A Longitudinal Study of Alcohol Dependence in Late Adolescence

青春期后期酒精依赖的纵向研究

• 批准号: 7756068
• 负责人: Tim Bogg
• 金额: $ 12.31万
• 依托单位: TRUSTEES OF INDIANA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-05 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7756068
• 关键词: 18 year old; Accounting; Address; Adolescence; Adolescent; Affect; Age; Alcohol abuse; Alcohol dependence; Alcohols; Anterior; Antisocial Personality Disorder; Award; Behavior; Behavioral; Buffers; Cognitive; Collaborations; Complement; Development; Diagnosis; Diagnostic; Disease; Doctor of Philosophy; Drug Addiction; Employee; Family; Feedback; Functional Magnetic Resonance Imaging; Goals; Growth; Image; Incentives; Individual; Individual Differences; Informal Social Control; Intervention; Investigation; Investments; Knowledge; Life; Longitudinal Studies; Marijuana; Mentors; Mission; Modeling; Morbidity - disease rate; Organism; Outcome; Parents; Participant; Pathway interactions; Pattern; Personality; Personality Development; Personality Traits; Pharmaceutical Preparations; Phase; Principal Investigator; Probability; Problem behavior; Protocols documentation; Research; Resources; Risk; Risk Behaviors; Role; Sampling; Self-control as a personality trait; Short-Term Memory; Signal Transduction; Social Controls; Source; Spouses; Structure; Students; Testing; Time; Training; United States National Institutes of Health; Work; alcohol risk; base; burden of illness; career; cingulate cortex; college; design; diaries; disability; emerging adult; experience; improved; insight; interest; longitudinal design; meetings; model development; mortality; neural patterning; neuroimaging; programs; psychologic; public health relevance; relating to nervous system; social; theories; therapy design; trait; trend; university student

DESCRIPTION (provided by applicant): The goal of this application is to extend a line of research examining major self-regulatory influences on alcohol dependence and co-morbid disinhibitory problems started in collaboration with the primary mentor, Peter Finn, Ph.D. Specifically, this application proposes a first aim of investigating the predictive influence of personality traits related to self-control and responsibility, cognitive capacity (in the form of executive working memory), and social investment on patterns of change and continuity in alcohol dependence and co-morbid disinhibitory problems (i.e., marijuana, and other drug dependence, and conduct and antisocial personality disorders). A second aim is designed to examine concurrent trends in related neural activation, as assessed via functional magnetic resonance imaging (fMRI) using a change signal task. Focusing on the development of these problems in late adolescence will allow for two important questions to be addressed: 1) What developmental trajectories of alcohol and co-morbid disinhibitory problems can be predicted from assessing the development of personality traits related to self-control and responsibility, executive working memory, and social investment? and 2) How do individual differences in neural activation prospectively predict developmental patterns of problems and how do developmental patterns of neural activation correspond to observed patterns of development among personality traits related to responsibility and self-control, executive working memory, social investment, and alcohol problems? Addressing these questions would help establish the PI's long-term career goal of developing sophisticated models of self-regulation for alcohol dependence and co-morbid disinhibitory problems and using those models to test possible interventions (i.e., the third aim in the ROO phase). In the K99 phase, the above aims will be addressed using a two-year five-wave longitudinal study of approximately 200 college-aged participants. Previous research indicates such participants are well suited for addressing ontogenetic questions due to the developmental dynamism of the major constructs and outcomes of interest in late adolescence and early adulthood. Subsequent research in the three-year ROO phase also will use a longitudinal design, as well as a monthly diary design and a pilot intervention design, all with neuroimaging components. PUBLIC HEALTH RELEVANCE: Because the plan seeks to predict one of the leading behavioral contributors to mortality (i.e., alcohol dependence) using a conceptually and methodologically integrative framework, it explicitly addresses the NIH mission of producing knowledge related to the "behavior of living systems and the application of that knowledge to extend healthy life and reduce the burdens of illness and disability."

描述（由申请人提供）：本应用程序的目标是扩展与主要导师Peter Finn博士合作开始的关于酒精依赖和共病去抑制问题的主要自我调节影响的研究线。具体而言，本应用程序提出的第一个目标是调查与自我控制和责任相关的人格特征的预测影响，认知能力（以执行工作记忆的形式），以及对酒精依赖和共病去抑制问题（即大麻和其他药物依赖，以及行为和反社会人格障碍）的变化和连续性模式的社会投资。第二个目的是通过使用变化信号任务的功能性磁共振成像（fMRI）来评估相关神经激活的并发趋势。关注这些问题在青春期后期的发展将允许解决两个重要问题：1)通过评估与自我控制和责任、执行工作记忆和社会投资相关的人格特征的发展，可以预测酒精和共病去抑制问题的发展轨迹？2)神经激活的个体差异如何前瞻性地预测问题的发展模式，神经激活的发展模式如何与观察到的与责任和自我控制、执行工作记忆、社会投资和酒精问题相关的人格特质的发展模式相对应？解决这些问题将有助于确立PI的长期职业目标，即开发酒精依赖和共病去抑制问题的复杂自我调节模型，并使用这些模型来测试可能的干预措施（即，ROO阶段的第三个目标）。在K99阶段，上述目标将通过对大约200名大学年龄参与者进行为期两年的五波纵向研究来解决。先前的研究表明，由于青春期晚期和成年早期的主要结构和结果的发展动态，这些参与者非常适合解决个体发生问题。在为期三年的ROO阶段的后续研究也将使用纵向设计，以及每月日记设计和试点干预设计，所有这些都具有神经成像组件。