Role of Innate and Adaptive Immune Systems in Drug-Induced Liver Disease

先天性和适应性免疫系统在药物性肝病中的作用

• 批准号: 8558025
• 负责人: Lance R Pohl
• 金额: $ 69.53万
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8558025
• 关键词: Acids; Adjuvant; Animal Model; Animals; Antibodies; Anticonvulsants; Antigen-Presenting Cells; Categories; Cells; Clinical; Disulfiram; Drug toxicity; Endothelial Cells; Erythromycin; Ethanol; Female; Goals; Halothane; Hepatic; Hepatocyte; Human; Immune; Immune response; Immune system; Injury; Kupffer Cells; Liver; Mediating; Modeling; Mus; Myelogenous; Pharmaceutical Preparations; Play; Process; Proteins; Reaction; Regulatory T-Lymphocyte; Reporting; Role; Sulfonamides; Suppressor-Effector T-Lymphocytes; T-Lymphocyte; Testing; Toxic effect; adduct; animal model development; drug induced liver disease; immunopathology; prevent; troglitazone

We have previously found that regulatory T cells and myeloid-derived suppressor cells infiltrated into the liver of female mice following halothane treatment and appeared to have tolerogenic activity preventing halothane to cause an adaptive immune response against the liver. This year we report that several other potentially tolerogenic cells enter the liver after halothane treatment. Conclusion: These findings suggest that multiple tolerogenic cells play a role in preventing drugs from cause adaptive immune reactions against the liver. Blocking the activities of these cells may allow the development of animal models for testing the potential of new for causing adaptive immune toxicities against the liver.

我们先前已经发现，在氟烷治疗后，调节性T细胞和髓系来源的抑制细胞渗入雌性小鼠的肝脏，并似乎具有耐受活性，阻止氟烷引起针对肝脏的适应性免疫反应。 今年，我们报告了其他几个潜在的耐受细胞在氟烷治疗后进入肝脏。 结论：多个耐受细胞在防止药物引起针对肝脏的获得性免疫反应中起作用。阻断这些细胞的活动可能会允许开发动物模型，以测试新细胞对肝脏造成适应性免疫毒性的可能性。