CHLAMYDIA VACCINE STUDIES IN THE PIGTAIL MACAQUE

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 该项目的长期目标是探索针对衣原体感染的候选疫苗的有效性。沙眼衣原体是一种常见的性传播疾病，基本上没有症状，可进展为不孕不育，并与包括艾滋病毒在内的其他性传播疾病的感染有关。这项研究的初始阶段将集中于确定适当的阳性对照，以便在未来将在猕猴模型中进行的临床前疫苗研究中使用。在确定适当的阳性对照后，将以三至四臂研究设计(试验产品；阳性对照；阴性对照；佐剂对照)进行进一步研究，其中可开发疫苗产品以预防衣原体感染和随后的后遗症。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The long-term goal of this project is to explore the efficacy of vaccine candidates targeting chlamydial infection. Chlamydia trachomatis is a common sexually transmitted disease which is largely asymptomatic, can progress to infertility and has been associated with the facilitated acquisition of other STIs including HIV. The initial phases of this study will focus on determining an appropriate positive control to utilize in future preclinical vaccine studies to be carried out in the macaque model. With the determination of an appropriate positive control, further studies will be conducted in three- to four-arm study designs (test product; positive control; negative control; adjuvant control), where vaccine products can be developed to prevent chlamydial infection and subsequent sequelae.