HPV Vaccination among Daughters of Latina Immigrants

拉丁裔移民的女儿接种 HPV 疫苗

• 批准号: 8345760
• 负责人: ISABEL C SCARINCI
• 金额: $ 20.68万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-20 至 2017-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8345760
• 关键词: 18 year old; 2 year old; Accounting; Address; Adenocarcinoma In Situ; Adolescent Risk Behavior; African American; Age; Age-Years; Alabama; Alaska Native; American Indians; Attitude; Behavior; Belief; Birth Rate; Censuses; Central America; Cervical; Cervical Adenocarcinoma; Cervical cancer vaccine; Coitus; Data; Daughter; Disease; Dose; Eating; Economic Burden; Education; Ethnic group; Evaluation; Goals; Growth; Health Benefit; Health behavior; Hispanics; Human Papilloma Virus Vaccine; Human Papillomavirus; Human papilloma virus infection; Human papillomavirus 6; Immigrant; Immigration; Incidence; Infection; Intervention; Investments; Knowledge; Latina; Latino; Malignant neoplasm of cervix uteri; Mexico; Minority; Mothers; Pap smear; Phase; Physical activity; Population; Prevention; Primary Prevention; Public Health; Randomized; Randomized Controlled Trials; Reporting; Research; South Carolina; Testing; Time; United States; Vaccinated; Vaccination; Vulva; Woman; base; comparison group; efficacy testing; experience; girls; health disparity; high risk; improved; minority health; mortality; novel strategies; prevent; primary outcome; racial and ethnic; secondary outcome; sexual debut; successful intervention; theories; therapy development; tool; uptake; vaginal intraepithelial neoplasia

Latinos are largest minority population in the U.S with a projected change of 144% of Latino girls between the ages of 10 and 14 in 2050 as compared to 39% projected change among whites. The 2010 U.S. Census indicated that the Latino population in Alabama grew 145%, which represents the second largest percentage growth between 2000 and 2010 in the U.S. after South Carolina. Cervical cancer incidence and mortality is higher among Latinas than among white women. Unless there is significant HPV vaccine uptake in this population the economic burden of evaluating abnormal Pap smears and/or treating invasive cervical cancer is likely to increase in the U.S. for the first time in decades. We propose a 5-year group randomized controlled trial (RCT) to test the efficacy of a theory-based culturally relevant intervention to promote HPV vaccine uptake among daughters of Latina immigrants between the ages of 9 and 12 with four specific aims: (1) To conduct a formative evaluation in order to develop theory-based, culturally relevant intervention to promote HPV vaccine uptake among daughters of Latina immigrants between the ages of 9 and 12; (2) To develop the proposed intervention based on the results of Aim 1 and previous pilot data; (3) To implement the intervention among 320 Latina immigrant mothers of daughters between 9 and 12; and (4) To evaluate the efficacy of such intervention through a group RCT. The comparison group will receive education on healthy eating and physical activity. The primary outcomes will be receipt of first dose as well as completion of all three doses of the HPV vaccine among daughters of Latina immigrants between the ages of 9 and 12. Secondary outcomes will include: changes in attitudes, and beliefs regarding HPV/cervical cancer and HPV vaccine among Latina immigrant mothers of daughters between the ages of 9 and 12. The proposed study addresses an important scientific knowledge gap since little is known about HPV vaccine uptake among daughters of Latina immigrants, a high risk group for HPV infection and cervical cancer. If proven successful, this intervention could be disseminated to daughters of Latina immigrants across the U.S. with the potential of having a major public health impact.

拉丁裔是美国最大的少数族裔人口，预计到 2050 年，10 岁至 14 岁之间的拉丁裔女孩的比例将发生 144% 的变化，而白人的比例预计将变化 39%。 2010年美国人口普查显示，阿拉巴马州的拉丁裔人口增长了145%，这是2000年至2010年间美国第二大的增长百分比，仅次于南卡罗来纳州。 拉丁裔女性的宫颈癌发病率和死亡率高于白人女性。除非该人群大量接种 HPV 疫苗，否则美国评估异常巴氏涂片和/或治疗浸润性宫颈癌的经济负担可能会出现数十年来的首次增加。我们提议进行一项为期 5 年的随机对照试验 (RCT)，以测试基于理论的文化相关干预措施对促进 9 至 12 岁拉丁裔移民的女儿接种 HPV 疫苗的有效性，其具体目标有四个：(1) 进行形成性评估，以制定基于理论、文化相关的干预措施，以促进 9 至 12 岁拉丁裔移民的女儿接种 HPV 疫苗。 9和12； (2) 根据目标 1 的结果和之前的试点数据制定拟议的干预措施； (3) 对320名女儿在9岁至12岁之间的拉丁裔移民母亲实施干预； (4) 通过团体随机对照试验评估此类干预的效果。对照组将接受健康饮食和体育活动的教育。主要结果将是 9 至 12 岁拉丁裔移民的女儿接受第一剂疫苗以及完成所有三剂 HPV 疫苗。次要结果将包括：9 至 12 岁女儿的拉丁裔移民母亲对 HPV/宫颈癌和 HPV 疫苗的态度和信念发生变化。拟议的研究解决了一个重要的科学知识差距 因为对于拉丁裔移民的女儿（HPV 感染和宫颈癌的高危人群）的 HPV 疫苗接种情况知之甚少。如果证明成功，这种干预措施可能会传播给美国各地拉丁裔移民的女儿，并有可能对公共卫生产生重大影响。