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Role of Innate and Adaptive Immune Systems in Drug-Induced Liver Disease

Role of Innate and Adaptive Immune Systems in Drug-Induced Liver Disease
先天性和适应性免疫系统在药物性肝病中的作用
批准号：
8558025
负责人：
Lance R Pohl
金额：
$69.53万
依托单位：
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8558025
关键词：
AcidsAdjuvantAnimal ModelAnimalsAntibodiesAnticonvulsantsAntigen-Presenting CellsCategoriesCellsClinicalDisulfiramDrug toxicityEndothelial CellsErythromycinEthanolFemaleGoalsHalothaneHepaticHepatocyteHumanImmuneImmune responseImmune systemInjuryKupffer CellsLiverMediatingModelingMusMyelogenousPharmaceutical PreparationsPlayProcessProteinsReactionRegulatory T-LymphocyteReportingRoleSulfonamidesSuppressor-Effector T-LymphocytesT-LymphocyteTestingToxic effectadductanimal model developmentdrug induced liver diseaseimmunopathologypreventtroglitazone

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英文摘要
We have previously found that regulatory T cells and myeloid-derived suppressor cells infiltrated into the liver of female mice following halothane treatment and appeared to have tolerogenic activity preventing halothane to cause an adaptive immune response against the liver. This year we report that several other potentially tolerogenic cells enter the liver after halothane treatment. Conclusion: These findings suggest that multiple tolerogenic cells play a role in preventing drugs from cause adaptive immune reactions against the liver. Blocking the activities of these cells may allow the development of animal models for testing the potential of new for causing adaptive immune toxicities against the liver.
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Mechanisms Of Drug-induced Toxicities
Mechanisms of Drug-Induced Liver Disease
Mechanisms of Drug-Induced Liver Disease
Role of Innate and Adaptive Immune Systems in Drug-Induced Liver Disease
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