CHLAMYDIA VACCINE STUDIES IN THE PIGTAIL MACAQUE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 该项目的长期目标是探索针对衣原体感染的候选疫苗的有效性。沙眼衣原体是一种常见的性传播疾病，基本上没有症状，可进展为不孕不育，并与包括艾滋病毒在内的其他性传播疾病的感染有关。这项研究的初始阶段将集中于确定适当的阳性对照，以便在未来将在猕猴模型中进行的临床前疫苗研究中使用。在确定适当的阳性对照后，将以三至四臂研究设计(试验产品；阳性对照；阴性对照；佐剂对照)进行进一步研究，其中可开发疫苗产品以预防衣原体感染和随后的后遗症。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The long-term goal of this project is to explore the efficacy of vaccine candidates targeting chlamydial infection. Chlamydia trachomatis is a common sexually transmitted disease which is largely asymptomatic, can progress to infertility and has been associated with the facilitated acquisition of other STIs including HIV. The initial phases of this study will focus on determining an appropriate positive control to utilize in future preclinical vaccine studies to be carried out in the macaque model. With the determination of an appropriate positive control, further studies will be conducted in three- to four-arm study designs (test product; positive control; negative control; adjuvant control), where vaccine products can be developed to prevent chlamydial infection and subsequent sequelae.