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SEPA III: The Effectiveness Trial

SEPA III：有效性试验

基本信息

批准号：
8352598
负责人：
Nilda P Peragallo Montano
金额：
$ 21.18万
依托单位：
UNIVERSITY OF MIAMI CORAL GABLES
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-12-01 至 2017-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8352598
关键词：
AIDS prevention ARHGEF5 gene Accounting Acculturation Acquired Immunodeficiency Syndrome Address Age Alcohol consumption Behavior Cause of Death Centers for Disease Control and Prevention (U.S.)Centers of Research Excellence Characteristics Chlamydia trachomatis Communication Communities Community Practice Conflict (Psychology)County Dependency Diagnosis Economics Effectiveness Evaluation Evidence based practice Family Florida Foundations Frequencies Gender Goals HIV HIV Infections Health Health Personnel Health education High Risk Woman Hispanics Human Resources Incidence Inequality Intervention Knowledge Life Linear Models Logistic Regressions Low income Mediating Mediation Men&apos s Role Mexican Minority Neisseria gonorrhoeae Not Hispanic or Latino Nurses&apos Health Study Partner Communications Population Prevention Prevention strategy Preventive Intervention Problem Solving Public Health Puerto Rican Randomized Randomized Controlled Trials Readiness Recruitment Activity Relative (related person)Religious Belief Reporting Research Research Design Risk Risk Behaviors Risk Reduction Sampling School Nursing Self Care Services Sex Behavior Sexually Transmitted Diseases Site Syphilis Testing Time Translating Universities Waiting Lists Woman Women&apos s Health Women&apos s Role community setting condoms effectiveness trial evidence base health disparity improved intervention effect intimate partner violence minority health motherhood novel peer research study response sex sexually active skills training therapy design violence prevention

项目摘要

The proposed study's overarching goal is to reduce the ethnic disparities in HIV between Hispanic and non-Hispanic women. This goal will be accomplished by two aims: Aim 1 is to establish a novel and effective partnership to improve minority health by integrating SEPA (i.e., Salud, Educacion, Prevencion y Autocuidado; Health, Education, Prevention and Self-Care) an evidenced based, HIV preventive intervention into community setting while assessing agency and facilitator characteristics and readiness for practice improvement, implementation, fidelity, and sustainability; and Aim 2 is to evaluate the effectiveness of SEPA to increase HIV prevention behaviors and to reduce the incidence of STIs for Hispanic women when delivered in a real-world setting by community agency personnel. 300 Spanish-speaking Hispanic women between the ages of 18 and 50 who are sexually active will be recruited from one of four Miami-Dade County Public Health Department sites and randomized to either SEPA or a Wait-List Control condition. SEPA has been evaluated and found to be efficacious in two separate randomized controlled trials. In the first study (Peragallo et al., 2005), SEPA was shown to be efficacious relative to a Wait List Control condition in increasing the frequency of condom use, increasing partner communication regarding sex, and increasing HIV knowledge. In the second study (Peragallo et al., 2011), SEPA was efficacious (relative to Wait List Control) in reducing the incidence of STIs, in increasing the frequency of condom use, increasing partner communication, reducing intimate partner violence, and decreasing alcohol use. Partner communication regarding sex mediated the effects of the intervention on frequency of condom use. Hierarchical Linear Modeling (HLM) will be used to test (HI a): SEPA will be more effective relative to Wait List Control in reducing unprotected sexual behavior (defined as frequency of condom use in the past 90 days) over time. Logistic Regression will be used to test (H2a): SEPA will be more effective relative to Wait List Control in reducing STI incidence (specifically, the incidence of Neisseria gonorrhea. Chlamydia trachomatis, and Syphilis). Additionally, HLM and logistic regression, respectively, will be used to determine whether (H1b): The effect of SEPA on unprotected sexual behavior will be partially mediated by improvements in sexual communication with partner; and (H2b) The effect of SEPA on STI incidence will be partially mediated by improvements in sexual communication with partner and reductions in unprotected sexual behavior.

这项拟议的研究的首要目标是减少西班牙裔和非西班牙裔妇女在艾滋病毒方面的种族差异。这一目标将通过两个目标实现：目标1是建立一种新型和有效的伙伴关系，通过将SEPA(即Salud、Education acion、Prevencion y Autocuidado；Health、Education、Prevencion y Autocuidado；Health、Education、Prevencion y Autocuidado)纳入社区环境，同时评估机构和促进者的特点以及对实践改进、实施、忠诚度和可持续性的准备情况，将以证据为基础的艾滋病毒预防干预措施纳入社区环境；目标2是评估SEPA在增加艾滋病毒预防行为和减少由社区机构人员在真实环境中提供的西班牙裔妇女性传播感染的有效性。300名年龄在18岁至50岁之间、性行为活跃的西班牙语拉美裔女性将从迈阿密-戴德县公共卫生部门的四个地点之一招募，并随机进入SEPA或等待名单控制条件。 SEPA已经在两个单独的随机对照试验中进行了评估，并被发现是有效的。在第一项研究中(Peragallo等人，2005年)，相对于等待名单控制条件，SEPA被证明在增加避孕套的使用频率、增加与性有关的性交流以及增加艾滋病毒知识方面是有效的。在第二项研究中(Peragallo等人，2011年)，SEPA(相对于轮候名单控制)有效地降低了性传播感染的发生率，增加了避孕套的使用频率，增加了与伴侣的交流，减少了亲密伴侣的暴力行为，并减少了酒精的使用。性伴侣沟通对避孕套使用频率的影响起到了中介作用。将使用分层线性建模(HLM)来测试(HI A)：在随着时间的推移减少无保护的性行为(定义为在过去90天内使用避孕套的频率)方面，SEPA将比等待名单控制更有效。将使用Logistic回归检验(H2A)：在降低STI发病率(特别是奈瑟氏菌淋病)方面，SEPA将比等待名单控制更有效。沙眼衣原体和梅毒)。此外，HLM和Logistic回归将分别被用来确定(H1B)：SEPA对无保护性行为的影响是否将部分通过改善与伴侣的性交流来调节；(H2B)SEPA对性传播感染发病率的影响将部分通过改善与伴侣的性交流和减少无保护的性行为来调节。