2014 Cardiac Regulatory Mechanisms Gordon Research Conference & Gordon Research S

2014年心脏调节机制戈登研究会议

• 批准号: 8784793
• 负责人: MARK E ANDERSON
• 金额: $ 1万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-05 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8784793
• 关键词: Area; Arrhythmia; Cardiac; Cardiac Myocytes; Cardiomyopathies; Cardiovascular Diseases; Cardiovascular system; Clinical; Clinical Treatment; Data; Development; Diagnosis; Discipline; Disease; Ensure; Fostering; Functional disorder; Funding; Future; Genetic; Genetic Models; Genetically Modified Animals; Geography; Health; Heart; Human; Human Genetics; Image; Information Technology; Ion Channel; Ions; Knockout Mice; Learning; Mechanics; Medicine; Mentors; MicroRNAs; Mitochondria; Modeling; Molecular; Muscle Cells; Nature; Oral; Oxidation-Reduction; Participant; Phenotype; Physiology; Postdoctoral Fellow; Prevention; Process; Property; Publications; Published Comment; Recruitment Activity; Regulation; Research; Research Personnel; Role; Science; Scientist; Signal Pathway; Signal Transduction; Social Interaction; Source; Staging; Techniques; Time; Transgenic Mice; Translating; Translations; Work; abstracting; base; career; college; drug development; experience; field study; graduate student; induced pluripotent stem cell; innovation; interest; mouse model; new technology; next generation; novel; planetary Atmosphere; posters; public health relevance; symposium; tool

DESCRIPTION (provided by applicant): This application seeks partial funding for the Gordon research Conference (GRC) and the Gordon Research Seminar (GRS) on Cardiac Regulatory Mechanisms to be held at Colby Sawyer College (Colby-Sawyer, NH) on June 7-13, 2014. For over 25 years this conference has prided itself on bringing together new investigators and established leaders to present their latest unpublished findings and engage in meaningful scientific and social interactions. The informal nature of the GRC is unique in fostering discussions that span disciplines and geography and enables new personal and scientific connections to develop. Participants are chosen from amongst the most promising and productive scientists, at all stages in their careers and from diverse disciplines. The common interest is the topic of regulation of the normal and diseased heart with a focus on specific regulatory mechanisms that can be translated to novel therapies. We have a good mix of fundamental science related to regulation of normal cardiac electrical and mechanical properties, cardiac myocyte cell signaling, and abnormalities in these processes that contribute to cardiac dysfunction. The increased use of genetically modified animals and the development of defined cardiovascular phenotypes has made the cardiovascular system tractable and thus of broad and expanding interest to the cell signaling field. This year's conference has a particular focus on signaling pathways and includes several new areas of intense research interest including application of iPS cells to model human myocardial disease, mitochondrial Ca2+ regulation, redox regulation, subcellular compartments and their real time imaging. Other sessions focus on arrhythmias, Ca2+ signaling in myocytes, and emerging techniques to advance our field of study. Discussion leaders promote lively discussions and critical questioning. A key objective of this conference is to foster an inclusive, intensive, lively and interactive atmosphere that highlights controversies and enlightens participants by providing a deeper understanding of resolved issues. The inclusiveness of this conference in 2012 was enhanced by the GRS, a mechanism for highlighting work by graduate students and post-doctoral trainees. The GRS was well-received and will be held immediately prior to the GRC at Colby-Sawyer College. This is an exciting time in cardiovascular science because of the use of transgenic and knockout mouse models, genetic information and new technologies, including iPS cells that allow us to explore the cellular and molecular basis of normal cardiac function. We are beginning to translate these new findings into a better understanding of disease mechanisms, diagnosis, prevention and treatment. We expect that the proposed presentations will be both exciting and timely, and to include late breaking science and young investigators in the oral session by recruiting speakers from poster contributions and recent publications. This is a conference that those who have regularly attended look forward to, and that new attendees and young scientists recognize as an invaluable learning and career experience.

描述（由申请人提供）： 本申请旨在为戈登研究会议（GRC）和戈登研究研讨会（GRS）心脏调节机制将于2014年6月7日至13日在科尔比索耶学院（科尔比-索耶，NH）举行的部分资金。25年来，该会议一直致力于将新的研究人员和知名领导人聚集在一起，展示他们最新的未发表的发现，并进行有意义的科学和社会互动。GRC的非正式性质在促进跨越学科和地理的讨论方面是独一无二的，并使新的个人和科学联系得以发展。参与者是从最有前途和生产力的科学家中挑选出来的，他们处于职业生涯的各个阶段，来自不同的学科。共同的兴趣是调节正常和患病心脏的主题，重点是可以转化为新疗法的特定调节机制。我们拥有与正常心脏电和机械特性的调节、心肌细胞信号传导以及导致心脏功能障碍的这些过程异常相关的基础科学的良好组合。转基因动物的增加使用和定义的心血管表型的发展已经使得心血管系统易于处理，因此对细胞信号传导领域具有广泛和不断扩大的兴趣。今年的会议特别关注信号通路，包括几个新的研究领域，包括iPS细胞在模拟人类心肌疾病中的应用，线粒体Ca 2+调节，氧化还原调节，亚细胞区室及其真实的时间成像。其他会议集中在心律失常，Ca 2+信号在心肌细胞，和新兴技术，以推进我们的研究领域。讨论领导者促进活跃的讨论和批判性的提问。这次会议的一个主要目标是促进一个包容、 密集、活跃和互动的氛围，突出争议，通过提供对已解决问题的更深入理解来启发参与者。2012年的这次会议的包容性通过GRS得到了加强，GRS是一个突出研究生和博士后实习生工作的机制。GRS广受欢迎，将在Colby-Sawyer学院举行的GRC之前举行。这是心血管科学的一个激动人心的时刻，因为转基因和基因敲除小鼠模型，遗传信息和新技术的使用，包括iPS细胞，使我们能够探索正常心脏功能的细胞和分子基础。我们正开始将这些新发现转化为对疾病机制、诊断、预防和治疗的更好理解。我们希望拟议的演讲既令人兴奋又及时，并通过从海报贡献和最近的出版物中招募演讲者，在口头会议中包括最新突破的科学和年轻的研究人员。这是一个经常参加的会议，新的与会者和年轻的科学家认为这是一个宝贵的学习和职业经验。