NHP Major Histocompatibility Complex Gene Discovery and Typing Technology

NHP主要组织相容性复合体基因发现和分型技术

• 批准号: 8335592
• 负责人: DANIEL E. GERAGHTY
• 金额: $ 581.53万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8335592
• 关键词: Alleles; Animal Experimentation; Area; Autoimmune Diseases; Basic Science; Cell Transplantation; Clinical Research; Communicable Diseases; Contracts; Development; Genetic; Genomics; Genotype; Goals; Graft Rejection; Human; Individual; Infectious Diseases Research; Knowledge; Macaca; Macaca fascicularis; Macaca mulatta; Major Histocompatibility Complex; Major Histocompatibility Complex Gene; Maps; Methods; Modeling; Organ Transplantation; Research; Techniques; Technology; Transplantation; Vaccines; design; gene discovery; graft vs host disease; nonhuman primate; research study; technology development; tool

The objectives of Nonhuman Primate Major Histocompatibility Complex Gene Discovery and Typing Technology Development are to facilitate and enhance the immunological research conducted with the nonhuman primate (NHP) model by providing detailed knowledge of NHP MHC genes, loci and alleles through gene discovery and genomic characterization studies; and by developing and providing readily accessible means or methods to genotype individual research animals for the complete set of MHC alleles, or for select alleles, for the optimum design of experiments and genetic management of colonies. A detailed map of the MHC region in NHPs will promote basic and clinical research of infectious diseases, vaccines, transplantation, and autoimmune diseases, and support the development of new tools and techniques in this area.

非人灵长类动物主要组织相容性复合体基因发现和分型技术开发的目标是通过基因发现和基因组表征研究提供NHP MHC基因、基因座和等位基因的详细知识，促进和加强用非人灵长类动物（NHP）模型进行的免疫学研究;以及通过开发和提供容易获得的手段或方法来对个体研究动物进行MHC等位基因的完整集合或选择等位基因的基因分型，用于实验的最佳设计和菌落的遗传管理。NHPs中MHC区域的详细图谱将促进传染病、疫苗、移植和自身免疫性疾病的基础和临床研究，并支持该领域新工具和技术的开发。