Role of Innate and Adaptive Immune Systems in Drug-Induced Liver Disease

去年，我们发现调节性T细胞浸润到氟烷治疗后的雌性Balb/cJ小鼠的肝脏中，并抑制氟烷治疗后体内形成的三氟乙酰化蛋白的体液和细胞免疫反应。 今年，我们报告说，新发现的骨髓来源的抑制细胞也浸润到雌性Balb/cJ小鼠氟烷治疗后的肝脏。这些细胞最近已经显示出在肿瘤、感染和自身免疫性疾病中抑制效应T细胞活性。 结论：这些发现表明，调节性T细胞和髓源性抑制细胞可能在防止药物蛋白加合物引起的肝损伤的适应性免疫系统介导的作用，这些调节细胞的活动的缺陷可能是DILD的易感因素。

Last year we found that regulatory T cells infiltrated into the liver of female Balb/cJ mice following halothane treatment and inhibited both humoral and cellular immune reactions against trifluoroacetylated proteins formed in vivo following halothane treatment. This year we report that newly discovered myeloid-derived suppressor cells also infiltrated into the liver of female Balb/cJ mice following halothane treatment. These cells have be shown recently to inhibit effector T cell activity in tumors, infections, and in autoimmune diseases. Conclusion: These findings suggest that both regulatory T cells and myeloid-derived suppressor cells might have a role in preventing drug-protein adducts from causing liver injury mediated by the adaptive immune system and that deficiencies in the activities of these regulatory cells might be susceptibility factors in DILD.