TISSUE RESERVOIRS IN SIV-INFECTED LONG TERM NONPROGRESSORS
TISSUE RESERVOIRS IN SIV-INFECTED LONG TERM NONPROGRESSORS
批准号:
8358168
负责人:
Binhua Julie Ling
金额:
$5.78万
依托单位国家:
美国
项目类别:
财政年份:
2011
资助国家:
美国
项目状态:
已结题
起止时间:
2011-05-01 至 2012-04-30
关键词:
AnimalsBiological AssayCCR5 geneCD4 Positive T LymphocytesCellsChinese PeopleColonFundingGastrointestinal tract structureGrantHIVImmuneInfectionIntestinal MucosaMacaca mulattaMemoryModelingNational Center for Research ResourcesPlasmaPrimatesPrincipal InvestigatorProtease InhibitorRegimenResearchResearch InfrastructureResidual stateResourcesSIVSourceT-LymphocyteTestingTherapy EvaluationTissuesUnited States National Institutes of HealthViralViral Load resultantiretroviral therapycostimmune activationnonhuman primatepinacolyl methylphosphonic acidrestoration
中文摘要
这个子项目是利用这些资源的众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the resources
provided by a Center grant funded by NIH/NCRR. Primary support for the subproject
and the subproject's principal investigator may have been provided by other sources,
including other NIH sources. The Total Cost listed for the subproject likely
represents the estimated amount of Center infrastructure utilized by the subproject,
not direct funding provided by the NCRR grant to the subproject or subproject staff.
We have previously developed a SIV-infected Chinese rhesus macaque (ChRM) model for HIV-infected long-term nonprogressors (LTNP). By using this model, we have also demonstrated that the gastrointestinal tract, especially the colon, is a major reservoir for LTNP even when plasma viral load is undetectable by standard assay. We are using this model to further test the hypothesis that ChRM of SIV infection is a better model than other nonhuman primates for studies of tissue reservoirs on antiretroviral therapy, for evaluation of new strategies of viral eradication and immune restoration. Currently, we are conducting antiretroviral therapy (ART) in chronically SIV-infected ChRM. Animals were treated with PMPA/FTC and L-870812 daily for 2 months. Our results showed that plasma viral loads were reduced to 30 copies/ml in animals receiving ART. Immune activation of T cells in the gut was reduced in the first month of ART. Both jejunal and colonic mucosal memory CCR5+CD4+ T cells increased significantly and they were positively correlated during treatment. Moreover, restoration of these cells was inversely correlated with immune activation. Our studies indicate that combination ART is effective to suppress viral replication, reduce immune activation, and benefit to immune restoration in the gut. Further addition of protease inhibitors or other new regimens are to be evaluated if further reduction of residual viral replication and reservoir can be achieved in the intestinal mucosa.
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会议论文
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批准号:9560432
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项目类别:
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资助金额:$66.27万
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财政年份:2018
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CNS Myeloid Cells as SIV Reservoirs: Persistent Infection and Rebound
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批准号:10390435
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资助金额:$69.87万
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财政年份:2018
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CNS Myeloid Cells as SIV Reservoirs: Persistent Infection and Rebound
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批准号:10370645
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项目类别:
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资助金额:$70.86万
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财政年份:2018
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依托单位:
Eradication of latent SIV from the CNS
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批准号:10093149
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项目类别:
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资助金额:$67.24万
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财政年份:2017
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负责人:Binhua Julie Ling
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依托单位:
Eradication of latent SIV from the CNS
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批准号:9473820
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项目类别:
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资助金额:$78.75万
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财政年份:2017
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负责人:Binhua Julie Ling
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依托单位:
ROLE OF NK CELLS IN SIV-INFECTED LONG-TERM NONPROGRESSING RHESUS MACAQUES
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批准号:8358101
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项目类别:
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资助金额:$5.78万
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财政年份:2011
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负责人:Binhua Julie Ling
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依托单位:
Identification and eradication of HIV tissue reservoirs in a relevant animal mode
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批准号:8225153
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项目类别:
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资助金额:$81.28万
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财政年份:2011
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负责人:Binhua Julie Ling
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依托单位:
Identification and eradication of HIV tissue reservoirs in a relevant animal mode
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批准号:8418632
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项目类别:
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资助金额:$75.25万
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财政年份:2011
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负责人:Binhua Julie Ling
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依托单位:
Identification and eradication of HIV tissue reservoirs in a relevant animal mode
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批准号:8140734
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项目类别:
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资助金额:$83.02万
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财政年份:2011
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负责人:Binhua Julie Ling
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依托单位:
ROLE OF NK CELLS IN SIV-INFECTED LONG-TERM NONPROGRESSING RHESUS MACAQUES
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批准号:8173007
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项目类别:
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资助金额:$6.18万
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财政年份:2010
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负责人:Binhua Julie Ling
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依托单位:
RESERVOIRS IN THE INTESTINAL MUCOSA IN SIV-INFECTED LONG TERM NONPROGRESSORS
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批准号:8172981
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项目类别:
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资助金额:$6.18万
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财政年份:2010
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负责人:Binhua Julie Ling
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依托单位:
NK CELLS IN SIV-INFECTED LONG-TERM NONPROGRESSING RHESUS MACAQUES
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批准号:7958690
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项目类别:
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资助金额:$6.04万
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财政年份:2009
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负责人:Binhua Julie Ling
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依托单位:
IMMUNE RESTORATION AND PROTECTION IN SIV-INFECTED LONG TERM NONPROGRESSORS
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批准号:7960597
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项目类别:
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资助金额:$10.5万
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财政年份:2009
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负责人:Binhua Julie Ling
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依托单位:
IMMUNE RESTORATION AND PROTECTION IN SIV-INFECTED LONG TERM NONPROGRESSORS
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批准号:7958655
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项目类别:
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资助金额:$6.04万
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财政年份:2009
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负责人:Binhua Julie Ling
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依托单位:
IMMUNE RESTORATION AND PROTECTION IN SIV-INFECTED LONG TERM NONPROGRESSORS
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批准号:7720434
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项目类别:
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资助金额:$9.85万
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财政年份:2008
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负责人:Binhua Julie Ling
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依托单位:
LONGITUDINAL FOLLOW UP OF SIVMAC PATHOGENESIS IN MACAQUES OF CHINESE ORIGIN
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批准号:7716197
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项目类别:
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资助金额:$6.46万
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财政年份:2008
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负责人:Binhua Julie Ling
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依托单位:
IMMUNE RESTORATION AND PROTECTION IN SIV-INFECTED LONG TERM NONPROGRESSORS
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批准号:7716299
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项目类别:
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资助金额:$6.46万
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财政年份:2008
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负责人:Binhua Julie Ling
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依托单位:
RHESUS MACAQUE MODEL FOR GBV-C AND SIV CO-INFECTION
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批准号:7562351
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项目类别:
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资助金额:$3.29万
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财政年份:2007
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负责人:Binhua Julie Ling
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依托单位:
RESERVOIRS OF SIV IN LONG TERM NONPROGRESSORS IN RHESUS MACAQUES
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批准号:7562380
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项目类别:
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资助金额:$7.16万
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财政年份:2007
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负责人:Binhua Julie Ling
-
依托单位:
LONGITUDINAL FOLLOW UP OF SIVMAC PATHOGENESIS IN MACAQUES OF CHINESE ORIGIN
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批准号:7562259
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项目类别:
-
资助金额:$7.16万
-
财政年份:2007
-
负责人:Binhua Julie Ling
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依托单位:
海外基金