Paul Calabresi Career Development Award for Clinical Oncology (K12) at UC Davis

描述（由申请人提供）：加州大学戴维斯分校（UC Davis）的临床肿瘤学研究职业发展计划（CDP）将培训初级教师学者成为独立的，以患者为导向的癌症研究人员。学者们将进行转化研究，以开发实验室驱动的临床试验，旨在根据个体患者肿瘤或肿瘤类型的潜在分子谱优化新型治疗方法。CDP将培养来自不同背景的新教师，他们是团队科学的熟练领导者。加州大学戴维斯分校处于良好的地位，培养下一代临床科学家在肿瘤学，因为其出色的病人护理;长期和资金充足的基础设施，在临床转化研究（包括癌症临床试验），包括我们的NCI指定的癌症中心和NCRR资助的临床和转化科学中心（CTSC）;实验室-临床相关科学经验;并建立了机构间和机构内联合会等资源。在成功完成三年的工资支持的核心课程后，学者将获得加州大学戴维斯分校癌症中心临床癌症研究证书。我们将结合联合收割机关键的教学，研究和职业发展的组成部分，在三年的计划过程中产生独立和富有成效的临床肿瘤学研究人员。我们将通过以下具体目标来实现我们的目标：1）1）提供一个指导性的，基于能力的教学课程，使学者可以整合基础，翻译和临床科学知识，以发现和/或评估更有效的癌症治疗方法，改善患者的预后; 2）监督个性化的患者导向研究项目（由发起人发起的临床试验）根据每位CDP学者的兴趣和需求进行定制;以及3）监督CDP学者培训，以确保逐步开发高质量的“最终产品”：一个完全胜任的跨学科导向的临床科学家谁可以成功地进行转化癌症临床试验与研究新的代理或设备。CDP的课程将由基础/转化和临床科学的两个研究轨道指导。每个学员将获得适当的，综合的教学和“动手”指导的研究培训后，由两名高级，独立资助的教师（一个基本/翻译导师和一个临床导师）监督计划，能够成功地解决这些轨道之一的研究问题。我们已纳入团队科学和跨学科研究的培训课程的独特场所，以利用在加州大学戴维斯分校，特别是那些住在CTSC的其他培训计划的优势。我们的总体目标是培养成功的，独立的临床癌症研究人员，他们将能够在团队中工作，开发和测试新的癌症治疗方法，基于他们对癌症生物学的复杂机制的理解，以及他们如何在个体患者和广泛人群中表现出疾病。因此，我们需要使临床医生精通实验室科学家的语言，反之亦然。我们的多学科方法理解和开发肿瘤疾病的靶向治疗的长期成功关键取决于新一代多学科研究人员的培训，他们拥有远远超出其最初学科界限的想法和技能。

DESCRIPTION (provided by applicant): The Clinical Oncology Research Career Development Program (CDP) at the University of California, Davis (UC Davis) will train junior faculty scholars to be independent, patient-oriented cancer researchers. The scholars will conduct translational research to develop laboratory-driven clinical trials designed to optimize novel therapeutic approaches based on the underlying molecular profiles of individual patient tumors or tumor types. The CDP will produce new faculty members from diverse backgrounds who are skilled leaders in team science. UC Davis is well-positioned to train the next generation of clinician scientists in oncology because of its outstanding patient care; long-standing and well-funded infrastructure in clinical-translational investigation (including cancer clinical trials), including our NCI-designated Cancer Center and NCRR-funded Clinical and Translational Science Center (CTSC); experience in laboratory-clinical correlative science; and established inter- and intra-institution consortia, among other resources. Upon successful completion of a three-year, salary-supported core curriculum, Scholars will receive a UC Davis Cancer Center Certificate in Clinical Cancer Research. We will combine key didactic, research, and career development components to produce independent and productive clinical oncology researchers over the course of a three-year program. We will accomplish our goals through the following specific aims: 1) 1) Offer a mentored, competency-based didactic curriculum so Scholars can integrate basic, translational, and clinical science knowledge to discover and/or evaluate more effective treatments for cancer that improve patient outcome; 2) Oversee individualized patient oriented research projects (investigator-initiated clinical trials) customized to the interests and needs of each CDP Scholar; and 3) Provide oversight of CDP Scholar training to ensure the progressive development of a high-quality "end-product": a fully competent interdisciplinary-oriented clinician scientist who can successfully conduct translational cancer clinical trials with investigational new agents or devices. The curriculum for the CDP will be guided by two research tracks in Basic/Translational and Clinical science. Each trainee will gain appropriate, integrated didactic and "hands-on" mentored research training following a plan supervised by two senior, independently funded faculty members (one Basic/Translational mentor and one Clinical mentor) to be able to successfully tackle research questions in one of these tracks. We have incorporated unique venues for training in team science and interdisciplinary research into the curriculum in order to take advantage of the strengths of other training programs at UC Davis, particularly those housed in the CTSC. Our overall goal is to develop successful, independent clinical cancer researchers who will be able to work in teams to develop and test new cancer treatments based upon their understanding of the complex mechanisms underlying cancer biology and how they manifest disease in individual patients as well as in broad populations. Thus, we need to make the clinician well-versed in the language of the laboratory scientist and vice-versa. The long-term success of our multidisciplinary approach to understanding and developing targeted treatments for oncologic disease critically depends upon the training of a new generation of multidisciplinary researchers who possess ideas and skills that go far beyond their initial disciplinary boundaries.