The Role of Depression in the development of Alcohol Problems Among Adolescents

抑郁症在青少年酒精问题发展中的作用

• 批准号: 8046496
• 负责人: CAROLYN A MC CARTY
• 金额: $ 27.39万
• 依托单位: SEATTLE CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8046496
• 关键词: 18 year old; Accounting; Address; Adolescence; Adolescent; Adolescent Development; Age; Alcohol abuse; Alcohol consumption; Alcohol dependence; Alcohols; Americas; Collection; Communities; Consensus; Data; Data Set; Development; Developmental Process; Diagnosis; Disease; Drug usage; Economics; Effectiveness; Epidemiology; Etiology; Family; Funding; Growth; Incidence; Longitudinal Studies; Mediating; Mental Depression; Modeling; NIH Program Announcements; National Institute of Drug Abuse; National Institute of Mental Health; National Institute on Alcohol Abuse and Alcoholism; Outcome; Pathway interactions; Play; Population; Prevalence; Prevention strategy; Preventive Intervention; Process; Psychopathology; Public Health; Recruitment Activity; Research; Research Project Grants; Risk; Risk Factors; Role; Sampling; Sampling Studies; Schools; Severities; Sex Characteristics; Stress; Surgeon; Temperament; Testing; Time; Youth; alcohol and other drug; alcohol involvement; alcohol related problem; alcohol risk; alcohol use initiation; base; boys; contextual factors; cost; depressive symptoms; early adolescence; girls; peer; prevent; pubertal timing; public health relevance; response; social; treatment strategy; underage drinking; underage drinking reduction

DESCRIPTION (provided by applicant): This application is submitted to NIAAA in response to Program Announcement 08-167 Secondary Analysis of Existing Alcohol Epidemiological Data which was created to support "studies that more fully utilize currently available data sets to increase our understanding of the incidence, prevalence and etiology of alcohol related problems and disorders in the population, as well as the risk and protective factors associated with them." This study will address the question of whether and how depressive symptoms, in isolation and in combination with conduct problems, developmental processes, and social contextual risk factors, influence the development of problematic alcohol use in adolescence. The Developmental Pathways Project (DPP) is a community-based longitudinal study that aims to understand developmental trajectories for depression, and comorbid conduct problems, across the adolescent period. DPP constitutes a racially diverse sample of 521 boys and girls who were recruited as sixth graders (age 11-12) from an urban school district. The sample has been followed over the course of six years, to age 17-18. The study sample was originally stratified on psychopathology risk status, and adolescents with depressive and conduct problems were oversampled. DPP has been collecting extensive data on alcohol and other drug use since its inception and is also determining 12-month diagnoses of Alcohol Abuse and Dependence at the 12th grade (17-18 year-old) assessment. In our first aim, we will compare empirical models examining depression and conduct problems as separate main effects, as interactive, and as related to alcohol use only by virtue of common antecedents, exploring overall growth, severity, persistence, and time-sensitive effects. Aim 2 will build up a more comprehensive model of alcohol problems by incorporating developmental processes and social-contextual factors that may mediate, moderate, and have direct effects on risk for the development of alcohol problems. The third aim focuses on the role of depression and conduct problems as they relate to early initiation and transition from use to problem use. Results will have direct implications for further refining and enhancing prevention and intervention approaches to bolster their effectiveness in reducing alcohol involvement and problems among youth. PUBLIC HEALTH RELEVANCE: The consumption of alcohol by underage youth in America constitutes a public health problem with serious social, economic, and personal costs. The results of the proposed study will inform the expansion of effective prevention and treatment strategies for alcohol-related problems in adolescence. This research is responsive to NIAAA's Underage Drinking Research Initiative, as well as the Surgeon General's Call to Action to Prevent and Reduce Underage Drinking.

描述（申请人提供）：本申请提交给NIAAA是为了响应计划公告08-167现有酒精流行病学数据的二次分析，该公告旨在支持“更充分地利用现有数据集的研究，以增加我们对人群中酒精相关问题和疾病的发生率、患病率和病因的理解，以及与之相关的风险和保护因素。“这项研究将探讨抑郁症状是否以及如何与行为问题，发展过程和社会背景风险因素相结合，影响青少年有问题的酒精使用的发展。发展途径项目（DPP）是一项以社区为基础的纵向研究，旨在了解整个青少年时期抑郁症和共病行为问题的发展轨迹。民进党构成了一个种族多样化的样本521名男孩和女孩谁被招募为六年级（11-12岁）从城市学区。样本被跟踪了六年，直到17-18岁。研究样本最初是根据精神病理学风险状态分层的，有抑郁和品行问题的青少年被过度抽样。DPP自成立以来一直在收集有关酒精和其他药物使用的广泛数据，并在12年级（17-18岁）评估中确定12个月的酒精滥用和依赖诊断。在我们的第一个目标，我们将比较实证模型检查抑郁症和行为问题作为单独的主要影响，作为互动，并与酒精使用仅凭借共同的前因，探索整体增长，严重性，持久性和时间敏感的影响。目标2将建立一个更全面的酒精问题模型，将发展过程和社会背景因素，可能调解，适度，并对酒精问题的发展风险有直接影响。第三个目标侧重于抑郁症和行为问题的作用，因为它们涉及到早期启动和从使用到问题使用的过渡。研究结果将直接影响到进一步完善和加强预防和干预方法，以提高其在减少青年酗酒和酗酒问题方面的效力。 公共卫生相关性：在美国，未成年人饮酒构成了一个公共卫生问题，造成了严重的社会、经济和个人代价。拟议研究的结果将为扩大有效预防和治疗青少年酒精相关问题的战略提供信息。这项研究是响应NIAAA的未成年人饮酒研究倡议，以及卫生部长的行动呼吁，以防止和减少未成年人饮酒。