Explosive Evolution Under Stress: The Driving Forces of Cancer Dynamics (Main)

压力下的爆炸性进化：癌症动力学的驱动力（主）

• 批准号: 8323592
• 负责人: Robert H. Austin
• 金额: $ 277.6万
• 依托单位: PRINCETON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-28 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8323592
• 关键词: Explosive; Evolution; Under; Stress; Driving

The re-emergence of resistant cancer cells after initial therapy is one of the great unsolved, and deadly, problems in oncology, and a fundamental problem of evolution under stress. This project is aimed at understanding, from general principles of physics, ecology, and biology, why recurrence of resistant cancer cells seems to be a universal phenomenon in cancer. We believe that evolution in small, stressed habitats is the key to the rapid and inevitable re-emergence of resistance. The physical technology that drives this Project uses microfabrication of tiny, stressed habitats to test these Ideas. Modern techniques of physical probes, genomics, proteomics and nanotechnology will allow us to analyze the evolutionary path of these emergent resistant cells.

初始治疗后耐药癌细胞的重新出现是肿瘤学中未解决的重大致命问题之一，也是压力下进化的基本问题。本项目旨在从物理学、生态学和生物学的一般原理出发，理解为什么耐药癌细胞的复发似乎是癌症中的普遍现象。我们相信，在小的、有压力的栖息地中的进化是快速和不可避免地重新出现抗性的关键。推动这个项目的物理技术使用微型制造的微小，强调栖息地来测试这些想法。物理探针、基因组学、蛋白质组学和纳米技术的现代技术将使我们能够分析这些新出现的抗性细胞的进化路径。