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Development of recombinant Lecithin Cholesterol Acyltransferase as a therapeutic

Development of recombinant Lecithin Cholesterol Acyltransferase as a therapeutic
开发重组卵磷脂胆固醇酰基转移酶作为治疗剂
批准号：
8344887
负责人：
Alan Thomas Remaley
金额：
$68.86万
依托单位：
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8344887
关键词：
AnemiaAnimalsAtherosclerosisBiological MarkersCholesterolClinicalClinical TrialsCorneaDepositionDevelopmentDiseaseEnd stage renal failureEnzymesExcisionGeneral PopulationHalf-LifeHigh Density LipoproteinsHumanIn VitroKidney DiseasesLegal patentLicensingLifeLipoproteinsMetabolismMusOryctolagus cuniculusPeripheralPhosphatidylcholine-Sterol O-AcyltransferasePlasmaRecombinantsResidual stateSplenomegalySterol O-AcyltransferaseTherapeuticTherapeutic AgentsTissuesTransgenic AnimalsUnited States National Institutes of Healthbasecardiovascular risk factorclinical toxicologyenzyme replacement therapyfamilial cholesteryl ester deficiencyin vivolecithin cholesterol acyltransferase deficiencyparticlepre-clinicalpremature atherosclerosisprevent

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英文摘要
In the past year, we have completed a pre-clinical animal study in LCAT K/O mice showing the feasibility of using recombinant LCAT as a therapeutic agent (ref. 2) and have also filed a provisional patent application, with our outside collaborators, on the use of LCAT for modulating HDL levels (ref. 1). In addition, we have shown that low LCAT levels was a biomarker for cardiovascular risk in the general population (ref. 3). In conjunction with our outside collaborators, who have licensed the patent from the NIH, we have completed the pre-clinical toxicology studies and have recently filed an IND to start a clinical trial.
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Development Of New Assays For Lipoprotein Testing
  • 批准号：
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  • 项目类别：
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    $0.0万
  • 财政年份：
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  • 负责人：
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  • 依托单位：
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  • 项目类别：
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  • 财政年份：
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  • 负责人：
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  • 依托单位：
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  • 批准号：
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  • 项目类别：
  • 资助金额：
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  • 财政年份：
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