ASTHMA CLINICAL RESEARCH NETWORK

哮喘临床研究网络

• 批准号: 8401835
• 负责人: Stephen I Wasserman
• 金额: $ 11.38万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-15 至 2011-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8401835
• 关键词: Adult; Area; Asthma; Biochemical; Biological; Breathing; California; Clinic; Clinical Research; Clinical Trials; Collaborations; Continuous Positive Airway Pressure; Controlled Clinical Trials; Critical Care; Double-Blind Method; Effectiveness; Enrollment; Environment; Equipment; Etanercept; Exercise-Induced Asthma; Faculty; Funding; Goals; Health; Hospitals; Human Resources; Hypersensitivity; Immune response; Immunology; Incidence; Inflammatory Response; Innovative Therapy; Institution; Investigation; Lung; Mediator of activation protein; Medicine; Molecular; Multi-Institutional Clinical Trial; National Heart, Lung, and Blood Institute; Nocturnal Asthma; Overweight; Patients; Performance; Pharmaceutical Preparations; Physiological; Placebo Control; Population; Pregnancy; Protocols documentation; Publishing; Pulmonology; Recruitment Activity; Research; Research Design; Research Personnel; Resources; Rheumatology; Sleep Apnea Syndromes; Steroids; Structure; United States National Institutes of Health; Universities; base; cytokine; design; dosage; experience; improved; innovation; member; novel; primary outcome; programs; respiratory; southeast Asian; tumor necrosis factor-alpha inhibitor

DESCRIPTION (provided by applicant): A consortium of investigators at the University of California, San Diego with extensive experience in, and a commitment to, clinical research collaborations in the area of asthma, are proposing two multi-center clinical trials for the NIH-sponsored Asthma Clinical Research Network. The UCSD consortium is led by Drs. Stephen Wasserman and Joe Ramsdell. Study 1 will be undertaken in stable steroid dependent asthmatic adults. It will examine the effect of etanercept, an inhibitor of TNF-alpha, in an 18-week, double-blind, placebo-controlled clinical trial in this population. The primary outcome to be evaluated will be the ability of this agent to permit significant reduction in inhaled steroid dosage without exacerbation. Study 2 will also employ a double-blind, placebo-controlled design. This trial will evaluate the ability of CPAP to improve nocturnal asthma, in a population of overweight, adult patients with moderate-to-severe asthma, who also suffer from sleep disordered breathing. Patients for these, and other Network trials, will be recruited from the Medicine, Pulmonary and Allergy clinics of UCSD, the San Diego VA, the San Diego US Naval Hospital, and Kaiser- Permanente. The available population is large, multi-racial and multi-ethnic, reflecting the San Diego environment. We are also proposing an educational program, under the direction of Dr. Andrew Ries, which will utilize the extensive resources available at UCSD.

描述（由申请人提供）：

项目成果

2007 San Diego wildfires and asthmatics.

2007 年圣地亚哥野火和哮喘病。

• DOI: 10.3109/02770903.2010.535885
• 发表时间: 2011
• 期刊: The Journal of asthma : official journal of the Association for the Care of Asthma
• 作者: Vora,Chirag;Renvall,MarianJ;Chao,Peter;Ferguson,Paul;Ramsdell,JoeW
• 通讯作者: Ramsdell,JoeW