MOLECULAR BIOLOGY CORE: HIV/AIDS: PUERTO RICAN, HUMAN GENETICS, ASTHMA, NEUROSCI

分子生物学核心实验室于1995年在庞塞医学院（PSM）成立。在NCRR-RCMI的持续支持下，这项核心活动的能力和用户数量都有了巨大的增长，并对PSM研究人员在人类健康和健康差异方面的生产力产生了切实的影响，在过去的RCMI周期中，引用我们服务的演讲和出版物增加了500%以上。MBCL将在这一竞争更新中进入一个新的阶段，我们将继续把重点放在我们的基本使命上，通过促进现有教师和未来新员工在工作中实施分子生物学研究，提供获取、培训和项目开发援助。作为下一阶段的一部分，我们的使命将扩大到更重视服务，并将增加新的尖端技术来调节体外和体内的基因表达，以补充我们现有的基因表达分析和遗传学研究能力。我们将通过以下四个目标来实现这些目标：目标1——扩大对设备和设施的使用；目标2 -提供技术/科学支援；目标3 -为教职员提供培训；目标四-积极推动新项目的发展和新技术的应用。MBCL的所有活动都将采用评估本核心目标的适用性和成功程度的方法进行评估。此外，已经设计并开始执行一项退款制度，以便继续使这项由皇家医学协会赞助的重要活动制度化。

The Molecular Biology Core Laboratory was established in 1995 at the Ponce School of Medicine (PSM). With the continuous support of NCRR-RCMI, this Core activity has experienced tremendous growth in capacity, number of users and has tangibly impacted upon the productivity of the research faculty in human health and health disparities at PSM, with over a 500% increase in presentations and publications citing our services in the past RCMI cycle. The MBCL will enter a new phase in this competing renewal that will continue to place major emphases on our fundamental mission to provide Access, Training, and Project Development assistance by promoting the implementation of molecular biology research in the work of both our current faculty and future recruits. As part of this next phase, our mission will expand to include greater emphasis on Service and will add new cutting edge technologies to modulate gene expression both in vitro and in vivo to complement our existing capacity to perform gene expression analyses and genetics studies. We will pursue these goals via four aims, briefly: Aim 1 - To expand access to equipment and facilities; Aim 2 - To provide technical/scientific support; Aim 3 - To provide training for faculty and staff; and, Aim 4 - To actively promote the development of new projects and use of new technologies. All activities of the MBCL will be evaluated using methods to assess suitability and success in addressing the goals of this Core. In addition, a system of charge backs has been designed and begun to be implemented in order to provide for the continued institutionalization of this essential RCMI-sponsored activity. Public Statement Molecular biology is a field with tremendous capacity to advance our scientific understanding of disease and human health. Our Core facility provides a centralized source of expertise and access to sophisticated instrumentation in order to increase the productivity of the scientists at PSM so that they may more quickly make discoveries that can be translated to clinical implementation and thus have a measureable impact on improving health in the US and worldwide.