2012 Cardiac Regulatory Mechanisms Gordon Research Conference and Gordon Research

申请者描述(由申请者提供)：本申请旨在为将于2012年6月9日至15日在密歇根州科尔比索耶学院(Colby-Sawyer，NH)举行的心脏调节机制戈登研究会议(GRC)和戈登研究研讨会(GRS)提供部分资金。25年多来，这个会议一直以聚集新的研究人员和老牌领导人而自豪，他们展示了他们最新的未发表的发现，并参与了有意义的科学和社会互动。GRC的特殊非正式性质在促进跨越学科和地理的讨论方面是独一无二的，并使新的个人和科学联系得以发展。因此，每年都有非常多的科学家回到这个会议上。参与者是从最有前途和最多产的科学家中挑选出来的，他们的职业生涯各个阶段和不同的学科。他们的关系是一种 共同感兴趣的话题是对正常和疾病心脏的调节，重点是钙调节机制。我们有很好的基础科学，涉及正常心脏电和机械特性的调节，心肌细胞信号传递，以及这些过程中导致心脏功能障碍的异常。越来越多的转基因动物的使用和明确的心血管表型的发展使心血管系统变得易于管理，从而引起了细胞信号领域的广泛和广泛的兴趣。今年的会议特别关注信号通路，包括几个新的研究热点领域，包括线粒体钙调节、氧化还原调节、新的模型系统、亚细胞室及其实时成像。其他会议的重点是心律失常，心肌细胞中的钙信号，以及新的信号通路。讨论领导者肩负着推动生动讨论和批判性提问的历史重任，而且历来都是成功的。事实上，这次会议的一个关键目标是营造一种包容、紧张、活跃和互动的气氛，通过加深对悬而未决的问题的理解，突出争议并启发与会者。这是心血管科学中令人兴奋的时刻，因为转基因和基因敲除小鼠模型、遗传信息和新技术的使用，使我们能够探索正常心脏功能的细胞和分子基础。我们正开始将这些新发现转化为对疾病机制、诊断、预防和治疗的更好理解。我们预计，拟议的演讲将既令人兴奋又及时，并通过从海报稿件和最近的出版物中招募发言者，将最新的科学和年轻的研究人员包括在口头会议中。这是一次经常参加的人期待的会议，新与会者和年轻科学家认为这是一次宝贵的学习和职业经历。

DESCRIPTION (provided by applicant): This application seeks partial funding for the Gordon Research Conference (GRC) and the Gordon Research Seminar (GRS) on Cardiac Regulatory Mechanisms to be held at Colby Sawyer College (Colby-Sawyer, NH) on June 9-15, 2012. For more than 25 years this conference has prided itself on bringing together new investigators and established leaders to present their latest unpublished findings and engage in meaningful scientific and social interactions. The special informal nature of the GRC is unique in fostering discussions that span disciplines and geography and enables new personal and scientific connections to develop. Accordingly, an extraordinarily high number of scientists return to this conference year after year. Participants are chosen from amongst the most promising and productive scientists, at all stages in their careers and from diverse disciplines. Their bond is a common interest in the topic of regulation of the normal and diseased heart with a focus on Ca2+ regulatory mechanisms. We have a good mix of fundamental science related to regulation of normal cardiac electrical and mechanical properties, cardiac myocyte cell signaling, and abnormalities in these processes that contribute to cardiac dysfunction. The increased use of genetically modified animals and the development of defined cardiovascular phenotypes has made the cardiovascular system tractable and thus of broad and expanding interest to the cell signaling field. This year's conference has a particular focus on signaling pathways and includes several new areas of intense research interest including mitochondrial Ca2+ regulation, redox regulation, new model systems, subcellular compartments and their real time imaging. Other sessions focus on arrhythmias, Ca2+ signaling in myocytes, and novel signaling pathways. Discussion leaders are charged with and are historically successful at promoting lively discussions and critical questioning. Indeed a key objective of this conference is to foster an inclusive, intense, lively and interactive atmosphere that highlights controversies and enlightens participants by providing a deeper understanding of unresolved issues. This is an exciting time in cardiovascular science because of the use of transgenic and knockout mouse models, genetic information and new technologies that allow us to explore the cellular and molecular basis of normal cardiac function. We are beginning to translate these new findings into a better understanding of disease mechanisms, diagnosis, prevention and treatment. We expect that the proposed presentations will be both exciting and timely, and to include late breaking science and young investigators in the oral session by recruiting speakers from poster contributions and recent publications. This is a conference that those who have regularly attended look forward to, and that new attendees and young scientists recognize as an invaluable learning and career experience.