CORE--Clinical Research Skills Development

我们建议在转化研究中建立一个新的教育项目，即临床研究技能 发展核心，以满足这些需求。我们早就认识到“团队方法”的重要性 通过整合基础科学家， 来自不同领域的临床科学家。除了在实验室和临床领域的成功，我们的 该计划进一步为许多年轻人提供了指导和职业发展的环境 临床科学家，包括我们目前的项目负责人，博士常春藤和Kinsella。最近，我们的NIH SCOR计划进一步成为正在进行的NIH T32儿科培训计划的重要资源 肺医学（Abman博士; PI）和心血管生物工程（Shandas博士; PI）。 因此，临床研究技能发展核心的总体目标是制定一个更正式的 儿童肺动脉高压的教育和培训计划，可以汇集优势 高度合作，多学科的研究人员，以扩大我们的能力，更好地培养年轻人， 临床科学家在转化研究。我们已经制定了一项计划，开发新的研讨会，讲习班和 培训方法，以疾病和病人为导向的研究，包括经验丰富的研究人员 来自不同的领域。随着遗传学和基因组学、蛋白质组学、结果研究和 相关领域，我们计划汇集我们机构内部和其他机构在这些领域的主要领导人， 学术健康中心这种方法反映在我们当前应用程序中概述的新项目中。为 例如，人类遗传学主任Richard Spritz博士和遗传学主任Jill Norris博士 流行病学，现在，第一次，积极参与其专业领域的应用， 小儿肺动脉高压问题（项目2）。此外，Crapo博士是项目的积极参与者， 4将可用于弥合氧化剂研究中的实验室到床边的差距。他们将与最近的K23 获奖者或申请人（Peter Zagani博士，医学博士和Marci Sontag博士），沿着其他高级临床科学家 在SCCOR计划中。临床研究技能发展核心的增加将提供一个 正式的结构，以加强互动和培训机会，这将导致高技能的临床 能够更好地将遗传学和遗传流行病学等多种技能应用于儿科的研究人员 肺血管疾病正如提案所述，我们计划提供严格的培训结构， 临床科学家与健康结果研究，临床试验设计，临床生理学， 生物信息学和其他领域。为进一步提升培训气氛，我们计划在 科学诚信和道德，沟通技巧，指导，职业发展和其他重要主题。 该计划将由Abman博士协调，他在指导和培训方面拥有丰富的经验 作为儿科心肺中心主任和NIH T32项目的PI， 药他将与Stenmark博士、项目负责人和合作科学家密切合作， 这个核心计划。

We propose to establish a new educational program in translational research, the Clinical Research Skills Development Core, to address these needs. We have long-recognized the importance of the "team approach" for attacking the clinical problem of pediatric pulmonary hypertension through the integration of basic scientists from diverse fields with clinician-scientists. In addition to successes in the laboratory and clinical arenas, our program has further provided the environment for mentoring and career development of numerous young clinician-scientists, including 2 of our current project leaders, Drs. Ivy and Kinsella. In the recent past, our NIH SCOR program has further served as an important resource for ongoing NIH T32 training programs in pediatric pulmonary medicine (Dr. Abman; PI) and cardiovascular bioengineering (Dr. Shandas; PI). Thus, the overall goal of the Clinical Research Skills Development Core is to develop a more formal educational and training program in pediatric pulmonary hypertension, which can bring together the strengths of highly collaborative, multidisciplinary investigators, in order to expand our ability to better train young clinician-scientists in translational research. We have outlined a plan to develop new seminars, workshops and training approaches to disease- and patient- oriented research that incorporates experienced investigators from diverse fields. With rapid advances in genetics and genomics, proteomics, outcomes research, and related fields, we plan to bring together major leaders in these fields from within our institution and from other academic health centers. This approach is reflected in the new projects outlined in our current application. For example, Dr. Richard Spritz, the Director of Human Genetics, and Dr. Jill Norris, Head of Genetic Epidemiology, are now, for the first time, actively engaged in the application of their areas of expertise to the problem of pediatric pulmonary hypertension (Project 2). In addition, Dr. Crapo, an active participant in Project 4 will be available to bridge the bench to bedside gap in oxidant research. They will be working with recent K23 awardees or applicants (Drs. Peter Mourani, MD, and Marci Sontag, PhD), along with other senior clinicianscientists in the SCCOR Program. The addition of the Clinical Research Skills Development Core will provide a formal structure to enhance interactions and training opportunities, which will lead to highly-skilled clinical investigators who can better apply numerous skills including genetics and genetic epidemiology to pediatric pulmonary vascular disease. As outlined in the proposal, we plan to provide rigorous training structure to bring together clinician-scientists with leaders in health outcomes research, clinical trial design, clinical physiology, bioinformatics and other fields. To further enhance the training atmosphere, we plan formal workshops in scientific integrity and ethics, communication skills, mentorship, career development, and other critical topics. This program will be co-ordinated by Dr. Abman, who has extensive experience with mentorship and training as Director of the Pediatric Heart Lung Center and the PI of the NIH T32 Program in pediatric pulmonary medicine. He will work closely with Dr. Stenmark, the Project Leaders and collaborating scientists to develop this Core program.