The Role of Depression in the development of Alcohol Problems Among Adolescents

描述(由申请者提供)：本申请提交给NIAAA是为了响应项目公告08-167对现有酒精流行病学数据的二次分析，该项目旨在支持“更充分地利用现有数据集以增加我们对人群中与酒精相关的问题和障碍的发生率、流行率和病因以及与其相关的风险和保护因素的了解的研究”。这项研究将讨论抑郁症状是否以及如何单独并结合行为问题、发育过程和社会背景风险因素影响青春期有问题的酒精使用的发展。发展路径项目(DPP)是一项以社区为基础的纵向研究，旨在了解青春期抑郁症的发展轨迹，以及共同存在的行为问题。民进党是从城市学区招募的521名男孩和女孩的种族多样性样本，他们被招募为六年级学生(11-12岁)。对样本进行了为期六年的跟踪调查，年龄从17岁到18岁不等。研究样本最初是按精神病理风险状况分层的，有抑郁和行为问题的青少年被过度抽样。自成立以来，DPP一直在收集有关酒精和其他药物使用的广泛数据，并在12年级(17-18岁)评估中确定12个月的酒精滥用和依赖诊断。在我们的第一个目标中，我们将比较考察抑郁和行为问题的经验模型，将其作为单独的主效应，作为交互作用，以及仅通过共同的前置因素与饮酒有关的模型，探索总体增长、严重性、持久性和时间敏感性效应。目标2将通过纳入可能中介、调节和直接影响酒精问题发展风险的发展过程和社会背景因素，建立一个更全面的酒精问题模型。第三个目标集中在抑郁和行为问题的作用，因为它们与早期启动和从使用到问题使用的过渡有关。结果将对进一步完善和加强预防和干预措施产生直接影响，以加强其在减少青少年酗酒和减少问题方面的有效性。 与公共健康相关：美国未成年青年饮酒构成了一个公共健康问题，具有严重的社会、经济和个人成本。拟议的研究结果将为扩大青少年酒精相关问题的有效预防和治疗战略提供信息。这项研究响应了NIAAA的未成年人饮酒研究倡议，以及卫生局局长关于预防和减少未成年人饮酒的行动呼吁。

DESCRIPTION (provided by applicant): This application is submitted to NIAAA in response to Program Announcement 08-167 Secondary Analysis of Existing Alcohol Epidemiological Data which was created to support "studies that more fully utilize currently available data sets to increase our understanding of the incidence, prevalence and etiology of alcohol related problems and disorders in the population, as well as the risk and protective factors associated with them." This study will address the question of whether and how depressive symptoms, in isolation and in combination with conduct problems, developmental processes, and social contextual risk factors, influence the development of problematic alcohol use in adolescence. The Developmental Pathways Project (DPP) is a community-based longitudinal study that aims to understand developmental trajectories for depression, and comorbid conduct problems, across the adolescent period. DPP constitutes a racially diverse sample of 521 boys and girls who were recruited as sixth graders (age 11-12) from an urban school district. The sample has been followed over the course of six years, to age 17-18. The study sample was originally stratified on psychopathology risk status, and adolescents with depressive and conduct problems were oversampled. DPP has been collecting extensive data on alcohol and other drug use since its inception and is also determining 12-month diagnoses of Alcohol Abuse and Dependence at the 12th grade (17-18 year-old) assessment. In our first aim, we will compare empirical models examining depression and conduct problems as separate main effects, as interactive, and as related to alcohol use only by virtue of common antecedents, exploring overall growth, severity, persistence, and time-sensitive effects. Aim 2 will build up a more comprehensive model of alcohol problems by incorporating developmental processes and social-contextual factors that may mediate, moderate, and have direct effects on risk for the development of alcohol problems. The third aim focuses on the role of depression and conduct problems as they relate to early initiation and transition from use to problem use. Results will have direct implications for further refining and enhancing prevention and intervention approaches to bolster their effectiveness in reducing alcohol involvement and problems among youth. PUBLIC HEALTH RELEVANCE: The consumption of alcohol by underage youth in America constitutes a public health problem with serious social, economic, and personal costs. The results of the proposed study will inform the expansion of effective prevention and treatment strategies for alcohol-related problems in adolescence. This research is responsive to NIAAA's Underage Drinking Research Initiative, as well as the Surgeon General's Call to Action to Prevent and Reduce Underage Drinking.