MOLECULAR BIOLOGY CORE: HIV/AIDS: PUERTO RICAN, HUMAN GENETICS, ASTHMA, NEUROSCI

分子生物学核心：艾滋病毒/艾滋病：波多黎各人、人类遗传学、哮喘、神经科学

• 批准号: 8573385
• 负责人: Caldera Idhaliz Flores
• 金额: $ 28.27万
• 依托单位: PONCE SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至 2014-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8573385
• 关键词: AIDS/HIV problem; Address; Area; Asthma; Back; Biological Models; Cancer Center; Charge; Clinical; Collaborations; Complement; Consultations; Core Facility; DNA Sequence; Data; Detection; Development; Equipment; Faculty; Funding; Funding Mechanisms; Future; Gene Expression; Gene Expression Profiling; Genetic; Genotype; Goals; Growth; Health; Human; Human Genetics; Image; In Vitro; Institutionalization; Laboratories; Lead; Methods; Mission; Molecular; Molecular Biology; Molecular Biology Techniques; Molecular Cloning; Mutation Detection; National Center for Research Resources; Phase; Pilot Projects; Price; Principal Investigator; Productivity; Proteins; Publications; Puerto Rican; Recruitment Activity; Request for Proposals; Research; Research Infrastructure; Research Institute; Research Personnel; Sampling; Scientist; Services; Small Interfering RNA; Source; Students; System; Techniques; Technology; Training; Translating; Universities; Work; base; career; design; experience; gene function; genetic analysis; genetic linkage; health disparity; human disease; improved; in vivo; instrumentation; medical schools; member; new technology; practical application; programs; protein expression; success; tool; training project

The Molecular Biology Core Laboratory was established in 1995 at the Ponce School of Medicine (PSM). With the continuous support of NCRR-RCMI, this Core activity has experienced tremendous growth in capacity, number of users and has tangibly impacted upon the productivity of the research faculty in human health and health disparities at PSM, with over a 500% increase in presentations and publications citing our services in the past RCMI cycle. The MBCL will enter a new phase in this competing renewal that will continue to place major emphases on our fundamental mission to provide Access, Training, and Project Development assistance by promoting the implementation of molecular biology research in the work of both our current faculty and future recruits. As part of this next phase, our mission will expand to include greater emphasis on Service and will add new cutting edge technologies to modulate gene expression both in vitro and in vivo to complement our existing capacity to perform gene expression analyses and genetics studies. We will pursue these goals via four aims, briefly: Aim 1 - To expand access to equipment and facilities; Aim 2 - To provide technical/scientific support; Aim 3 - To provide training for faculty and staff; and, Aim 4 - To actively promote the development of new projects and use of new technologies. All activities of the MBCL will be evaluated using methods to assess suitability and success in addressing the goals of this Core. In addition, a system of charge backs has been designed and begun to be implemented in order to provide for the continued institutionalization of this essential RCMI-sponsored activity. Public Statement Molecular biology is a field with tremendous capacity to advance our scientific understanding of disease and human health. Our Core facility provides a centralized source of expertise and access to sophisticated instrumentation in order to increase the productivity of the scientists at PSM so that they may more quickly make discoveries that can be translated to clinical implementation and thus have a measureable impact on improving health in the US and worldwide.

分子生物学核心实验室于1995年在庞塞医学院(PSM)成立。在NCRR-RCMI的持续支持下，这项核心活动在容量和用户数量方面经历了巨大的增长，并对PSM人类健康和健康差距方面的研究人员的生产力产生了切实的影响，在过去的RCMI周期中，引用我们服务的演示和出版物增加了500%以上。MBCL将进入这一竞争性更新的新阶段，通过促进分子生物学研究在我们现有教员和未来新员工的工作中的实施，我们将继续把主要重点放在我们的基本使命上，即提供访问、培训和项目开发援助。作为下一阶段的一部分，我们的使命将扩大到更加重视服务，并将增加新的尖端技术来调节体外和体内的基因表达，以补充我们进行基因表达分析和遗传学研究的现有能力。简而言之，我们将通过四个目标来实现这些目标：目标1--扩大获得设备和设施的机会；目标2--提供技术/科学支持；目标3--为教职员工提供培训；以及目标4--积极促进新项目的开发和新技术的使用。将使用评估该核心目标的适宜性和成功程度的方法对MBCL的所有活动进行评估。此外，已经设计并开始实施退款制度，以便使这项由红十字会赞助的基本活动继续制度化。 公开声明 分子生物学是一个具有巨大潜力的领域，可以促进我们对疾病和人类健康的科学理解。我们的核心设施提供集中的专业知识来源和使用复杂仪器的途径，以提高PSM科学家的生产率，使他们可以更快地做出可转化为临床实施的发现，从而对改善美国和世界各地的健康状况产生可衡量的影响。