A Longitudinal Study of Alcohol Dependence in Late Adolescence

青春期后期酒精依赖的纵向研究

• 批准号: 8335482
• 负责人: Tim Bogg
• 金额: $ 23.94万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-20 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8335482
• 关键词: 18 year old; Accounting; Address; Adolescence; Adolescent; Affect; Alcohol abuse; Alcohol dependence; Alcohols; Anterior; Antisocial Personality Disorder; Award; Behavior; Behavioral; Buffers; Cognitive; Cognitive remediation; Complement; Development; Diagnosis; Diagnostic; Disease; Drug Addiction; Employee; Family; Feedback; Functional Magnetic Resonance Imaging; Goals; Growth; Image; Incentives; Individual; Individual Differences; Informal Social Control; Instruction; Intervention; Investigation; Investments; Knowledge; Life; Longitudinal Studies; Marijuana; Mission; Modeling; Morbidity - disease rate; Organism; Outcome; Parents; Participant; Pathway interactions; Pattern; Personality; Personality Development; Personality Traits; Pharmaceutical Preparations; Probability; Problem behavior; Protocols documentation; Research; Resources; Risk; Risk Behaviors; Risk Marker; Role; Sampling; Self-control as a personality trait; Short-Term Memory; Signal Transduction; Social Controls; Source; Spouses; Structure; Students; Training; United States National Institutes of Health; Work; aged; alcohol risk; analog; base; burden of illness; career; cingulate cortex; college; design; diaries; disability; emerging adult; experience; improved; insight; interest; meetings; mortality; neural patterning; neuroimaging; psychologic; relating to nervous system; social; theories; trait; trend; university student

The goal of this application is to extend a line of research examining markers of risk for alcohol dependence and co-morbid disinhibitory problems. Specifically, this application proposes a first aim of investigating the predictive influence of personality traits related to self-control and responsibility, cognitive capacity (in the forms of IQ and working memory), and social investment on patterns of change and continuity in alcohol dependence and co-morbid disinhibitory problems (i.e., marijuana, and other drug dependence, and conduct and antisocial personality disorders). A second aim is designed tp examine concurrent trends in related neural activation, as assessed via functional magnetic resonance imaging (fMRI) using the Balloon Analogue Risk Task. Focusing on the development of these problems in late adolescence will allow for two important questions to be addressed: 1) What developmental trajectories of alcohol and co-morbid disinhibitory problems can be predicted from assessing the development of personality traits related to self-control and responsibility, cognitive capacity, and social investment? and 2) How do individual differences in risk-related neural activation prospectively predict developmental patterns of problems and how do developmental patterns of neural activation correspond to observed patterns of development among personality traits related to responsibility and self-control, cognitive capacity, social investment, and alcohol problems? Addressing these questions will facilitate the third aim of piloting an intervention using social investment inducements and cognitive remediation, as well as help establish the Pi's long-term career goal of developing sophisticated models of self-regulation for alcohol dependence and co-morbid disinhibitory problems. The above aims will be addressed using a 24-month five-wave longitudinal study of approximately 220 college-aged participants, a monthly diary design using 100 college-aged participants, and a pilot intervention with neuroimaging using 40 college-aged participants. Previous research indicates such participants are well suited for addressing ontogenetic questions due to the developmental dynamism of the major constructs and outcomes of interest in late adolescence and early adulthood.

这项申请的目的是扩展一系列研究，检查酒精依赖的风险标志物 和共同病态的去抑制问题。具体地，本申请提出了研究本发明的第一目的。 与自我控制和责任感相关的人格特质的预测影响，认知能力（在 智商和工作记忆的形式），以及对酒精变化和连续性模式的社会投资 依赖性和共病的去抑制问题（即，大麻和其他药物依赖，以及行为 和反社会人格障碍）。第二个目的是检查相关的并发趋势， 使用球囊通过功能性磁共振成像（fMRI）评估神经激活 模拟风险任务。关注这些问题在青春期后期的发展， 需要解决的重要问题：1）酒精和共病的发展轨迹是什么 去抑制问题可以通过评估人格特征的发展来预测， 自我控制和责任感，认知能力和社会投资？（2）个人如何 风险相关神经激活的差异前瞻性地预测问题的发展模式， 神经激活的发展模式如何与观察到的发展模式相对应？ 与责任感和自我控制、认知能力、社会投资和酒精相关的人格特质 问题？解决这些问题将有助于实现第三个目标，即利用社会干预进行试点 投资激励和认知补救，以及帮助建立Pi的长期职业目标 开发复杂的酒精依赖自我调节模型和共病去抑制 问题上述目标将通过一项为期24个月的五波纵向研究来实现， 大约220名大学年龄的参与者，每月日记设计使用100名大学年龄的参与者， 以及一项使用40名大学年龄参与者的神经成像试点干预。先前的研究表明， 由于发育的动态性，这些参与者非常适合解决个体发育问题 在青春期后期和成年早期的主要结构和结果的兴趣。