FASEB SRC on SMOOTH MUSCLE

FASEB SRC 关于平滑肌

• 批准号: 8315144
• 负责人: LIGIA G. TORO DE STEFANI
• 金额: $ 1万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-06-01 至 2013-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8315144
• 关键词: Address; Area; Asthma; Award; Biology; Bladder; Blood Vessels; CCL7 gene; Cell Communication; Cells; Chairperson; Clinical; Collaborations; Contracts; Coronary Artery Vasospasm; Cytoskeleton; Disease; Environment; Erectile dysfunction; Ethnic Origin; Etiology; Evolution; Failure; Fostering; Future; Gastrointestinal Diseases; Generations; Genetic Transcription; Goals; Growth; Health; Health Status; Hormones; Human; Hypertension; Hypertrophy; Image; Incontinence; Intention; International; Intestines; Ion Channel; Knowledge; Lead; Learning; Lung; Methodology; MicroRNAs; Minority; Modality; Muscle Tonus; Myocardial Infarction; Oral; Organ; Physiological; Prize; Proteomics; Pulmonary Hypertension; Quality of life; Recreation; Regenerative Medicine; Regulation; Relaxation; Reproductive system; Research; Research Personnel; Respiratory System; Rewards; Schedule; Science; Scientist; Secure; Signal Transduction; Smooth Muscle; Solutions; Stroke; Techniques; Technology; Time; Tissue Engineering; Tissues; Translations; Travel; Urinary Incontinence; Urinary system; Woman; abstracting; body system; cell injury; gastrointestinal system; innovation; instrument; interest; meetings; notch protein; novel; planetary Atmosphere; posters; pre-doctoral; programs; repaired; reproductive; respiratory; response; socioeconomics; stem cell biology; symposium; tissue repair; tool

DESCRIPTION (provided by applicant): Smooth muscle provides multiple hollow organs (e.g. vasculature, respiratory and reproductive tracts, intestine, and bladder) with their ability to contract or relax according to physiological needs. Thus, smooth muscle research is critical to understand the health status of several body systems including vascular, respiratory, urinary, gastrointestinal, and reproductive systems; as well as the etiology of numerous diseases, including stroke, coronary vasospasm, asthma, erectile dysfunction, incontinence, pulmonary failure. The 2012 FASEB Smooth Muscle Conference (Snowmass, CO June 24-29) will bring together prominent and young investigators from around the globe to discuss recent advances in this vital field; its significance is underscored by top-notch speakers with over 120,000 citations total, and by ~50% of the talks dealing with health related issues including hypertension, tissue repair, hypertrophy, remodeling and chemoproteomics. The conference will address innovative concepts and techniques (e.g. stem cell biology and regenerative medicine, microRNA, proteomics, and advanced imaging) promoting excellence and providing young investigators with tools to become future leaders. A "New and Notable" session will add momentum to the conference. The 4-day format is optimum with 1 keynote speaker, 8 morning and evening sessions, and afternoons dedicated for posters, "Meet the Expert" roundtables, informal discussions, and group recreation. The agenda includes sessions assembled with strong science and with many addressing translational efforts to maintain human health and quality of life. Sessions 1-2 deal with cell-to cell communication and injury-induced cell responses important to understand tissue biology, remodeling and repair. Sessions 3-4 will deal with contraction-relaxation networks including ion channels in health and disease. These topics are critical to keep muscle tone healthy, and unravel changes that occur for example in pulmonary hypertension. Sessions 5-6 cover the areas of smooth muscle functional regulation by addressing how hormones and the cytoskeleton act to control smooth muscle transcription, tone and proliferation. Session 7 is dedicated to entice researchers to shift to global approaches like proteomics to rapidly advance the field in the discovery of new health defining mechanisms or disease related markers; while Session 8 will address the New and Notable. Short oral presentations have been reserved for young investigators selected from the abstracts with the two best receiving the "Sizzling New Investigator Prizes". The environment is excellent for interactions and networking in a relaxed atmosphere. Informal discussions in "Meet the Expert" roundtables will increase the opportunities of young investigators to make liaisons with established investigators. Appropriate representation of minorities is being sought among chairs (>30% women), speakers (~30% women, 1 minority; which are expected to increase) and attendants (ads; FASEB offers MARC travel awards for minorities). In summary, the 2012 Smooth Muscle conference strives to foster diversity at all levels, innovation, and translation of basic knowledge into clinical solutions.

描述（由申请人提供）：平滑肌提供多个中空器官（例如，脉管系统、呼吸道和生殖道、肠和膀胱），具有根据生理需要收缩或舒张的能力。因此，平滑肌研究对于了解几个身体系统的健康状况至关重要，包括血管，呼吸，泌尿，胃肠道和生殖系统;以及许多疾病的病因，包括中风，冠状动脉血管痉挛，哮喘，勃起功能障碍，失禁，肺衰竭。2012年FASEB平滑肌会议（斯诺马斯，CO 6月24日至29日）将汇集来自地球仪各地的杰出和年轻的研究人员，讨论这一重要领域的最新进展;它的重要性得到了顶级演讲者的强调，引用总数超过120，000次，约50%的演讲涉及健康相关问题，包括高血压，组织修复，肥大，重塑和化学蛋白质组学。会议将讨论创新的概念和技术（如干细胞生物学和再生医学，microRNA，蛋白质组学和先进成像），促进卓越，并为年轻的研究人员提供工具，成为未来的领导者。一个"新的和值得注意的"会议将增加会议的势头。为期4天的形式是最佳的，有1个主旨发言人，8个上午和晚上的会议，下午专门用于海报，"会见专家"圆桌会议，非正式讨论和小组娱乐。该议程包括与强大的科学和许多解决转化努力，以保持人类健康和生活质量的会议。会议1 - 2处理细胞间通讯和损伤诱导的细胞反应，这对理解组织生物学、重塑和修复很重要。会议3 - 4将处理收缩-放松网络，包括健康和疾病中的离子通道。这些主题对于保持肌肉张力健康至关重要，并揭示肺动脉高压等发生的变化。第5 - 6节涵盖了平滑肌功能调节的领域，通过解决激素和细胞骨架如何控制平滑肌转录，张力和增殖。第7次会议致力于吸引研究人员转向蛋白质组学等全球方法，以快速推进新的健康定义机制或疾病相关标志物的发现领域;而第8次会议将讨论新的和值得注意的。简短的口头报告已预留给年轻的研究人员选择从摘要与两个最好的接收“新的研究者奖”。环境是极好的互动和网络在一个轻松的气氛。"会见专家"圆桌会议的非正式讨论将增加年轻调查员与资深调查员联络的机会。在主席（> 30%的妇女）、发言人（约30%的妇女，1个少数民族;预计将增加）和服务员（广告; FASEB为少数民族提供MARC旅行奖）中，正在寻求少数民族的适当代表性。总之，2012年平滑肌会议致力于促进各级多样性，创新，并将基础知识转化为临床解决方案。