Paul Calabresi Career Development Award for Clinical Oncology (K12) at UC Davis

描述（由申请人提供）：加州大学戴维斯分校临床肿瘤研究职业发展计划（CDP）将培养初级教师学者成为独立的，以患者为导向的癌症研究人员。这些学者将进行转化研究，以开发实验室驱动的临床试验，旨在基于个体患者肿瘤或肿瘤类型的潜在分子特征优化新的治疗方法。CDP将培养具有不同背景的新教师，他们是团队科学的熟练领导者。加州大学戴维斯分校因其出色的患者护理，在培养下一代肿瘤学临床科学家方面处于有利地位；长期和资金充足的临床转化研究基础设施（包括癌症临床试验），包括nci指定的癌症中心和ncrr资助的临床和转化科学中心（CTSC）；有临床检验相关专业经验；在其他资源中，建立了机构间和机构内的联盟。在成功完成为期三年的核心课程后，学者将获得加州大学戴维斯分校癌症中心临床癌症研究证书。我们将结合关键的教学、研究和职业发展组成部分，在三年的课程中培养独立和富有成效的临床肿瘤学研究人员。我们将通过以下具体目标实现我们的目标：1)1)提供一个指导的，基于能力的教学课程，使学者能够整合基础，转化和临床科学知识，以发现和/或评估更有效的癌症治疗方法，从而改善患者的预后；2)根据每位CDP学者的兴趣和需求，监督个性化的面向患者的研究项目（研究者发起的临床试验）；3)监督CDP学者培训，以确保高质量“最终产品”的逐步发展：一个完全胜任的跨学科导向的临床医生科学家，可以成功地进行转化性癌症临床试验研究新药或设备。CDP的课程将以基础/转化科学和临床科学两个研究方向为指导。每个受训者都将获得适当的、综合的教学和“实践”指导的研究培训，遵循由两名独立资助的高级教师（一名基础/转化导师和一名临床导师）监督的计划，能够成功地解决其中一个方向的研究问题。我们在课程中加入了独特的团队科学和跨学科研究培训场所，以利用加州大学戴维斯分校其他培训项目的优势，特别是在CTSC内的培训项目。我们的总体目标是培养成功的、独立的临床癌症研究人员，他们将能够在团队中工作，开发和测试新的癌症治疗方法，基于他们对癌症生物学基础的复杂机制的理解，以及他们如何在个体患者和广泛人群中表现出疾病。因此，我们需要使临床医生精通实验室科学家的语言，反之亦然。我们的多学科方法在理解和开发肿瘤疾病靶向治疗方面的长期成功，关键取决于对新一代多学科研究人员的培训，他们拥有远远超出其最初学科界限的思想和技能。

DESCRIPTION (provided by applicant): The Clinical Oncology Research Career Development Program (CDP) at the University of California, Davis (UC Davis) will train junior faculty scholars to be independent, patient-oriented cancer researchers. The scholars will conduct translational research to develop laboratory-driven clinical trials designed to optimize novel therapeutic approaches based on the underlying molecular profiles of individual patient tumors or tumor types. The CDP will produce new faculty members from diverse backgrounds who are skilled leaders in team science. UC Davis is well-positioned to train the next generation of clinician scientists in oncology because of its outstanding patient care; long-standing and well-funded infrastructure in clinical-translational investigation (including cancer clinical trials), including our NCI-designated Cancer Center and NCRR-funded Clinical and Translational Science Center (CTSC); experience in laboratory-clinical correlative science; and established inter- and intra-institution consortia, among other resources. Upon successful completion of a three-year, salary-supported core curriculum, Scholars will receive a UC Davis Cancer Center Certificate in Clinical Cancer Research. We will combine key didactic, research, and career development components to produce independent and productive clinical oncology researchers over the course of a three-year program. We will accomplish our goals through the following specific aims: 1) 1) Offer a mentored, competency-based didactic curriculum so Scholars can integrate basic, translational, and clinical science knowledge to discover and/or evaluate more effective treatments for cancer that improve patient outcome; 2) Oversee individualized patient oriented research projects (investigator-initiated clinical trials) customized to the interests and needs of each CDP Scholar; and 3) Provide oversight of CDP Scholar training to ensure the progressive development of a high-quality "end-product": a fully competent interdisciplinary-oriented clinician scientist who can successfully conduct translational cancer clinical trials with investigational new agents or devices. The curriculum for the CDP will be guided by two research tracks in Basic/Translational and Clinical science. Each trainee will gain appropriate, integrated didactic and "hands-on" mentored research training following a plan supervised by two senior, independently funded faculty members (one Basic/Translational mentor and one Clinical mentor) to be able to successfully tackle research questions in one of these tracks. We have incorporated unique venues for training in team science and interdisciplinary research into the curriculum in order to take advantage of the strengths of other training programs at UC Davis, particularly those housed in the CTSC. Our overall goal is to develop successful, independent clinical cancer researchers who will be able to work in teams to develop and test new cancer treatments based upon their understanding of the complex mechanisms underlying cancer biology and how they manifest disease in individual patients as well as in broad populations. Thus, we need to make the clinician well-versed in the language of the laboratory scientist and vice-versa. The long-term success of our multidisciplinary approach to understanding and developing targeted treatments for oncologic disease critically depends upon the training of a new generation of multidisciplinary researchers who possess ideas and skills that go far beyond their initial disciplinary boundaries.