NHP MHC Gene Discovery and Typing Technology Development

NHP MHC 基因发现和分型技术开发

• 批准号: 8335590
• 负责人: DAVID O'CONNOR
• 金额: $ 656.98万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8335590
• 关键词: Alleles; Animal Experimentation; Area; Autoimmunity; Basic Science; Cell Transplantation; Clinical Research; Communicable Diseases; Communities; Contracts; Data; Databases; Development; Family suidae; Frequencies; Genetic; Genomics; Genotype; Graft Rejection; Human; Individual; Infectious Diseases Research; Knowledge; Macaca; Macaca fascicularis; Macaca mulatta; Macaca nemestrina; Major Histocompatibility Complex; Major Histocompatibility Complex Gene; Maps; Methods; Modeling; Organ Transplantation; Reagent; Research; Research Support; Tail; Techniques; Training; Transplantation; Vaccines; design; gene discovery; genotyping technology; graft vs host disease; nonhuman primate; novel; programs; research study; technology development; tool

The objectives of Nonhuman Primate Major Histocompatibility Complex Gene Discovery and Typing Technology Development are to facilitate and enhance the immunological research conducted with the nonhuman primate model by providing detailed knowledge of NHP MHC genes, loci and alleles through gene discovery and genomic characterization studies; and by developing and providing readily accessible means or methods to genotype individual research animals for the complete set of MHC alleles, or for select alleles, for the optimum design of experiments and genetic management of colonies. A detailed map of the MHC region in NHPs will promote basic and clinical research of infectious diseases, vaccines, transplantation, and autoimmunity, and support the development of new tools and techniques in this area.

非人灵长类动物主要组织相容性复合体基因发现和分型技术开发的目标是通过基因发现和基因组表征研究，提供NHP MHC基因、位点和等位基因的详细知识，促进和加强非人灵长类动物模型的免疫学研究；并通过开发和提供易于获得的手段或方法来对个体研究动物进行基因型，以获得完整的MHC等位基因，或选择等位基因，以优化实验设计和菌落遗传管理。国家卫生保健计划中MHC区域的详细地图将促进传染病、疫苗、移植和自身免疫的基础和临床研究，并支持该领域新工具和技术的开发。