Understanding the Transition From Low Birth Weight to Insulin Resistance in Chil

了解儿童从低出生体重到胰岛素抵抗的转变

• 批准号: 8354720
• 负责人: Eugene Tull
• 金额: $ 19.53万
• 依托单位: UNIVERSITY OF THE VIRGIN ISLANDS
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8354720
• 关键词: Accounting; Adolescent; Adult; African American; African Caribbean; Age; Barbados; Birth; Caribbean region; Child; Childhood; Development; Diabetes Mellitus; Environment; Epidemic; Family history of; Gender; Genetic Predisposition to Disease; Health system; High Prevalence; Hormones; Hydrocortisone; Incidence; Instruction; Insulin Resistance; Island; Lead; Life; Link; Low Birth Weight Infant; Metabolic Diseases; Mothers; Non-Insulin-Dependent Diabetes Mellitus; Phase; Physiological Processes; Population; Prevalence; Principal Investigator; Public Health; Reporting; Research; Risk; Risk Factors; Services; United States Virgin Islands; Weight Gain; Woman; coping; health disparity; lifestyle factors; prevent; prevention service; programs; racism; social

PROJECT SUMMARY (See instructions): In the U.S. Virgin Islands (USVI) as on the US mainland, the prevalence of diabetes mellitus has reached epidemic levels in children. In the USA the higher prevalence of Type 2 diabetes in African American children is linked to their greater tendency to insulin resistance which cannot be accounted for by conventional risk factors. The incidence of childhood diabetes is reported to be higher in the USVI compared to other eastern Caribbean populations, and this difference does not appear to be related to differences in genetic susceptibility. Preliminary research suggest that use of certain coping styles by Afro-Caribbean women is associated with dysregulation of the hormone Cortisol which is associated with increased risk for low birth weight and subsequent development of insulin resistance in children. However the link between coping styles, low birth weight and insulin resistance in Afro-Caribbean or African American children has not been explored. Preliminary research has also shown that catch-up weight gain among children born low birth weight is associated with insulin resistance in Afro-Caribbean adolescents age 14 to 16. Little is known about how a mother's coping styles might influence lifestyle factors that contribute to catch-up weight gain in Afro-Caribbean or African American Children. The proposed study will examine the relationship of a mother's coping style to dysregulation of the hormone Cortisol, low birth weight, weight gain from birth and insulin resistance in USVI children. Moreover, the study will assess whether relationships between gender, low birth weight, catch-up weight gain, family history of diabetes and insulin resistance that were observed in Afro-Caribbean adolescents extend to children ages 2 to 4.

项目概述（见说明）：