FOLLOW-UP OF THE MULTIMODAL TREATMENT STUDY OF CHILDREN WITH ATTENTION DEFICIT H

注意力缺陷儿童多模式治疗研究的随访 H

• 批准号: 8256731
• 负责人: TIM WIGAL
• 金额: $ 34.14万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-10 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8256731
• 关键词: Accidents; Achievement; Address; Alcohol or Other Drugs use; Amphetamines; Anxiety; Attention; Attention deficit hyperactivity disorder; Behavior; Behavior Therapy; Behavioral Symptoms; Blood Pressure; Child; Child Rearing; Combined Modality Therapy; Communities; Comorbidity; Contracts; Control Groups; Data Collection; Disease; Dose; Eating Disorders; Educational Status; Effectiveness; Exposure to; Goals; Grant; Growth; Health; Heart Rate; Height; Incidence; Independent Living; Individual; Long-Term Effects; Mediation; Mediator of activation protein; Medical; Medication Management; Mental Depression; Mental Health; Mental disorders; Modality; National Institute of Mental Health; Occupational; Outcome; Participant; Pharmaceutical Preparations; Phase; Psychopathology; Psychotic Mood Disorders; Puberty; Randomized; Relative (related person); Research; Research Design; Research Personnel; Risk; Schools; Services; Site; Speed; Substance Addiction; Substance abuse problem; Support Contracts; Symptoms; Tic disorder; Time; U-Series Cooperative Agreements; adverse outcome; clinical research site; design; follow-up; psychosocial; psychotic mania; social; standard care; suicidal behavior; treatment as usual; treatment site

The purpose of this contract is to study the long-term effects of different treatment modalities for children with attention deficit hyperactivity disorder (ADHD) through a systematic follow-up of the subjects who participated in the Multimodal Treatment Study of Children with ADHD (MTA). The initial design and planning phase of the MTA study occurred during the latter portion of 1992 thru the end of 1993, where the divergent study designs and goals of the various investigators were blended into a cohesive, coherent, and scientifically rigorous final design. The 24-month MTA Study (14 months of treatment, followed by a 10-month follow-up assessment) of 579 children with ADHD was conducted at seven treatment sites over the course of the next four years. Participants were assessed before, during, and at the end of 14 months of treatment, and 10 months later. Treatment was received depending on to which one of four groups participants were randomized (medication alone, behavioral treatment alone, medication plus behavioral treatment, community treatment as usual). This five-year period was supported by NIMH cooperative agreement grants to the clinical sites. At the 24-month point, a Local Normative Control Group of grade- and school-matched non-patients was added as a comparator group. With the support of a subsequent competing supplement to each site, 36-month follow-up assessments were completed. The original MTA aims addressed the following questions: What are the differences in effectiveness for medication management versus intensive behavioral treatments? What are the additive/synergistic effects of combined medication and psychosocial treatment compared to either treatment delivered alone? What is the relative effectiveness of systematic, well-delivered treatments vs. ¿standard¿ treatments typically received in the community? Additional questions the MTA investigators sought to address included the prediction and mediation of treatment-related gains from individual (e.g., co-morbidity), familial (e.g., child-rearing practices), and/or social (e.g., SES) variables. This current contract supports assessment and data collection for follow-up year 12 of the MTA study, at the seven original sites. Each site is supported by an individual contract to that site.

这份合同的目的是通过对参与多模式儿童多动症治疗研究(MTA)的受试者进行系统跟踪，研究不同治疗方式对儿童注意缺陷多动障碍(ADHD)的长期影响。MTA研究的初始设计和规划阶段发生在1992年下半年至1993年底，在这个阶段，不同研究人员的不同研究设计和目标被融合到一个连贯、连贯和科学严谨的最终设计中。在接下来的四年中，对579名ADHD儿童进行了为期24个月的MTA研究(14个月的治疗，随后10个月的跟踪评估)，在7个治疗地点进行。在14个月的治疗之前、期间和结束时，以及10个月后，对参与者进行评估。接受治疗取决于参与者被随机分到四组中的哪一组(单独药物治疗、单独行为治疗、药物加行为治疗、照常进行社区治疗)。这五年期间得到了NIMH对临床站点的合作协议赠款的支持。在24个月的时间点，增加了与年级和学校匹配的非患者的当地规范控制组作为对照组。在随后对每个地点进行的竞争性补充的支持下，完成了为期36个月的后续评估。 最初的MTA目标是解决以下问题：药物管理与强化行为治疗在有效性方面有什么不同？与单独使用任何一种治疗相比，联合用药和心理社会治疗的附加/协同效应是什么？与社区通常接受的标准治疗相比，系统的、提供良好的治疗的相对有效性是什么？MTA调查人员试图解决的其他问题包括个人(例如，共病)、家庭(例如，子女养育做法)和/或社会(例如，SES)变量对与治疗相关的收益的预测和调解。 目前的合同支持在7个原址进行中期技术援助研究第12年后续行动的评估和数据收集。每个站点都由该站点的单独合同提供支持。