Sensorimotor Training to Affect Balance, Engagement and Learning in Children with

感觉运动训练可影响儿童的平衡、参与和学习

• 批准号: 8320854
• 负责人: TRACY L JIRIKOWIC
• 金额: $ 22.59万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8320854
• 关键词: Address; Affect; Aftercare; Age; Animal Model; Area; Attention; Balance training; Behavior; Behavioral; Biometry; Cerebral Palsy; Child; Childhood; Clinical; Clinical assessments; Collaborations; Complex; Computers; Conflict (Psychology); Control Groups; Controlled Environment; Data; Development; Developmental Disabilities; Diagnosis; Dose; Educational Intervention; Effectiveness; Effectiveness of Interventions; Emerging Technologies; Engineering; Environment; Equilibrium; Evaluation; Fetal Alcohol Spectrum Disorder; Foundations; Funding; Goals; Home environment; Intervention; Laboratories; Learning; Maintenance; Matched Group; Measures; Motor; Movement; Musculoskeletal Equilibrium; Nature; Neurodevelopmental Disability; Neurodevelopmental Disorder; Neurodevelopmental Impairment; Neuronal Plasticity; Occupational Therapy; Outcome; Outcome Measure; Performance; Phase; Physical therapy; Pilot Projects; Play; Population; Process; Protocols documentation; Rehabilitation therapy; Relative (related person); Reporting; Research; Research Proposals; Risk; Safety; Sample Size; Sampling; Secondary to; Sensorimotor functions; Sensory; Shapes; Simulate; Sports; System; Technology; Testing; Time; Training; Weight; abstracting; alcohol exposure; autism spectrum disorder; base; behavioral health; computer science; daily functioning; developmental disease; equilibration disorder; falls; functional outcomes; high risk; improved; meetings; motor learning; neurobehavioral; neuromuscular; novel; physical conditioning; postnatal; prenatal exposure; remediation; response; sensory integration; sensory system; skills; social; somatosensory; stem; treatment effect; trend; virtual reality; visual-vestibular

Project Summary / Abstract RFA-MH-09-161: Novel Interventions for Neurodevelopmental Disorders R21/R33 Prenatal exposure to alcohol can increase the risk for lifelong neurobehavioral problems, as well as developmental disabilities that fall under the umbrella term of fetal alcohol spectrum disorders (FASD). Poor sensorimotor function, specifically balance deficits, is one area of neurodevelopmental impairment described among children with FASD. Efficient balance and postural control are important foundations for engagement in higher level functional skills such as maintaining attention, navigating an environment, controlling complex movements, and participating in childhood activities that promote physical and behavioral health and development. Balance is a complex process involving the integration sensory information and the coordination of neuromuscular responses. Despite evidence that balance deficits are problematic among children with FASD and preliminary reports that poor sensorimotor integration is suspect, the nature of these balance and postural control deficits are not fully understood. Nor have interventions to improve daily function and behavior through the remediation of underlying sensorimotor deficits been considered and tested among this population, Yet, evidence from alcohol exposed animal models indicates the capacity for neural plasticity, motor learning, and improved motor performance following complex rehabilitative training. Therefore, the overarching goal of this combined R21/R33 proposal is to determine the preliminary effectiveness of a sensorimotor intervention to improve balance and related functional and behavioral outcomes among children with FASD. Our proposed intervention will employ the use of virtual reality computer technology to train the ability to weight and reweight sensory information during balance perturbations invoked by simulated conditions of sensory conflict. As a first step, this research (R21) proposes to more fully describe balance impairments and subsequent functional impact of sensorimotor problems in children with FASD. This will be done by comparing the performance of children with FASD ages 7.0-14.9 years to a matched group of children with typical development on a battery of clinical tests and a novel assessment system that specifically examines how visual, vestibular and somatosensory information is used during balance. This data will shape the development of our proposed sensorimotor intervention technology and preliminary intervention protocol, which will be tested with a small group of children with FASD to gauge initial feasibility and responsiveness. Data from the R21 will lay the groundwork for the next phase of research (R33) that aims to refine the sensorimotor training for balance intervention technology and establish and test the effectiveness of the intervention delivered via a short-term intensive laboratory protocol or a longer term home-based protocol. Collectively, these studies lay the essential groundwork for a larger multisite efficacy study to determine the effectiveness of the intervention with a larger sample of children with FASD and other groups of children with neurodevelopmental disabilities.

项目总结/摘要 RFA-MH-09-161：神经发育障碍R21/R33的新型干预措施 产前接触酒精会增加终身神经行为问题的风险， 胎儿酒精谱系障碍（FASD）的总称下的发育障碍。贫困 感觉运动功能，特别是平衡缺陷，是神经发育障碍的一个领域， FASD患儿中。有效的平衡和姿势控制是参与的重要基础 更高层次的功能技能，如保持注意力，导航环境，控制复杂的 运动，并参与促进身体和行为健康的儿童活动， 发展平衡是一个复杂的过程，涉及到感觉信息的整合和协调 神经肌肉的反应。尽管有证据表明，平衡赤字是有问题的儿童， FASD和初步报告认为，感觉运动整合不良是可疑的，这些平衡的性质， 姿势控制缺陷还没有被完全理解。也没有干预措施来改善日常功能和行为 通过对潜在的感觉运动缺陷进行补救， 然而，来自酒精暴露动物模型的证据表明，神经可塑性，运动学习， 并在复杂的康复训练后改善运动表现。因此， 这一R21/R33组合提案旨在确定感觉运动干预的初步有效性， 改善FASD儿童平衡及相关功能和行为结果。我们提出的 干预将采用虚拟现实计算机技术来训练称重和再称重的能力 在模拟感官冲突条件引起的平衡扰动期间的感官信息。作为第一 第一步，本研究（R21）建议更全面地描述平衡障碍和随后的功能 FASD儿童感觉运动问题的影响这将通过比较 年龄为7.0-14.9岁的FASD儿童与具有典型发育的儿童相匹配 临床测试和一种新的评估系统，专门检查如何视觉，前庭和 在平衡期间使用体感信息。这些数据将塑造我们提出的发展 感觉运动干预技术和初步干预协议，这将是一个小的测试 一组患有FASD的儿童，以评估初始可行性和反应性。来自R21的数据将奠定 为下一阶段的研究（R33）奠定基础，该研究旨在完善平衡的感觉运动训练 干预技术，并建立和测试通过短期干预提供的有效性， 强化实验室方案或更长期的基于家庭的方案。总的来说，这些研究奠定了基本的 为更大规模的多中心疗效研究奠定基础，以确定干预措施的有效性， FASD儿童和其他神经发育障碍儿童的样本。