Novel Accelerated Contrast-Enhanced High Resolution Coronary MRI

新型加速对比增强高分辨率冠状动脉 MRI

• 批准号: 8224036
• 负责人: Mehmet Akcakaya
• 金额: $ 10.2万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-06-01 至 2014-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8224036
• 关键词: Acceleration; Acute; Algorithms; Angiography; Calcium; Cardiac; Catheters; Cause of Death; Chronic; Clinical; Contrast Media; Coronary; Coronary Arteriosclerosis; Data; Defect; Detection; Diagnosis; Diagnostic; Ensure; Evaluation; Gadolinium; Gold; Heart; Image; Imaging Techniques; Inferior; Ionizing radiation; Learning; Magnetic Resonance Imaging; Methodology; Methods; Morphologic artifacts; Motion; Myocardial; Myocardial Infarction; Myocardial perfusion; Patients; Perfusion; Phase; Prevention; Protocols documentation; Recovery; Resolution; Risk; Sampling; Scanning; Sensitivity and Specificity; Stenosis; Structure; Techniques; Testing; Time; United States; Variant; Work; base; data acquisition; data space; diagnosis standard; follow-up; gadolinium oxide; image reconstruction; improved; method development; novel; reconstruction; spatiotemporal; two-dimensional

DESCRIPTION (provided by applicant): Coronary artery disease (CAD) is the leading cause of death in the United States, even though significant efforts have been made in prevention and diagnosis. The clinical gold standard for diagnosis of CAD is catheter-based invasive x-ray angiography, performed more than a million times per year. Of these examinations, up to 35% have been found to have no significant stenosis, yet these patients had to go through the potential risks and complications of an invasive test that further exposes the patient to ionizing radiation and iodinated contrast. Thus, non-invasive diagnostic alternatives are highly desirable. Cardiac MRI (CMR) provides a method for comprehensive non-invasive cardiac exam, including contractile functional assessment (cine CMR) to detect wall-motion abnormality, myocardial CMR perfusion for diagnosing perfusion defects, viability assessment using late gadolinium enhancement (LGE) for evaluation of acute and chronic myocardial infarction, and coronary MRI for the identification of stenosis. CMR is advantageous in several respects, since it does not require ionizing radiation or iodinated contrast, thereby facilitating repeated or follow-up scanning. However, long data acquisition time remains as one of its main limitations. Several approaches have been studied to facilitate rapid CMR acquisition. Nonetheless, the acquisition time for high-resolution CMR remains long, and spatial and temporal resolution is traded off for acquisition time in cine and perfusion imaging. Therefore, developments of methods to reduce data acquisition time beyond what is available now are appealing. We will develop novel reconstruction methodologies for high-resolution CMR that learn the anatomical structures in the images being reconstructed. We will validate these techniques in a range of contrast-enhanced CMR imaging protocols, providing better volumetric coverage of the heart, efficient use of the contrast agents, and higher spatial and temporal resolution.

描述（由申请人提供）：冠状动脉疾病（CAD）是美国的主要死亡原因，尽管在预防和诊断方面已经做出了重大努力。诊断CAD的临床金标准是基于导管的侵入性x线血管造影，每年进行超过一百万次。在这些检查中，高达35%的患者没有发现明显的狭窄，但这些患者必须经历侵入性检查的潜在风险和并发症，进一步将患者暴露于电离辐射和碘化造影剂中。因此，非侵入性诊断替代方案是非常可取的。