CENTRAL REGULATION OF SYMPATHETIC ACTIVITY TO BROWN FAT

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 平衡能量消耗与能量摄入、代谢需求和能量储存对于维持体重、对于对代谢信号如葡萄糖、胰岛素和瘦素的持续响应以及对于许多身体系统的稳态调节是至关重要的。我们的实验是定义和测试的假设，在BAT的能量消耗是一个潜在的水槽消耗多余的能量摄入，以防止多余的能量储存在白色脂肪组织。定义能量传入信号通路以及控制BAT能量消耗效应器的传出神经通路将有助于我们理解体重和能量底物可用性的调节，并有助于设计治疗策略以控制导致肥胖、糖尿病和高血压等疾病的身体能量稳态紊乱。 最近的研究结果包括识别不同的预测，从视前区背内侧下丘脑和中缝苍白球，表征的抑制性影响BAT从下丘脑室旁神经元和脊髓5-羟色胺释放的显着作用的确定冷却诱发的增加BAT产热和能量消耗。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Balancing energy expenditure with energy intake, metabolic requirements and energy storage is critical for maintenance of body weight, for sustained responsiveness to metabolic signals such as glucose, insulin and leptin and for homeostatic regulation of many body systems. Our experiments are defining and testing the hypothesis that energy expenditure in BAT is a potential sink for the consumption of surplus energy intake to prevent excess energy storage in white adipose tissue. Defining energy afferent signaling pathways, as well as those efferent neural pathways controlling the BAT energy expenditure effector will contribute to our understanding of the regulation of body weight and of energy substrate availability and to the design of therapeutic strategies to control disturbances in body energy homeostasis that result in diseases such as obesity, diabetes and hypertension. Recent findings include the identification of distinct projections from the preoptic area to the dorsomedial hypothalamus and to the raphe pallidus, the characterization of an inhibitory influence on BAT from paraventricular hypothalamic neurons and the determination of a prominent role for spinal serotonin release in the cooling-evoked increase in BAT thermogenesis and energy expenditure.