新型局部菌皮胶片，阴道膜的递送系统，将其与阴道凝胶配方进行比较。 我们将使用猕猴模型来评估包含替诺福韦和/或dapivirine的各种膜配方的安全性，分散和药代动力学特征，并将这些发现与为凝胶配方编译的发现进行比较。这些研究将部分指导组合局部菌心递送系统的优化。