FASEB SRC on SMOOTH MUSCLE

描述（由申请人提供）：平滑肌提供多个中空器官（如脉管系统、呼吸和生殖道、肠道和膀胱），它们具有根据生理需要收缩或放松的能力。因此，平滑肌研究对于了解包括血管、呼吸、泌尿、胃肠道和生殖系统在内的几个身体系统的健康状况至关重要；以及许多疾病的病因，包括中风，冠状动脉痉挛，哮喘，勃起功能障碍，失禁，肺衰竭。2012年FASEB平滑肌会议（6月24日至29日，科罗拉多州斯诺mass）将汇集来自全球的杰出和年轻的研究人员，讨论这一重要领域的最新进展；其重要性由总引用超过120,000次的顶级演讲者强调，并且约50%的演讲涉及健康相关问题，包括高血压，组织修复，肥厚，重塑和化学蛋白质组学。会议将讨论创新的概念和技术（如干细胞生物学和再生医学、microRNA、蛋白质组学和先进成像），促进卓越，并为年轻的研究人员提供成为未来领导者的工具。“新的和值得注意的”会议将为会议增添动力。4天的形式是最佳的，1个主题演讲者，8个上午和晚上的会议，下午专门用于海报，“会见专家”圆桌会议，非正式讨论和小组娱乐。会议议程包括有充分科学依据的会议，其中许多会议涉及维护人类健康和生活质量的转化努力。第1-2节涉及细胞间通讯和损伤诱导的细胞反应，这对理解组织生物学、重塑和修复很重要。第3-4节将讨论健康和疾病中的收缩-松弛网络，包括离子通道。这些主题对于保持肌肉张力健康和揭示诸如肺动脉高压等发生的变化至关重要。第5-6次会议通过解决激素和细胞骨架如何控制平滑肌转录、张力和增殖来涵盖平滑肌功能调节领域。会议7致力于吸引研究人员转向蛋白质组学等全球方法，以迅速推进该领域发现新的健康定义机制或疾病相关标志物；而第八部分将讨论新的和值得注意的。为从摘要中选出的年轻研究者保留了简短的口头报告，其中最好的两名将获得“炙手可热的新研究者奖”。环境非常适合在轻松的氛围中进行互动和交流。“会见专家”圆桌会议中的非正式讨论将增加年轻调查人员与资深调查人员建立联系的机会。在主席（约30%女性）、演讲者（约30%女性，1个少数族裔；预计会增加）和服务员（广告；FASEB为少数族裔提供MARC旅行奖励）中寻求适当的少数族裔代表。总而言之，2012年平滑肌会议致力于促进各个层面的多样性、创新和将基础知识转化为临床解决方案。

DESCRIPTION (provided by applicant): Smooth muscle provides multiple hollow organs (e.g. vasculature, respiratory and reproductive tracts, intestine, and bladder) with their ability to contract or relax according to physiological needs. Thus, smooth muscle research is critical to understand the health status of several body systems including vascular, respiratory, urinary, gastrointestinal, and reproductive systems; as well as the etiology of numerous diseases, including stroke, coronary vasospasm, asthma, erectile dysfunction, incontinence, pulmonary failure. The 2012 FASEB Smooth Muscle Conference (Snowmass, CO June 24-29) will bring together prominent and young investigators from around the globe to discuss recent advances in this vital field; its significance is underscored by top-notch speakers with over 120,000 citations total, and by ~50% of the talks dealing with health related issues including hypertension, tissue repair, hypertrophy, remodeling and chemoproteomics. The conference will address innovative concepts and techniques (e.g. stem cell biology and regenerative medicine, microRNA, proteomics, and advanced imaging) promoting excellence and providing young investigators with tools to become future leaders. A "New and Notable" session will add momentum to the conference. The 4-day format is optimum with 1 keynote speaker, 8 morning and evening sessions, and afternoons dedicated for posters, "Meet the Expert" roundtables, informal discussions, and group recreation. The agenda includes sessions assembled with strong science and with many addressing translational efforts to maintain human health and quality of life. Sessions 1-2 deal with cell-to cell communication and injury-induced cell responses important to understand tissue biology, remodeling and repair. Sessions 3-4 will deal with contraction-relaxation networks including ion channels in health and disease. These topics are critical to keep muscle tone healthy, and unravel changes that occur for example in pulmonary hypertension. Sessions 5-6 cover the areas of smooth muscle functional regulation by addressing how hormones and the cytoskeleton act to control smooth muscle transcription, tone and proliferation. Session 7 is dedicated to entice researchers to shift to global approaches like proteomics to rapidly advance the field in the discovery of new health defining mechanisms or disease related markers; while Session 8 will address the New and Notable. Short oral presentations have been reserved for young investigators selected from the abstracts with the two best receiving the "Sizzling New Investigator Prizes". The environment is excellent for interactions and networking in a relaxed atmosphere. Informal discussions in "Meet the Expert" roundtables will increase the opportunities of young investigators to make liaisons with established investigators. Appropriate representation of minorities is being sought among chairs (>30% women), speakers (~30% women, 1 minority; which are expected to increase) and attendants (ads; FASEB offers MARC travel awards for minorities). In summary, the 2012 Smooth Muscle conference strives to foster diversity at all levels, innovation, and translation of basic knowledge into clinical solutions.