TRACE AMINE-ASSOCIATED RECEPTOR 1 IS A MODULATOR OF BRAIN MONOAMINERGIC SYSTEMS

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 由于人类和啮齿动物的示踪胺受体在结构、亚型数量和脑分布上存在差异，我们推测非人类灵长类动物将为揭示示踪胺亚型的生理和药理相关性提供更合适的模型。在这方面，非人灵长类和人类的痕量胺相关受体1(TAAR1)的序列有96%的同源性。我们正在使用药理学、细胞学、遗传学、解剖学、转基因和行为学的方法来研究TAAR1在哺乳动物大脑中的基本神经生物学作用以及它的激活或缺失所引起的行为影响。我们的研究为研究灵长类动物模型中痕量胺受体的生理和药理学相关性奠定了基础，并为开发治疗成瘾和神经精神障碍的药物提供了新的线索。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. As human and rodent trace amine receptors diverge in structure, subtype number and brain distribution, we postulate that non-human primates will provide a more suitable model for uncovering the physiological and pharmacological relevance of trace amine subtypes. In this regard, there is a 96 percent sequence identity for Trace Amine Associated Receptor 1 (TAAR1) in non-human primate and human. We are investigating the fundamental neurobiological roles of TAAR1 in mammalian brain and behavioral effects resulting from its activation or deletion using pharmacological, cellular, genetic, anatomical, transgenic and behavioral approaches. Our studies form the basis for investigating the physiological and pharmacological relevance of trace amine receptors in the primate model, and provide novel leads for developing therapeutic agents to treat addiction and neuropsychiatric disorders.