CENTRAL REGULATION OF SYMPATHETIC ACTIVITY TO BROWN FAT

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 平衡能量消耗与能量摄入、代谢需求和能量储存对于保持体重、对葡萄糖、胰岛素和瘦素等代谢信号的持续反应以及对许多身体系统的动态平衡调节至关重要。我们的实验正在定义和检验这样一个假设，即蝙蝠的能量消耗是消耗多余能量摄入的潜在汇，以防止白色脂肪组织中过度储存能量。明确能量传入信号通路，以及控制蝙蝠能量消耗效应的传出神经通路，将有助于我们理解体重和能量底物可用性的调节，并有助于设计治疗策略，以控制导致肥胖、糖尿病和高血压等疾病的身体能量平衡失调。最近的发现包括延髓腹外侧区的神经元对蝙蝠交感神经流出具有强大的交感神经抑制作用，以及将神经肽Y应用于苍白球吻部可引起蝙蝠交感神经活动和蝙蝠产热和体温升高的有力兴奋。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Balancing energy expenditure with energy intake, metabolic requirements and energy storage is critical for maintenance of body weight, for sustained responsiveness to metabolic signals such as glucose, insulin and leptin and for homeostatic regulation of many body systems. Our experiments are defining and testing the hypothesis that energy expenditure in BAT is a potential sink for the consumption of surplus energy intake to prevent excess energy storage in white adipose tissue. Defining energy afferent signaling pathways, as well as those efferent neural pathways controlling the BAT energy expenditure effector will contribute to our understanding of the regulation of body weight and of energy substrate availability and to the design of therapeutic strategies to control disturbances in body energy homeostasis that result in diseases such as obesity, diabetes and hypertension. Recent findings include the identification of neurons in the ventrolateral medulla as having a potent sympathoinhibitory effect on BAT sympathetic outflow and the demonstration that application of neuropeptide Y into the rostral raphe pallidus elicits a potent excitation of BAT sympathetic nerve activity and BAT thermogenesis and increases in body temperature.