2012 Cardiac Regulatory Mechanisms Gordon Research Conference and Gordon Research

描述（由申请人提供）：本申请为戈登研究会议（GRC）和戈登心脏调节机制研究研讨会（GRS）寻求部分资金，该研讨会将于2012年6月9日至15日在科尔比索耶学院（科尔比索耶，新罕布什尔州）举行。25年来，该会议一直以汇集新研究者和知名领导者来展示他们最新的未发表的发现并参与有意义的科学和社会互动而自豪。GRC特殊的非正式性质在促进跨学科和地理的讨论方面是独一无二的，并使新的个人和科学联系得以发展。因此，每年都有非常多的科学家回到这个会议。参与者是从处于职业生涯各个阶段、来自不同学科的最有前途和最有成效的科学家中挑选出来的。它们的键是a

DESCRIPTION (provided by applicant): This application seeks partial funding for the Gordon Research Conference (GRC) and the Gordon Research Seminar (GRS) on Cardiac Regulatory Mechanisms to be held at Colby Sawyer College (Colby-Sawyer, NH) on June 9-15, 2012. For more than 25 years this conference has prided itself on bringing together new investigators and established leaders to present their latest unpublished findings and engage in meaningful scientific and social interactions. The special informal nature of the GRC is unique in fostering discussions that span disciplines and geography and enables new personal and scientific connections to develop. Accordingly, an extraordinarily high number of scientists return to this conference year after year. Participants are chosen from amongst the most promising and productive scientists, at all stages in their careers and from diverse disciplines. Their bond is a common interest in the topic of regulation of the normal and diseased heart with a focus on Ca2+ regulatory mechanisms. We have a good mix of fundamental science related to regulation of normal cardiac electrical and mechanical properties, cardiac myocyte cell signaling, and abnormalities in these processes that contribute to cardiac dysfunction. The increased use of genetically modified animals and the development of defined cardiovascular phenotypes has made the cardiovascular system tractable and thus of broad and expanding interest to the cell signaling field. This year's conference has a particular focus on signaling pathways and includes several new areas of intense research interest including mitochondrial Ca2+ regulation, redox regulation, new model systems, subcellular compartments and their real time imaging. Other sessions focus on arrhythmias, Ca2+ signaling in myocytes, and novel signaling pathways. Discussion leaders are charged with and are historically successful at promoting lively discussions and critical questioning. Indeed a key objective of this conference is to foster an inclusive, intense, lively and interactive atmosphere that highlights controversies and enlightens participants by providing a deeper understanding of unresolved issues. This is an exciting time in cardiovascular science because of the use of transgenic and knockout mouse models, genetic information and new technologies that allow us to explore the cellular and molecular basis of normal cardiac function. We are beginning to translate these new findings into a better understanding of disease mechanisms, diagnosis, prevention and treatment. We expect that the proposed presentations will be both exciting and timely, and to include late breaking science and young investigators in the oral session by recruiting speakers from poster contributions and recent publications. This is a conference that those who have regularly attended look forward to, and that new attendees and young scientists recognize as an invaluable learning and career experience.