FOLLOW-UP OF THE MULTIMODAL TREATMENT STUDY OF CHILDREN WITH ATTENTION DEFICIT H

注意力缺陷儿童多模式治疗研究的随访 H

• 批准号: 8256729
• 负责人: BROOKE S.G. MOLINA
• 金额: $ 44.15万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-28 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8256729
• 关键词: Accidents; Achievement; Address; Alcohol or Other Drugs use; Amphetamines; Anxiety; Attention; Attention deficit hyperactivity disorder; Behavior; Behavior Therapy; Behavioral Symptoms; Blood Pressure; Child; Child Rearing; Combined Modality Therapy; Communities; Comorbidity; Contracts; Control Groups; Data Collection; Disease; Dose; Eating Disorders; Educational Status; Effectiveness; Exposure to; Goals; Grant; Growth; Health; Heart Rate; Height; Incidence; Independent Living; Individual; Long-Term Effects; Mediation; Mediator of activation protein; Medical; Medication Management; Mental Depression; Mental Health; Mental disorders; Modality; National Institute of Mental Health; Occupational; Outcome; Participant; Pharmaceutical Preparations; Phase; Psychopathology; Psychotic Mood Disorders; Puberty; Randomized; Relative (related person); Research; Research Design; Research Personnel; Risk; Schools; Services; Site; Speed; Substance Addiction; Substance abuse problem; Support Contracts; Symptoms; Tic disorder; Time; U-Series Cooperative Agreements; adverse outcome; clinical research site; design; follow-up; psychosocial; psychotic mania; social; standard care; suicidal behavior; treatment as usual; treatment site

The purpose of this contract is to study the long-term effects of different treatment modalities for children with attention deficit hyperactivity disorder (ADHD) through a systematic follow-up of the subjects who participated in the Multimodal Treatment Study of Children with ADHD (MTA). The initial design and planning phase of the MTA study occurred during the latter portion of 1992 thru the end of 1993, where the divergent study designs and goals of the various investigators were blended into a cohesive, coherent, and scientifically rigorous final design. The 24-month MTA Study (14 months of treatment, followed by a 10-month follow-up assessment) of 579 children with ADHD was conducted at seven treatment sites over the course of the next four years. Participants were assessed before, during, and at the end of 14 months of treatment, and 10 months later. Treatment was received depending on to which one of four groups participants were randomized (medication alone, behavioral treatment alone, medication plus behavioral treatment, community treatment as usual). This five-year period was supported by NIMH cooperative agreement grants to the clinical sites. At the 24-month point, a Local Normative Control Group of grade- and school-matched non-patients was added as a comparator group. With the support of a subsequent competing supplement to each site, 36-month follow-up assessments were completed. The original MTA aims addressed the following questions: What are the differences in effectiveness for medication management versus intensive behavioral treatments? What are the additive/synergistic effects of combined medication and psychosocial treatment compared to either treatment delivered alone? What is the relative effectiveness of systematic, well-delivered treatments vs. ¿standard¿ treatments typically received in the community? Additional questions the MTA investigators sought to address included the prediction and mediation of treatment-related gains from individual (e.g., co-morbidity), familial (e.g., child-rearing practices), and/or social (e.g., SES) variables. This current contract supports assessment and data collection for follow-up year 12 of the MTA study, at the seven original sites. Each site is supported by an individual contract to that site.

本合同的目的是通过对参加ADHD儿童多模式治疗研究（MTA）的受试者进行系统随访，研究不同治疗方式对ADHD儿童的长期影响。MTA研究的初始设计和规划阶段发生在1992年下半年至1993年底，在此期间，不同研究者的不同研究设计和目标被融合成一个有凝聚力的、连贯的和科学严谨的最终设计。这项为期24个月的MTA研究（14个月的治疗，随后进行10个月的随访评估）对579名ADHD儿童进行了为期四年的研究。参与者在14个月的治疗之前，期间和结束时以及10个月后进行评估。根据参与者被随机分配到四组中的哪一组（单独药物治疗，单独行为治疗，药物加行为治疗，照常社区治疗）接受治疗。这五年期间得到了NIMH合作协议对临床研究中心的资助。在24个月时，增加了一个由年级和学校匹配的非患者组成的当地规范对照组作为对照组。在随后对每个研究中心的竞争性补充的支持下，完成了36个月的随访评估。 最初的MTA目标解决了以下问题：药物管理与强化行为治疗的有效性有何差异？与单独使用任何一种治疗相比，联合用药和心理社会治疗有哪些叠加/协同效应？系统的、良好的治疗与社区通常接受的标准治疗的相对有效性是多少？MTA研究人员寻求解决的其他问题包括预测和调解个人的治疗相关收益（例如，共病），家族性（例如，育儿实践），和/或社会（例如，SES）变量。 目前的合同支持在7个原始研究中心进行MTA研究第12年随访的评估和数据收集。每个站点都有与该站点的单独合同。